(31 nodes) One carbon pool by folate network (Pundamilia nyererei)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	LOC102215808	PNPLA domain-containing protein. (823 aa)
	atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (591 aa)
	tyms	Thymidylate synthetase. (326 aa)
	LOC102214435	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (934 aa)
	TSTD2	Thiosulfate sulfurtransferase like domain containing 2. (463 aa)
	smarcd3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b. (517 aa)
	mthfs	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (200 aa)
	ENSPNYP00000005579	Queuine tRNA-ribosyltransferase accessory subunit 2. (259 aa)
	ENSPNYP00000005599	TGT domain-containing protein. (127 aa)
	mthfd2l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (348 aa)
	LOC102210696	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
	LOC102194385	Patatin-like phospholipase domain containing 8. (777 aa)
	qtrt1	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (397 aa)
	amt	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (418 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (455 aa)
	LOC102194749	Zgc:153901. (330 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (935 aa)
	LOC102194456	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (500 aa)
	LOC102209485	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (482 aa)
	LOC102200789	Uncharacterized protein. (360 aa)
	ftcd	Formimidoyltransferase cyclodeaminase. (539 aa)
	mthfsd	Methenyltetrahydrofolate synthetase domain containing. (396 aa)
	LOC102215246	PNPLA domain-containing protein. (880 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (482 aa)
	mtr	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1269 aa)
	dhfr	Dihydrofolate reductase. (189 aa)
	aldh1l2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (658 aa)
	LOC102211685	Zgc:153031. (198 aa)
	gart	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1017 aa)
	ovca2	OVCA2 serine hydrolase domain containing. (225 aa)

Your Current Organism:

Pundamilia nyererei

NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPNYP00000005579	ENSPNYP00000005599	ENSPNYP00000005579	ENSPNYP00000005599	Queuine tRNA-ribosyltransferase accessory subunit 2.	TGT domain-containing protein.	0.879
ENSPNYP00000005579	LOC102194456	ENSPNYP00000005579	ENSPNYP00000017712	Queuine tRNA-ribosyltransferase accessory subunit 2.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.504
ENSPNYP00000005579	LOC102200789	ENSPNYP00000005579	ENSPNYP00000019317	Queuine tRNA-ribosyltransferase accessory subunit 2.	Uncharacterized protein.	0.597
ENSPNYP00000005579	LOC102209485	ENSPNYP00000005579	ENSPNYP00000018774	Queuine tRNA-ribosyltransferase accessory subunit 2.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.504
ENSPNYP00000005579	LOC102211685	ENSPNYP00000005579	ENSPNYP00000028484	Queuine tRNA-ribosyltransferase accessory subunit 2.	Zgc:153031.	0.519
ENSPNYP00000005579	SHMT2	ENSPNYP00000005579	ENSPNYP00000014441	Queuine tRNA-ribosyltransferase accessory subunit 2.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.504
ENSPNYP00000005579	dhfr	ENSPNYP00000005579	ENSPNYP00000026164	Queuine tRNA-ribosyltransferase accessory subunit 2.	Dihydrofolate reductase.	0.519
ENSPNYP00000005579	mthfd2l	ENSPNYP00000005579	ENSPNYP00000006791	Queuine tRNA-ribosyltransferase accessory subunit 2.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.597
ENSPNYP00000005579	mthfr	ENSPNYP00000005579	ENSPNYP00000028309	Queuine tRNA-ribosyltransferase accessory subunit 2.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.485
ENSPNYP00000005579	qtrt1	ENSPNYP00000005579	ENSPNYP00000011161	Queuine tRNA-ribosyltransferase accessory subunit 2.	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]	0.980
ENSPNYP00000005579	shmt1	ENSPNYP00000005579	ENSPNYP00000024610	Queuine tRNA-ribosyltransferase accessory subunit 2.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.504
ENSPNYP00000005599	ENSPNYP00000005579	ENSPNYP00000005599	ENSPNYP00000005579	TGT domain-containing protein.	Queuine tRNA-ribosyltransferase accessory subunit 2.	0.879
ENSPNYP00000005599	LOC102194456	ENSPNYP00000005599	ENSPNYP00000017712	TGT domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.504
ENSPNYP00000005599	LOC102200789	ENSPNYP00000005599	ENSPNYP00000019317	TGT domain-containing protein.	Uncharacterized protein.	0.597
ENSPNYP00000005599	LOC102209485	ENSPNYP00000005599	ENSPNYP00000018774	TGT domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.504
ENSPNYP00000005599	LOC102211685	ENSPNYP00000005599	ENSPNYP00000028484	TGT domain-containing protein.	Zgc:153031.	0.519
ENSPNYP00000005599	SHMT2	ENSPNYP00000005599	ENSPNYP00000014441	TGT domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.504
ENSPNYP00000005599	dhfr	ENSPNYP00000005599	ENSPNYP00000026164	TGT domain-containing protein.	Dihydrofolate reductase.	0.519
ENSPNYP00000005599	mthfd2l	ENSPNYP00000005599	ENSPNYP00000006791	TGT domain-containing protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.597
ENSPNYP00000005599	mthfr	ENSPNYP00000005599	ENSPNYP00000028309	TGT domain-containing protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.485