45 items (Pundamilia nyererei) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	yju2	YJU2 splicing factor homolog. (340 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
	rfc1	Replication factor C subunit 1. (1153 aa)
	msh4	MutS homolog 4. (801 aa)
	prkrip1	PRKR interacting protein 1. (193 aa)
	ENSPNYP00000028465	Uncharacterized protein. (258 aa)
	ssbp1	Single-stranded DNA binding protein 1. (147 aa)
	ENSPNYP00000028455	Uncharacterized protein. (112 aa)
	meiob	Methionine sulfoxide reductase B1b. (456 aa)
	pms2	PMS1 homolog 2, mismatch repair system component. (860 aa)
	ENSPNYP00000024938	Uncharacterized protein. (79 aa)
	msh5	MutS homolog 5. (525 aa)
	stn1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1379 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
	ENSPNYP00000024046	MutS_I domain-containing protein. (321 aa)
	ENSPNYP00000024036	MutS homolog 3 (E. coli). (484 aa)
	LOC102209807	Calcium binding protein 5a. (178 aa)
	LOC102215177	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (443 aa)
	fbh1	F-box DNA helicase 1. (908 aa)
	rpa2	Replication protein A2. (293 aa)
	ENSPNYP00000018622	Uncharacterized protein. (967 aa)
	rexo4	REX4 homolog, 3'-5' exonuclease. (427 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	shd	Src homology 2 domain containing transforming protein D, a. (406 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (699 aa)
	pms1	PMS1 homolog 1, mismatch repair system component. (897 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	ISG20L2	Interferon stimulated exonuclease gene 20 like 2. (308 aa)
	rpa3	Replication protein A3. (122 aa)
	LOC102207961	Interferon stimulated exonuclease gene. (347 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	ENSPNYP00000011626	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (162 aa)
	pold1	DNA polymerase. (1105 aa)
	LOC102194415	Uncharacterized protein. (161 aa)
	rfc5	Replication factor C (activator 1) 5. (342 aa)
	pold4	Si:dkey-28b4.7. (107 aa)
	ENSPNYP00000008693	RAD17 checkpoint clamp loader component. (445 aa)
	rfc2	Replication factor C (activator 1) 2. (356 aa)
	sass6	SAS-6 centriolar assembly protein. (521 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (935 aa)
	exo1	Exonuclease 1. (767 aa)
	atad5	AAA domain-containing protein. (746 aa)
	lig1	DNA ligase. (1012 aa)

Your Current Organism:

Pundamilia nyererei

NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPNYP00000008693	ENSPNYP00000018622	ENSPNYP00000008693	ENSPNYP00000018622	RAD17 checkpoint clamp loader component.	Uncharacterized protein.	0.938
ENSPNYP00000008693	ENSPNYP00000024938	ENSPNYP00000008693	ENSPNYP00000024938	RAD17 checkpoint clamp loader component.	Uncharacterized protein.	0.401
ENSPNYP00000008693	ENSPNYP00000028455	ENSPNYP00000008693	ENSPNYP00000028455	RAD17 checkpoint clamp loader component.	Uncharacterized protein.	0.464
ENSPNYP00000008693	ENSPNYP00000028465	ENSPNYP00000008693	ENSPNYP00000028465	RAD17 checkpoint clamp loader component.	Uncharacterized protein.	0.464
ENSPNYP00000008693	ISG20L2	ENSPNYP00000008693	ENSPNYP00000014973	RAD17 checkpoint clamp loader component.	Interferon stimulated exonuclease gene 20 like 2.	0.631
ENSPNYP00000008693	LOC102207961	ENSPNYP00000008693	ENSPNYP00000013463	RAD17 checkpoint clamp loader component.	Interferon stimulated exonuclease gene.	0.631
ENSPNYP00000008693	LOC102215177	ENSPNYP00000008693	ENSPNYP00000021640	RAD17 checkpoint clamp loader component.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.924
ENSPNYP00000008693	RPA1	ENSPNYP00000008693	ENSPNYP00000032019	RAD17 checkpoint clamp loader component.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.924
ENSPNYP00000008693	atad5	ENSPNYP00000008693	ENSPNYP00000003041	RAD17 checkpoint clamp loader component.	AAA domain-containing protein.	0.938
ENSPNYP00000008693	exo1	ENSPNYP00000008693	ENSPNYP00000004440	RAD17 checkpoint clamp loader component.	Exonuclease 1.	0.911
ENSPNYP00000008693	lig1	ENSPNYP00000008693	ENSPNYP00000002573	RAD17 checkpoint clamp loader component.	DNA ligase.	0.883
ENSPNYP00000008693	meiob	ENSPNYP00000008693	ENSPNYP00000027578	RAD17 checkpoint clamp loader component.	Methionine sulfoxide reductase B1b.	0.907
ENSPNYP00000008693	mlh1	ENSPNYP00000008693	ENSPNYP00000016193	RAD17 checkpoint clamp loader component.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.590
ENSPNYP00000008693	msh2	ENSPNYP00000008693	ENSPNYP00000004559	RAD17 checkpoint clamp loader component.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.407
ENSPNYP00000008693	msh5	ENSPNYP00000008693	ENSPNYP00000024916	RAD17 checkpoint clamp loader component.	MutS homolog 5.	0.401
ENSPNYP00000008693	pcna	ENSPNYP00000008693	ENSPNYP00000011905	RAD17 checkpoint clamp loader component.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.981
ENSPNYP00000008693	pms1	ENSPNYP00000008693	ENSPNYP00000016181	RAD17 checkpoint clamp loader component.	PMS1 homolog 1, mismatch repair system component.	0.464
ENSPNYP00000008693	pms2	ENSPNYP00000008693	ENSPNYP00000026293	RAD17 checkpoint clamp loader component.	PMS1 homolog 2, mismatch repair system component.	0.464
ENSPNYP00000008693	pold1	ENSPNYP00000008693	ENSPNYP00000011516	RAD17 checkpoint clamp loader component.	DNA polymerase.	0.835
ENSPNYP00000008693	pold2	ENSPNYP00000008693	ENSPNYP00000024214	RAD17 checkpoint clamp loader component.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.841