STRINGSTRING
LOC102203116 LOC102203116 LOC102195724 LOC102195724 psmd14 psmd14 anapc7 anapc7 anapc10 anapc10 pold4 pold4 mcm7 mcm7 LOC102205309 LOC102205309 FZR1 FZR1 mcm8 mcm8 pole pole psmb1 psmb1 psmc3 psmc3 mcm6 mcm6 uba52 uba52 gins4 gins4 bicra bicra psmd8 psmd8 rfc5 rfc5 cdc26 cdc26 cdt1 cdt1 LOC102199700 LOC102199700 pold1 pold1 pcna pcna psma3 psma3 gins2 gins2 LOC102215177 LOC102215177 dna2 dna2 pold3 pold3 cdc27 cdc27 pola2 pola2 LOC102201896 LOC102201896 LOC102195846 LOC102195846 LOC102197382 LOC102197382 anapc2 anapc2 LOC102203937 LOC102203937 rcbtb2 rcbtb2 anapc1 anapc1 psma4 psma4 psmc5 psmc5 rpa3 rpa3 psma1 psma1 cdc16 cdc16 gmnn gmnn anapc4 anapc4 psmb8 psmb8 LOC102199990 LOC102199990 LOC102199716 LOC102199716 LOC102200259 LOC102200259 rfc4 rfc4 LOC102212057 LOC102212057 cdc23 cdc23 ENSPNYP00000020122 ENSPNYP00000020122 mcm4 mcm4 psmc6 psmc6 ube2c ube2c tm7sf3 tm7sf3 rpa2 rpa2 ENSPNYP00000018622 ENSPNYP00000018622 LOC102203678 LOC102203678 ENSPNYP00000000172 ENSPNYP00000000172 pola1 pola1 ENSPNYP00000000493 ENSPNYP00000000493 psmb3 psmb3 ENSPNYP00000007911 ENSPNYP00000007911 psmb4 psmb4 psmb7 psmb7 LOC102207966 LOC102207966 orc1 orc1 rfc2 rfc2 bicral bicral orc2 orc2 pole2 pole2 orc5 orc5 LOC106456278 LOC106456278 psma5 psma5 psmd3 psmd3 pold2 pold2 psmd12 psmd12 psmc2 psmc2 psme4 psme4 PSMD11 PSMD11 ENSPNYP00000025540 ENSPNYP00000025540 LOC102196183 LOC102196183 gins1 gins1 prim2 prim2 cdk2 cdk2 rps27a rps27a ccne1 ccne1 orc3 orc3 gins3 gins3 meiob meiob LOC102205179 LOC102205179 prim1 prim1 mcm3 mcm3 anapc16 anapc16 psmd1 psmd1 psmd5 psmd5 ENSPNYP00000005212 ENSPNYP00000005212 fen1 fen1 psmd7 psmd7 ENSPNYP00000004124 ENSPNYP00000004124 anapc11 anapc11 LOC102214802 LOC102214802 pole3 pole3 psmb2 psmb2 psmd9 psmd9 RCBTB1 RCBTB1 rfc3 rfc3 psma2 psma2 ENSPNYP00000017722 ENSPNYP00000017722 ccna1 ccna1 anapc15 anapc15 psma8 psma8 psme1 psme1 skp1 skp1 LOC102210761 LOC102210761 LOC102210455 LOC102210455 atad5 atad5 kxd1 kxd1 lig1 lig1 ube2s ube2s anapc5 anapc5 psme3 psme3 psmd13 psmd13 LOC102205503 LOC102205503 psmd6 psmd6 LOC102209997 LOC102209997 LOC102207116 LOC102207116 ENSPNYP00000028654 ENSPNYP00000028654 fam89a fam89a pole4 pole4 ENSPNYP00000028993 ENSPNYP00000028993 LOC102199978 LOC102199978 psmc1 psmc1 psme2 psme2 psmc4 psmc4 orc4 orc4 mcm2 mcm2 psma6 psma6 rfc1 rfc1 cdc6 cdc6 skp2 skp2 ENSPNYP00000031825 ENSPNYP00000031825 rbx1 rbx1 RPA1 RPA1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102203116UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
LOC102195724Zgc:110269. (323 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
anapc10Anaphase promoting complex subunit 10. (136 aa)
pold4Si:dkey-28b4.7. (107 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (723 aa)
LOC102205309Proteasome subunit beta. (278 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (492 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (838 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2015 aa)
psmb1Proteasome subunit beta. (237 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
mcm6DNA helicase; Belongs to the MCM family. (825 aa)
uba52Ubiquitin-like domain-containing protein. (128 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
bicraBRD4 interacting chromatin remodeling complex associated protein. (1776 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
rfc5Replication factor C (activator 1) 5. (342 aa)
cdc26Cell division cycle 26 homolog. (97 aa)
cdt1Chromatin licensing and DNA replication factor 1. (486 aa)
LOC102199700WD_REPEATS_REGION domain-containing protein. (489 aa)
pold1DNA polymerase. (1105 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
psma3Proteasome subunit alpha type. (255 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (175 aa)
LOC102215177Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
dna2DNA replication helicase/nuclease 2. (1036 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (443 aa)
cdc27Cell division cycle 27. (833 aa)
pola2Polymerase (DNA directed), alpha 2. (565 aa)
LOC102201896Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
LOC102195846Cyclin E2; Belongs to the cyclin family. (380 aa)
LOC102197382Proteasome subunit beta 6. (221 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (752 aa)
LOC102203937Proteasome 26S subunit, non-ATPase 4a. (377 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
anapc1Anaphase promoting complex subunit 1. (1872 aa)
psma4Proteasome subunit alpha type. (261 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (407 aa)
rpa3Replication protein A3. (122 aa)
psma1Proteasome subunit alpha type. (263 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (619 aa)
gmnnGeminin DNA replication inhibitor. (208 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (780 aa)
psmb8Proteasome subunit beta. (279 aa)
LOC102199990Proteasome subunit beta. (275 aa)
LOC102199716Proteasome subunit beta 12. (217 aa)
LOC102200259Proteasome subunit beta. (216 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
LOC102212057Proteasome subunit beta11b. (362 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (575 aa)
ENSPNYP00000020122Uncharacterized protein. (133 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
tm7sf3Transmembrane 7 superfamily member 3. (554 aa)
rpa2Replication protein A2. (293 aa)
ENSPNYP00000018622Uncharacterized protein. (967 aa)
LOC102203678Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (250 aa)
ENSPNYP00000000172ANK_REP_REGION domain-containing protein. (102 aa)
pola1DNA polymerase. (1364 aa)
ENSPNYP00000000493Uncharacterized protein. (80 aa)
psmb3Proteasome subunit beta. (205 aa)
ENSPNYP00000007911Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (300 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
psmb7Proteasome subunit beta. (286 aa)
LOC102207966Proteasome 26S subunit, non-ATPase 4b. (375 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (783 aa)
rfc2Replication factor C (activator 1) 2. (356 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (520 aa)
orc2Origin recognition complex, subunit 2. (429 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (509 aa)
orc5Origin recognition complex, subunit 5. (404 aa)
LOC106456278Ubiquitin-like domain-containing protein. (122 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (562 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psme4Proteasome activator subunit 4a. (1847 aa)
PSMD11PCI domain-containing protein. (422 aa)
ENSPNYP00000025540Proteasome subunit beta. (288 aa)
LOC102196183Proteasome subunit beta. (281 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (196 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
rps27aRibosomal protein S27a. (188 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (432 aa)
orc3Origin recognition complex, subunit 3. (705 aa)
gins3GINS complex subunit 3. (211 aa)
meiobMethionine sulfoxide reductase B1b. (456 aa)
LOC102205179Fizzy/cell division cycle 20 related 1b. (487 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
anapc16Anaphase promoting complex subunit 16. (108 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (951 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
ENSPNYP00000005212Ubiquitin-like domain-containing protein. (114 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (332 aa)
ENSPNYP00000004124Proteasome inhibitor subunit 1. (236 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
LOC102214802Proteasome activator subunit 4b. (1804 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
psmb2Proteasome subunit beta. (199 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
psma2Proteasome subunit alpha type. (234 aa)
ENSPNYP00000017722Cullin 1b; Belongs to the cullin family. (370 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (389 aa)
anapc15Anaphase promoting complex subunit 15. (122 aa)
psma8Proteasome subunit alpha type. (251 aa)
psme1Proteasome activator subunit 1. (301 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
LOC102210761Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
LOC102210455UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
atad5AAA domain-containing protein. (746 aa)
kxd1KxDL motif containing 1. (184 aa)
lig1DNA ligase. (1012 aa)
ube2sUbiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (233 aa)
anapc5Anaphase promoting complex subunit 5. (721 aa)
psme3Proteasome activator subunit 3. (256 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (378 aa)
LOC102205503Proteasome subunit alpha type. (248 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (392 aa)
LOC102209997Proteasome 26S subunit, non-ATPase 11b. (422 aa)
LOC102207116Cyclin A2; Belongs to the cyclin family. (440 aa)
ENSPNYP00000028654Uncharacterized protein. (295 aa)
fam89aFamily with sequence similarity 89 member A. (180 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
ENSPNYP00000028993SCY domain-containing protein. (124 aa)
LOC102199978Proteasome subunit alpha type. (246 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
psme2Proteasome activator subunit 2. (245 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
psma6Proteasome subunit alpha type. (246 aa)
rfc1Replication factor C subunit 1. (1153 aa)
cdc6Cell division cycle 6 homolog (S. cerevisiae). (434 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (396 aa)
ENSPNYP00000031825Proteasome 26S subunit, non-ATPase 10. (138 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
Your Current Organism:
Pundamilia nyererei
NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei
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