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ENSPNYP00000029233 ENSPNYP00000029233 csnk2a2 csnk2a2 ENSPNYP00000029805 ENSPNYP00000029805 taf5l taf5l top3a top3a RPA1 RPA1 tbpl1 tbpl1 tdrd3 tdrd3 prkag1 prkag1 ENSPNYP00000002256 ENSPNYP00000002256 kxd1 kxd1 LOC102209265 LOC102209265 taf3 taf3 ENSPNYP00000003481 ENSPNYP00000003481 ENSPNYP00000003596 ENSPNYP00000003596 PRKAA1 PRKAA1 topbp1 topbp1 LOC102206681 LOC102206681 exo1 exo1 LOC102208528 LOC102208528 ENSPNYP00000004931 ENSPNYP00000004931 ENSPNYP00000004959 ENSPNYP00000004959 taf5 taf5 ENSPNYP00000005212 ENSPNYP00000005212 LOC102214117 LOC102214117 rfc2 rfc2 ankrd11 ankrd11 ENSPNYP00000006833 ENSPNYP00000006833 LOC102214488 LOC102214488 ankrd12 ankrd12 nbn nbn cdk5r2 cdk5r2 ENSPNYP00000007911 ENSPNYP00000007911 pin1 pin1 ENSPNYP00000008125 ENSPNYP00000008125 nuak1 nuak1 noc2l noc2l LOC102202192 LOC102202192 ENSPNYP00000008693 ENSPNYP00000008693 ENSPNYP00000008816 ENSPNYP00000008816 ENSPNYP00000009015 ENSPNYP00000009015 atr atr stk11 stk11 LOC102215507 LOC102215507 tp53rk tp53rk PRKAB2 PRKAB2 ENSPNYP00000010025 ENSPNYP00000010025 rad1 rad1 LOC102212857 LOC102212857 cdca7 cdca7 LOC102195040 LOC102195040 rfc5 rfc5 LOC102206169 LOC102206169 rmi2 rmi2 LOC102196795 LOC102196795 prkaa2 prkaa2 LOC102209088 LOC102209088 ENSPNYP00000011819 ENSPNYP00000011819 prkab1 prkab1 taf13 taf13 hus1 hus1 taf10 taf10 LOC102198209 LOC102198209 exd2 exd2 rmi1 rmi1 rpa3 rpa3 LOC102203240 LOC102203240 chek1 chek1 atm atm ENSPNYP00000015023 ENSPNYP00000015023 ENSPNYP00000015251 ENSPNYP00000015251 dyrk2 dyrk2 LOC102211115 LOC102211115 taf7l taf7l rfc4 rfc4 LOC102195254 LOC102195254 ccna1 ccna1 LOC102205547 LOC102205547 LOC102207154 LOC102207154 rfc3 rfc3 rpa2 rpa2 ENSPNYP00000018745 ENSPNYP00000018745 ENSPNYP00000018758 ENSPNYP00000018758 ENSPNYP00000018768 ENSPNYP00000018768 LOC102215705 LOC102215705 ENSPNYP00000019294 ENSPNYP00000019294 taf2 taf2 LOC102209720 LOC102209720 rad50 rad50 tp53inp1 tp53inp1 cdk5 cdk5 dna2 dna2 LOC102215177 LOC102215177 LOC102207774 LOC102207774 uba52 uba52 tbp tbp mapkapk5 mapkapk5 ENSPNYP00000022489 ENSPNYP00000022489 ssrp1 ssrp1 kat5 kat5 mdm2 mdm2 LOC106456278 LOC106456278 mdm4 mdm4 taf6 taf6 csnk2b csnk2b rhno1 rhno1 dyrk3 dyrk3 mre11 mre11 hipk3 hipk3 taf11 taf11 taf1 taf1 LOC102215422 LOC102215422 LOC102195157 LOC102195157 ENSPNYP00000025971 ENSPNYP00000025971 cdk2 cdk2 rps27a rps27a LOC102214989 LOC102214989 ENSPNYP00000026966 ENSPNYP00000026966 ENSPNYP00000027058 ENSPNYP00000027058 ENSPNYP00000027375 ENSPNYP00000027375 meiob meiob ENSPNYP00000027632 ENSPNYP00000027632 supt16h supt16h ENSPNYP00000027800 ENSPNYP00000027800 hipk2 hipk2 slf1 slf1 LOC102216155 LOC102216155 TAF4 TAF4 ENSPNYP00000029225 ENSPNYP00000029225 ENSPNYP00000000487 ENSPNYP00000000487 tpx2 tpx2 brca1 brca1 LOC102207116 LOC102207116 cdk5r1 cdk5r1 tp53inp2 tp53inp2 LOC102205661 LOC102205661
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPNYP00000029233Uncharacterized protein. (224 aa)
csnk2a2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (350 aa)
ENSPNYP00000029805Uncharacterized protein. (102 aa)
taf5lTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (600 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
tbpl1TBP-like 1. (187 aa)
tdrd3Tudor domain containing 3. (780 aa)
prkag1Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (326 aa)
ENSPNYP00000002256TAF4 domain-containing protein. (280 aa)
kxd1KxDL motif containing 1. (184 aa)
LOC102209265Protein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (268 aa)
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto. (940 aa)
ENSPNYP00000003481Uncharacterized protein. (103 aa)
ENSPNYP00000003596Cell division cycle associated 7b. (288 aa)
PRKAA1Non-specific serine/threonine protein kinase. (506 aa)
topbp1DNA topoisomerase II binding protein 1. (1425 aa)
LOC102206681Uncharacterized protein. (336 aa)
exo1Exonuclease 1. (767 aa)
LOC102208528Cyclin-dependent kinase 5 activator. (330 aa)
ENSPNYP00000004931Protein kinase domain-containing protein. (108 aa)
ENSPNYP00000004959Zgc:171775. (247 aa)
taf5TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (750 aa)
ENSPNYP00000005212Ubiquitin-like domain-containing protein. (114 aa)
LOC102214117TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (247 aa)
rfc2Replication factor C (activator 1) 2. (356 aa)
ankrd11Ankyrin repeat domain 11. (2845 aa)
ENSPNYP00000006833Uncharacterized protein. (255 aa)
LOC102214488TAFH domain-containing protein. (888 aa)
ankrd12Ankyrin repeat domain 12. (1926 aa)
nbnNibrin. (776 aa)
cdk5r2Cyclin-dependent kinase 5, regulatory subunit 2b (p39). (295 aa)
ENSPNYP00000007911Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (300 aa)
pin1Peptidyl-prolyl cis-trans isomerase. (156 aa)
ENSPNYP00000008125Protein kinase domain-containing protein. (558 aa)
nuak1NUAK family, SNF1-like kinase, 1b. (656 aa)
noc2lNOC2-like nucleolar associated transcriptional repressor. (749 aa)
LOC102202192Si:ch211-160o17.4. (1101 aa)
ENSPNYP00000008693RAD17 checkpoint clamp loader component. (445 aa)
ENSPNYP00000008816Tumor protein p53. (357 aa)
ENSPNYP00000009015Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (209 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2444 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (396 aa)
LOC102215507Casein kinase 2, alpha 4 polypeptide; Belongs to the protein kinase superfamily. (393 aa)
tp53rkTP53 regulating kinase. (236 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (268 aa)
ENSPNYP00000010025Uncharacterized protein. (124 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
LOC102212857Aurora kinase B; Belongs to the protein kinase superfamily. (322 aa)
cdca7Cell division cycle associated 7a. (352 aa)
LOC102195040NUAK family, SNF1-like kinase, 2. (626 aa)
rfc5Replication factor C (activator 1) 5. (342 aa)
LOC102206169Mitogen-activated protein kinase. (361 aa)
rmi2RecQ mediated genome instability 2. (146 aa)
LOC102196795TATA box binding protein like 2. (320 aa)
prkaa2Non-specific serine/threonine protein kinase. (557 aa)
LOC102209088Protein kinase domain-containing protein. (1145 aa)
ENSPNYP00000011819RecQ helicase-like 4. (765 aa)
prkab1Protein kinase, AMP-activated, beta 1 non-catalytic subunit, a. (269 aa)
taf13TATA-box binding protein associated factor 13. (124 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (276 aa)
taf10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
LOC102198209TAFH domain-containing protein. (931 aa)
exd2Exonuclease 3'-5' domain containing 2. (635 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (679 aa)
rpa3Replication protein A3. (122 aa)
LOC102203240BLM RecQ like helicase. (1339 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (215 aa)
atmNon-specific serine/threonine protein kinase. (3051 aa)
ENSPNYP00000015023Uncharacterized protein. (177 aa)
ENSPNYP00000015251Protein kinase domain-containing protein. (168 aa)
dyrk2Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2. (588 aa)
LOC102211115Mitogen-activated protein kinase. (346 aa)
taf7lTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (362 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
LOC102195254Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (545 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (389 aa)
LOC102205547Zgc:86598; Belongs to the protein kinase superfamily. (392 aa)
LOC102207154Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rpa2Replication protein A2. (293 aa)
ENSPNYP00000018745Si:ch211-117c9.1. (121 aa)
ENSPNYP00000018758Uncharacterized protein. (211 aa)
ENSPNYP00000018768Protein kinase domain-containing protein. (146 aa)
LOC102215705Checkpoint kinase 2. (476 aa)
ENSPNYP00000019294TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (163 aa)
taf2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (1213 aa)
LOC102209720Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (292 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
tp53inp1Tumor protein p53 inducible nuclear protein 1. (296 aa)
cdk5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
dna2DNA replication helicase/nuclease 2. (1036 aa)
LOC102215177Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
LOC102207774Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (284 aa)
uba52Ubiquitin-like domain-containing protein. (128 aa)
tbpTATA box binding protein. (287 aa)
mapkapk5MAPK activated protein kinase 5. (471 aa)
ENSPNYP00000022489Uncharacterized protein. (113 aa)
ssrp1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (626 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
mdm2MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (457 aa)
LOC106456278Ubiquitin-like domain-containing protein. (122 aa)
mdm4MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (495 aa)
taf6TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (638 aa)
csnk2bCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
rhno1Si:ch73-352p4.5. (217 aa)
dyrk3Dual specificity tyrosine phosphorylation regulated kinase 3. (604 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (689 aa)
hipk3Homeodomain interacting protein kinase 3b. (1311 aa)
taf11TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (204 aa)
taf1Transcription initiation factor TFIID subunit. (1830 aa)
LOC102215422Cyclin-dependent kinase 5 activator. (335 aa)
LOC102195157TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor. (854 aa)
ENSPNYP00000025971Protein kinase domain-containing protein. (232 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
rps27aRibosomal protein S27a. (188 aa)
LOC102214989Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4. (624 aa)
ENSPNYP00000026966Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (349 aa)
ENSPNYP00000027058Uncharacterized protein. (363 aa)
ENSPNYP00000027375Protein kinase domain-containing protein. (211 aa)
meiobMethionine sulfoxide reductase B1b. (456 aa)
ENSPNYP00000027632SAE2 domain-containing protein. (75 aa)
supt16hSPT16 homolog, facilitates chromatin remodeling subunit. (716 aa)
ENSPNYP00000027800FACT-Spt16_Nlob domain-containing protein. (73 aa)
hipk2Homeodomain interacting protein kinase 2. (1222 aa)
slf1SMC5-SMC6 complex localization factor 1. (722 aa)
LOC102216155Homeodomain interacting protein kinase 1a. (1095 aa)
TAF4TATA-box binding protein associated factor 4. (842 aa)
ENSPNYP00000029225CBS domain-containing protein. (257 aa)
ENSPNYP00000000487Protein kinase domain-containing protein. (191 aa)
tpx2TPX2 microtubule nucleation factor. (563 aa)
brca1Uncharacterized protein. (1180 aa)
LOC102207116Cyclin A2; Belongs to the cyclin family. (440 aa)
cdk5r1Cyclin-dependent kinase 5 activator. (302 aa)
tp53inp2Uncharacterized protein. (181 aa)
LOC102205661Casein kinase 2, alpha prime polypeptide a; Belongs to the protein kinase superfamily. (350 aa)
Your Current Organism:
Pundamilia nyererei
NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei
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