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| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (435 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (641 aa) |
| | exo1 | Exonuclease 1. (767 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1425 aa) |
| | slx4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1448 aa) |
| | ENSPNYP00000003798 | Uncharacterized protein. (117 aa) |
| | ENSPNYP00000003596 | Cell division cycle associated 7b. (288 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa) |
| | ENSPNYP00000003481 | Uncharacterized protein. (103 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1473 aa) |
| | kxd1 | KxDL motif containing 1. (184 aa) |
| | sirt7 | Sirtuin 7. (405 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (269 aa) |
| | tdrd3 | Tudor domain containing 3. (780 aa) |
| | LOC102207357 | Small ubiquitin-related modifier. (94 aa) |
| | LOC102207116 | Cyclin A2; Belongs to the cyclin family. (440 aa) |
| | brca1 | Uncharacterized protein. (1180 aa) |
| | ENSPNYP00000000972 | Uncharacterized protein. (127 aa) |
| | LOC102195724 | Zgc:110269. (323 aa) |
| | ENSPNYP00000000749 | Uncharacterized protein. (95 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (400 aa) |
| | ENSPNYP00000000985 | Uncharacterized protein. (142 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa) |
| | ENSPNYP00000031920 | Ig-like domain-containing protein. (308 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa) |
| | H4C6 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | ENSPNYP00000031615 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (87 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (467 aa) |
| | rfc1 | Replication factor C subunit 1. (1153 aa) |
| | rnf168 | Ring finger protein 168. (404 aa) |
| | ENSPNYP00000030315 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (140 aa) |
| | mdc1 | Uncharacterized protein. (1729 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (283 aa) |
| | ENSPNYP00000029649 | Histone H2B; Belongs to the histone H2B family. (282 aa) |
| | ENSPNYP00000029339 | Uncharacterized protein. (213 aa) |
| | gen1 | Chromo_2 domain-containing protein. (640 aa) |
| | xrcc2 | X-ray repair cross complementing 2. (301 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (722 aa) |
| | ENSPNYP00000027632 | SAE2 domain-containing protein. (75 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (456 aa) |
| | timeless | Timeless circadian clock. (1183 aa) |
| | rps27a | Ribosomal protein S27a. (188 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | LOC102198009 | RAD51 paralog C. (358 aa) |
| | ENSPNYP00000025918 | Polymerase (DNA directed) kappa. (409 aa) |
| | ENSPNYP00000025405 | Uncharacterized protein. (98 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (689 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa) |
| | LOC102212740 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | rhno1 | Si:ch73-352p4.5. (217 aa) |
| | LOC102196148 | Uncharacterized protein. (409 aa) |
| | LOC106456278 | Ubiquitin-like domain-containing protein. (122 aa) |
| | ENSPNYP00000023182 | PWWP domain-containing protein. (156 aa) |
| | ENSPNYP00000023158 | Nuclear receptor binding SET domain protein 2. (465 aa) |
| | ube2i | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (509 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (507 aa) |
| | ENSPNYP00000022489 | Uncharacterized protein. (113 aa) |
| | rad51ap1 | RAD51 associated protein 1. (312 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2015 aa) |
| | uba52 | Ubiquitin-like domain-containing protein. (128 aa) |
| | LOC102215177 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1036 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (443 aa) |
| | ENSPNYP00000021180 | BRCA1/BRCA2-containing complex, subunit 3. (278 aa) |
| | LOC102212432 | Small ubiquitin-related modifier. (96 aa) |
| | LOC102201896 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa) |
| | LOC102199873 | Histone H2B; Belongs to the histone H2B family. (114 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | LOC102203776 | Small ubiquitin-related modifier. (94 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (158 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (935 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa) |
| | ENSPNYP00000019133 | RAP80_UIM domain-containing protein. (609 aa) |
| | LOC102204862 | MUS81 structure-specific endonuclease subunit. (500 aa) |
| | rpa2 | Replication protein A2. (293 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (326 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | LOC102214342 | Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | ccna1 | Cyclin A1; Belongs to the cyclin family. (389 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa) |
| | EME2 | ERCC4 domain-containing protein. (443 aa) |
| | rad51d | RAD51 paralog D. (333 aa) |
| | lig3 | DNA ligase. (1012 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | ENSPNYP00000015524 | Uncharacterized protein. (1445 aa) |
| | atm | Non-specific serine/threonine protein kinase. (3051 aa) |
| | chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (215 aa) |
| | LOC102203240 | BLM RecQ like helicase. (1339 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (679 aa) |
| | abraxas1 | Abraxas 1, BRCA1 A complex subunit. (346 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (635 aa) |
| | rnf169 | Ring finger protein 169. (585 aa) |
| | rcbtb2 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (999 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (276 aa) |
| | LOC102213521 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (527 aa) |
| | ENSPNYP00000011819 | RecQ helicase-like 4. (765 aa) |
| | pold1 | DNA polymerase. (1105 aa) |
| | rmi2 | RecQ mediated genome instability 2. (146 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (342 aa) |
| | cdca7 | Cell division cycle associated 7a. (352 aa) |
| | rad1 | RAD1 homolog (S. pombe). (279 aa) |
| | pold4 | Si:dkey-28b4.7. (107 aa) |
| | ENSPNYP00000010025 | Uncharacterized protein. (124 aa) |
| | abl1 | Tyrosine-protein kinase. (1112 aa) |
| | polh | Polymerase (DNA directed), eta. (722 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2444 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (532 aa) |
| | ENSPNYP00000008693 | RAD17 checkpoint clamp loader component. (445 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (342 aa) |
| | sirt6 | Sirtuin 6. (351 aa) |
| | ENSPNYP00000008349 | Reverse transcriptase domain-containing protein. (163 aa) |
| | ENSPNYP00000007911 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (300 aa) |
| | nbn | Nibrin. (776 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (1926 aa) |
| | ENSPNYP00000007155 | Histone H2A; Belongs to the histone H2A family. (141 aa) |
| | ENSPNYP00000006833 | Uncharacterized protein. (255 aa) |
| | ENSPNYP00000006710 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | ENSPNYP00000006654 | Reverse transcriptase domain-containing protein. (471 aa) |
| | LOC102208891 | ERCC4 domain-containing protein. (398 aa) |
| | LOC102214393 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | ankrd11 | Ankyrin repeat domain 11. (2845 aa) |
| | ENSPNYP00000006437 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (97 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (356 aa) |
| | LOC102204281 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (259 aa) |
| | ENSPNYP00000005212 | Ubiquitin-like domain-containing protein. (114 aa) |
