STRINGSTRING
mcm2 mcm2 rnaseh1 rnaseh1 LOC102195724 LOC102195724 ENSPNYP00000000493 ENSPNYP00000000493 pola1 pola1 ENSPNYP00000010826 ENSPNYP00000010826 ENSPNYP00000011046 ENSPNYP00000011046 LOC102208887 LOC102208887 ENSPNYP00000011068 ENSPNYP00000011068 pold1 pold1 ENSPNYP00000011626 ENSPNYP00000011626 pcna pcna cpne2 cpne2 rpa3 rpa3 chrac1 chrac1 LOC102199648 LOC102199648 rfc4 rfc4 LOC102203422 LOC102203422 cpne7 cpne7 yju2 yju2 shd shd rnaseh2b rnaseh2b rfc3 rfc3 LOC102195025 LOC102195025 ENSPNYP00000018522 ENSPNYP00000018522 ENSPNYP00000018622 ENSPNYP00000018622 rpa2 rpa2 wrnip1 wrnip1 rnaseh2c rnaseh2c macrod1 macrod1 mcm4 mcm4 ENSPNYP00000020122 ENSPNYP00000020122 LOC102211335 LOC102211335 pola2 pola2 pold3 pold3 dna2 dna2 LOC102215177 LOC102215177 mcm6 mcm6 LOC102209807 LOC102209807 pole pole pole2 pole2 pold2 pold2 stn1 stn1 macrod2 macrod2 prim2 prim2 meiob meiob prim1 prim1 mcm3 mcm3 ssbp1 ssbp1 pole4 pole4 exoc8 exoc8 prkrip1 prkrip1 gen1 gen1 ENSPNYP00000029339 ENSPNYP00000029339 LOC102207121 LOC102207121 LOC102199173 LOC102199173 ENSPNYP00000029994 ENSPNYP00000029994 rfc1 rfc1 LOC102194738 LOC102194738 rnaseh2a rnaseh2a RPA1 RPA1 CPNE3 CPNE3 CPNE3-2 CPNE3-2 cpne3 cpne3 LOC102194415 LOC102194415 rfc5 rfc5 tor2a tor2a pold4 pold4 mcm7 mcm7 tor3a tor3a CPNE9 CPNE9 ENSPNYP00000009075 ENSPNYP00000009075 ENSPNYP00000008693 ENSPNYP00000008693 gdap2 gdap2 CPNE8 CPNE8 rfc2 rfc2 fam162a fam162a sass6 sass6 ENSPNYP00000004608 ENSPNYP00000004608 ENSPNYP00000004592 ENSPNYP00000004592 ENSPNYP00000004568 ENSPNYP00000004568 fen1 fen1 tor4a tor4a ENSPNYP00000004059 ENSPNYP00000004059 pole3 pole3 MCMDC2 MCMDC2 atad5 atad5 LOC102193169 LOC102193169 LOC102208360 LOC102208360 lig1 lig1 LOC102208864 LOC102208864 ENSPNYP00000002121 ENSPNYP00000002121 LOC102207756 LOC102207756
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
rnaseh1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (309 aa)
LOC102195724Zgc:110269. (323 aa)
ENSPNYP00000000493Uncharacterized protein. (80 aa)
pola1DNA polymerase. (1364 aa)
ENSPNYP00000010826Poly [ADP-ribose] polymerase. (293 aa)
ENSPNYP00000011046Copine domain-containing protein. (107 aa)
LOC102208887Copine Vb. (559 aa)
ENSPNYP00000011068Copine IVb. (192 aa)
pold1DNA polymerase. (1105 aa)
ENSPNYP00000011626Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (162 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
cpne2Copine II. (547 aa)
rpa3Replication protein A3. (122 aa)
chrac1Chromatin accessibility complex subunit 1. (125 aa)
LOC102199648Copine VIII. (533 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
LOC102203422Si:dkey-102f14.5. (415 aa)
cpne7Copine VII. (543 aa)
yju2YJU2 splicing factor homolog. (340 aa)
shdSrc homology 2 domain containing transforming protein D, a. (406 aa)
rnaseh2bRibonuclease H2, subunit B. (306 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC102195025Poly [ADP-ribose] polymerase. (704 aa)
ENSPNYP00000018522Macro domain-containing protein. (308 aa)
ENSPNYP00000018622Uncharacterized protein. (967 aa)
rpa2Replication protein A2. (293 aa)
wrnip1WRN helicase interacting protein 1. (614 aa)
rnaseh2cRibonuclease H2, subunit C. (136 aa)
macrod1Mono-ADP ribosylhydrolase 1. (369 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
ENSPNYP00000020122Uncharacterized protein. (133 aa)
LOC102211335Copine IVa. (545 aa)
pola2Polymerase (DNA directed), alpha 2. (565 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (443 aa)
dna2DNA replication helicase/nuclease 2. (1036 aa)
LOC102215177Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
mcm6DNA helicase; Belongs to the MCM family. (825 aa)
LOC102209807Calcium binding protein 5a. (178 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2015 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (509 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa)
macrod2Macro domain-containing protein. (447 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
meiobMethionine sulfoxide reductase B1b. (456 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
ssbp1Single-stranded DNA binding protein 1. (147 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
exoc8Exocyst complex component 8. (686 aa)
prkrip1PRKR interacting protein 1. (193 aa)
gen1Chromo_2 domain-containing protein. (640 aa)
ENSPNYP00000029339Uncharacterized protein. (213 aa)
LOC102207121Uncharacterized protein. (774 aa)
LOC102199173Copine Va. (524 aa)
ENSPNYP00000029994Uncharacterized protein. (136 aa)
rfc1Replication factor C subunit 1. (1153 aa)
LOC102194738Poly [ADP-ribose] polymerase. (300 aa)
rnaseh2aRibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (309 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
CPNE3Copine 3. (541 aa)
CPNE3-2Copine 3. (541 aa)
cpne3Copine III. (558 aa)
LOC102194415Uncharacterized protein. (161 aa)
rfc5Replication factor C (activator 1) 5. (342 aa)
tor2aTorsin. (311 aa)
pold4Si:dkey-28b4.7. (107 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (723 aa)
tor3aTorsin family 3, member A. (367 aa)
CPNE9Copine family member 9. (522 aa)
ENSPNYP00000009075Poly [ADP-ribose] polymerase. (1473 aa)
ENSPNYP00000008693RAD17 checkpoint clamp loader component. (445 aa)
gdap2Ganglioside induced differentiation associated protein 2. (496 aa)
CPNE8Copine 8. (564 aa)
rfc2Replication factor C (activator 1) 2. (356 aa)
fam162aFamily with sequence similarity 162 member A. (159 aa)
sass6SAS-6 centriolar assembly protein. (521 aa)
ENSPNYP00000004608Macro domain-containing protein. (281 aa)
ENSPNYP00000004592Poly [ADP-ribose] polymerase. (332 aa)
ENSPNYP00000004568Macro domain-containing protein. (265 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
tor4aTorsin family 4, member Aa. (441 aa)
ENSPNYP00000004059Copine family member IX. (521 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
MCMDC2Minichromosome maintenance domain containing 2. (635 aa)
atad5AAA domain-containing protein. (746 aa)
LOC102193169Copine I. (535 aa)
LOC102208360Torsin. (337 aa)
lig1DNA ligase. (1012 aa)
LOC102208864Poly [ADP-ribose] polymerase. (658 aa)
ENSPNYP00000002121Uncharacterized protein. (117 aa)
LOC102207756Poly [ADP-ribose] polymerase. (1719 aa)
Your Current Organism:
Pundamilia nyererei
NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.