STRINGSTRING
anapc4 anapc4 FZR1 FZR1 LOC102205309 LOC102205309 rpa3 rpa3 mcm7 mcm7 anapc10 anapc10 anapc7 anapc7 bicra bicra psmd8 psmd8 cdc26 cdc26 cdt1 cdt1 LOC102199700 LOC102199700 cdc45 cdc45 LOC102205886 LOC102205886 psma3 psma3 kpna5 kpna5 anapc2 anapc2 ENSPNYP00000013003 ENSPNYP00000013003 ENSPNYP00000013015 ENSPNYP00000013015 H2AZ1 H2AZ1 LOC102203937 LOC102203937 anapc1 anapc1 psma4 psma4 psmc5 psmc5 H3-3B H3-3B psmb3 psmb3 ENSPNYP00000007971 ENSPNYP00000007971 ENSPNYP00000007911 ENSPNYP00000007911 psmb4 psmb4 psmb7 psmb7 LOC102207966 LOC102207966 orc1 orc1 ENSPNYP00000007155 ENSPNYP00000007155 ENSPNYP00000006710 ENSPNYP00000006710 LOC102214393 LOC102214393 ENSPNYP00000006437 ENSPNYP00000006437 ENSPNYP00000006191 ENSPNYP00000006191 bicral bicral kpna6 kpna6 kpna1 kpna1 psmd5 psmd5 psmd2 psmd2 psma1 psma1 cdc16 cdc16 gmnn gmnn ENSPNYP00000000172 ENSPNYP00000000172 pola1 pola1 ENSPNYP00000000493 ENSPNYP00000000493 LOC102210136 LOC102210136 psmd14 psmd14 LOC102203116 LOC102203116 LOC102203678 LOC102203678 LOC102209997 LOC102209997 psmd6 psmd6 LOC102204261 LOC102204261 ENSPNYP00000001750 ENSPNYP00000001750 LOC102205503 LOC102205503 psmd13 psmd13 psme3 psme3 anapc5 anapc5 ENSPNYP00000002260 ENSPNYP00000002260 ube2s ube2s cdc7 cdc7 kxd1 kxd1 ENSPNYP00000003003 ENSPNYP00000003003 psmb2 psmb2 pole3 pole3 anapc11 anapc11 ENSPNYP00000004124 ENSPNYP00000004124 ENSPNYP00000004145 ENSPNYP00000004145 psmd7 psmd7 ENSPNYP00000005212 ENSPNYP00000005212 LOC102205179 LOC102205179 meiob meiob orc3 orc3 rps27a rps27a cdk2 cdk2 prim2 prim2 LOC102196183 LOC102196183 PSMD11 PSMD11 psmc2 psmc2 psmd12 psmd12 psmd3 psmd3 psma5 psma5 kpnb1 kpnb1 LOC106456278 LOC106456278 ENSPNYP00000023221 ENSPNYP00000023221 orc5 orc5 pole2 pole2 orc2 orc2 pole pole psmb1 psmb1 psmc3 psmc3 mcm6 mcm6 uba52 uba52 LOC102215177 LOC102215177 cdc27 cdc27 pola2 pola2 mcm10 mcm10 LOC102199873 LOC102199873 LOC102216045 LOC102216045 LOC102197382 LOC102197382 cdc23 cdc23 ENSPNYP00000020122 ENSPNYP00000020122 mcm4 mcm4 psmc6 psmc6 ube2c ube2c tm7sf3 tm7sf3 rpa2 rpa2 psmd9 psmd9 psma2 psma2 anapc15 anapc15 psme1 psme1 LOC102210761 LOC102210761 LOC102210455 LOC102210455 LOC102200259 LOC102200259 LOC102199716 LOC102199716 LOC102199990 LOC102199990 psmb8 psmb8 mcm8 mcm8 RPA1 RPA1 ENSPNYP00000031825 ENSPNYP00000031825 ENSPNYP00000031634 ENSPNYP00000031634 H4C6 H4C6 ENSPNYP00000031615 ENSPNYP00000031615 ENSPNYP00000031533 ENSPNYP00000031533 LOC102207232 LOC102207232 cdc6 cdc6 ENSPNYP00000030337 ENSPNYP00000030337 ENSPNYP00000030315 ENSPNYP00000030315 psma6 psma6 mcm2 mcm2 ENSPNYP00000029698 ENSPNYP00000029698 LOC102203686 LOC102203686 ENSPNYP00000029649 ENSPNYP00000029649 orc4 orc4 psmc4 psmc4 psme2 psme2 psmc1 psmc1 LOC102199978 LOC102199978 ENSPNYP00000028993 ENSPNYP00000028993 pole4 pole4 fam89a fam89a ENSPNYP00000028654 ENSPNYP00000028654 psmd1 psmd1 anapc16 anapc16 mcm3 mcm3 prim1 prim1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (780 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (492 aa)
LOC102205309Proteasome subunit beta. (278 aa)
rpa3Replication protein A3. (122 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (723 aa)
anapc10Anaphase promoting complex subunit 10. (136 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
bicraBRD4 interacting chromatin remodeling complex associated protein. (1776 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
cdc26Cell division cycle 26 homolog. (97 aa)
cdt1Chromatin licensing and DNA replication factor 1. (486 aa)
LOC102199700WD_REPEATS_REGION domain-containing protein. (489 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (522 aa)
LOC102205886Histone H2A; Belongs to the histone H2A family. (128 aa)
psma3Proteasome subunit alpha type. (255 aa)
kpna5Importin subunit alpha; Belongs to the importin alpha family. (536 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (752 aa)
ENSPNYP00000013003Histone domain-containing protein. (134 aa)
ENSPNYP00000013015Histone H2A; Belongs to the histone H2A family. (126 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (131 aa)
LOC102203937Proteasome 26S subunit, non-ATPase 4a. (377 aa)
anapc1Anaphase promoting complex subunit 1. (1872 aa)
psma4Proteasome subunit alpha type. (261 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (407 aa)
H3-3BH3 histone, family 3B. (136 aa)
psmb3Proteasome subunit beta. (205 aa)
ENSPNYP00000007971DBF4-type domain-containing protein. (430 aa)
ENSPNYP00000007911Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (300 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
psmb7Proteasome subunit beta. (286 aa)
LOC102207966Proteasome 26S subunit, non-ATPase 4b. (375 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (783 aa)
ENSPNYP00000007155Histone H2A; Belongs to the histone H2A family. (141 aa)
ENSPNYP00000006710Histone H2B; Belongs to the histone H2B family. (116 aa)
LOC102214393Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSPNYP00000006437Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (97 aa)
ENSPNYP00000006191Histone H2A; Belongs to the histone H2A family. (145 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (520 aa)
kpna6Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
kpna1Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (906 aa)
psma1Proteasome subunit alpha type. (263 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (619 aa)
gmnnGeminin DNA replication inhibitor. (208 aa)
ENSPNYP00000000172ANK_REP_REGION domain-containing protein. (102 aa)
pola1DNA polymerase. (1364 aa)
ENSPNYP00000000493Uncharacterized protein. (80 aa)
LOC102210136Histone H3; Belongs to the histone H3 family. (99 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
LOC102203116UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
LOC102203678Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (250 aa)
LOC102209997Proteasome 26S subunit, non-ATPase 11b. (422 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (392 aa)
LOC102204261Histone H3; Belongs to the histone H3 family. (136 aa)
ENSPNYP00000001750Uncharacterized protein. (53 aa)
LOC102205503Proteasome subunit alpha type. (248 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (378 aa)
psme3Proteasome activator subunit 3. (256 aa)
anapc5Anaphase promoting complex subunit 5. (721 aa)
ENSPNYP00000002260Histone H2A; Belongs to the histone H2A family. (140 aa)
ube2sUbiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (233 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (510 aa)
kxd1KxDL motif containing 1. (184 aa)
ENSPNYP00000003003Uncharacterized protein; Belongs to the histone H2A family. (141 aa)
psmb2Proteasome subunit beta. (199 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
ENSPNYP00000004124Proteasome inhibitor subunit 1. (236 aa)
ENSPNYP00000004145Histone H3; Belongs to the histone H3 family. (95 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (332 aa)
ENSPNYP00000005212Ubiquitin-like domain-containing protein. (114 aa)
LOC102205179Fizzy/cell division cycle 20 related 1b. (487 aa)
meiobMethionine sulfoxide reductase B1b. (456 aa)
orc3Origin recognition complex, subunit 3. (705 aa)
rps27aRibosomal protein S27a. (188 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
LOC102196183Proteasome subunit beta. (281 aa)
PSMD11PCI domain-containing protein. (422 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (562 aa)
psma5Proteasome subunit alpha type. (241 aa)
kpnb1Karyopherin (importin) beta 1. (916 aa)
LOC106456278Ubiquitin-like domain-containing protein. (122 aa)
ENSPNYP00000023221Histone H2A; Belongs to the histone H2A family. (138 aa)
orc5Origin recognition complex, subunit 5. (404 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (509 aa)
orc2Origin recognition complex, subunit 2. (429 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2015 aa)
psmb1Proteasome subunit beta. (237 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
mcm6DNA helicase; Belongs to the MCM family. (825 aa)
uba52Ubiquitin-like domain-containing protein. (128 aa)
LOC102215177Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
cdc27Cell division cycle 27. (833 aa)
pola2Polymerase (DNA directed), alpha 2. (565 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (806 aa)
LOC102199873Histone H2B; Belongs to the histone H2B family. (114 aa)
LOC102216045Histone H3.3. (136 aa)
LOC102197382Proteasome subunit beta 6. (221 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (575 aa)
ENSPNYP00000020122Uncharacterized protein. (133 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
tm7sf3Transmembrane 7 superfamily member 3. (554 aa)
rpa2Replication protein A2. (293 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
psma2Proteasome subunit alpha type. (234 aa)
anapc15Anaphase promoting complex subunit 15. (122 aa)
psme1Proteasome activator subunit 1. (301 aa)
LOC102210761Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
LOC102210455UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
LOC102200259Proteasome subunit beta. (216 aa)
LOC102199716Proteasome subunit beta 12. (217 aa)
LOC102199990Proteasome subunit beta. (275 aa)
psmb8Proteasome subunit beta. (279 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (838 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
ENSPNYP00000031825Proteasome 26S subunit, non-ATPase 10. (138 aa)
ENSPNYP00000031634Histone H2A; Belongs to the histone H2A family. (150 aa)
H4C6Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSPNYP00000031615Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (87 aa)
ENSPNYP00000031533Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC102207232Histone H3.3. (136 aa)
cdc6Cell division cycle 6 homolog (S. cerevisiae). (434 aa)
ENSPNYP00000030337Histone H3; Belongs to the histone H3 family. (103 aa)
ENSPNYP00000030315Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (140 aa)
psma6Proteasome subunit alpha type. (246 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
ENSPNYP00000029698Histone H2A; Belongs to the histone H2A family. (127 aa)
LOC102203686Histone H3; Belongs to the histone H3 family. (121 aa)
ENSPNYP00000029649Histone H2B; Belongs to the histone H2B family. (282 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
psme2Proteasome activator subunit 2. (245 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
LOC102199978Proteasome subunit alpha type. (246 aa)
ENSPNYP00000028993SCY domain-containing protein. (124 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
fam89aFamily with sequence similarity 89 member A. (180 aa)
ENSPNYP00000028654Uncharacterized protein. (295 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (951 aa)
anapc16Anaphase promoting complex subunit 16. (108 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa)
Your Current Organism:
Pundamilia nyererei
NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei
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