STRINGSTRING
ENSPNYP00000011819 ENSPNYP00000011819 atrx atrx ficd ficd rad50 rad50 rad51 rad51 ENSPNYP00000019133 ENSPNYP00000019133 ENSPNYP00000018878 ENSPNYP00000018878 LOC102204862 LOC102204862 rpa2 rpa2 babam1 babam1 shd shd yju2 yju2 rad51d rad51d ENSPNYP00000015524 ENSPNYP00000015524 LOC102209078 LOC102209078 CNP CNP atm atm LOC102203240 LOC102203240 rpa3 rpa3 abraxas1 abraxas1 helq helq eme1 eme1 ENSPNYP00000021180 ENSPNYP00000021180 slc4a1ap slc4a1ap babam2 babam2 ENSPNYP00000000749 ENSPNYP00000000749 rtel1 rtel1 brca1 brca1 pif1 pif1 ENSPNYP00000003790 ENSPNYP00000003790 ENSPNYP00000003798 ENSPNYP00000003798 rad54l rad54l topbp1 topbp1 abraxas2 abraxas2 sass6 sass6 MPHOSPH9 MPHOSPH9 unc93b1 unc93b1 LOC102203164 LOC102203164 LOC102208891 LOC102208891 ENSPNYP00000006654 ENSPNYP00000006654 ENSPNYP00000006833 ENSPNYP00000006833 nbn nbn mcfd2 mcfd2 ENSPNYP00000008349 ENSPNYP00000008349 xrcc3 xrcc3 ENSPNYP00000009293 ENSPNYP00000009293 pithd1 pithd1 pold4 pold4 pold1 pold1 ENSPNYP00000011626 ENSPNYP00000011626 RPA1 RPA1 ENSPNYP00000031920 ENSPNYP00000031920 top3a top3a brip1 brip1 sycp3 sycp3 n4bp2 n4bp2 prkrip1 prkrip1 xrcc2 xrcc2 ssbp1 ssbp1 slf1 slf1 ENSPNYP00000027817 ENSPNYP00000027817 ENSPNYP00000027806 ENSPNYP00000027806 ddx52 ddx52 ENSPNYP00000027632 ENSPNYP00000027632 meiob meiob top3b top3b LOC102198009 LOC102198009 sap130 sap130 sem1 sem1 bard1 bard1 ENSPNYP00000025405 ENSPNYP00000025405 stn1 stn1 ENSPNYP00000024291 ENSPNYP00000024291 rad54b rad54b mre11 mre11 pold2 pold2 recql5 recql5 LOC102211751 LOC102211751 unc93a unc93a LOC102215177 LOC102215177 pold3 pold3 PTGDR2 PTGDR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPNYP00000011819RecQ helicase-like 4. (765 aa)
atrxATRX chromatin remodeler. (1840 aa)
ficdFIC domain containing. (450 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
ENSPNYP00000019133RAP80_UIM domain-containing protein. (609 aa)
ENSPNYP00000018878Leucine rich adaptor protein 1. (247 aa)
LOC102204862MUS81 structure-specific endonuclease subunit. (500 aa)
rpa2Replication protein A2. (293 aa)
babam1BRISC and BRCA1 A complex member 1. (326 aa)
shdSrc homology 2 domain containing transforming protein D, a. (406 aa)
yju2YJU2 splicing factor homolog. (340 aa)
rad51dRAD51 paralog D. (333 aa)
ENSPNYP00000015524Uncharacterized protein. (1445 aa)
LOC102209078Uncharacterized protein. (256 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (638 aa)
atmNon-specific serine/threonine protein kinase. (3051 aa)
LOC102203240BLM RecQ like helicase. (1339 aa)
rpa3Replication protein A3. (122 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (346 aa)
helqHelicase, POLQ like. (912 aa)
eme1Essential meiotic structure-specific endonuclease 1. (527 aa)
ENSPNYP00000021180BRCA1/BRCA2-containing complex, subunit 3. (278 aa)
slc4a1apSolute carrier family 4 member 1 adaptor protein. (783 aa)
babam2BRISC and BRCA1 A complex member 2. (400 aa)
ENSPNYP00000000749Uncharacterized protein. (95 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1137 aa)
brca1Uncharacterized protein. (1180 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (626 aa)
ENSPNYP00000003790Uncharacterized protein. (134 aa)
ENSPNYP00000003798Uncharacterized protein. (117 aa)
rad54lRAD54 like. (719 aa)
topbp1DNA topoisomerase II binding protein 1. (1425 aa)
abraxas2Abraxas 2, BRISC complex subunit. (451 aa)
sass6SAS-6 centriolar assembly protein. (521 aa)
MPHOSPH9M-phase phosphoprotein 9. (1262 aa)
unc93b1Unc-93 homolog B1, TLR signaling regulator. (624 aa)
LOC102203164G_PROTEIN_RECEP_F1_2 domain-containing protein. (448 aa)
LOC102208891ERCC4 domain-containing protein. (398 aa)
ENSPNYP00000006654Reverse transcriptase domain-containing protein. (471 aa)
ENSPNYP00000006833Uncharacterized protein. (255 aa)
nbnNibrin. (776 aa)
mcfd2Multiple coagulation factor deficiency 2. (153 aa)
ENSPNYP00000008349Reverse transcriptase domain-containing protein. (163 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (342 aa)
ENSPNYP00000009293SURP motif domain-containing protein. (312 aa)
pithd1PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1. (209 aa)
pold4Si:dkey-28b4.7. (107 aa)
pold1DNA polymerase. (1105 aa)
ENSPNYP00000011626Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (162 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
ENSPNYP00000031920Ig-like domain-containing protein. (308 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
brip1BRCA1 interacting protein C-terminal helicase 1. (1159 aa)
sycp3Synaptonemal complex protein 3. (242 aa)
n4bp2NEDD4 binding protein 2. (1692 aa)
prkrip1PRKR interacting protein 1. (193 aa)
xrcc2X-ray repair cross complementing 2. (301 aa)
ssbp1Single-stranded DNA binding protein 1. (147 aa)
slf1SMC5-SMC6 complex localization factor 1. (722 aa)
ENSPNYP00000027817Microcephalin 1. (449 aa)
ENSPNYP00000027806Uncharacterized protein. (1760 aa)
ddx52DEAD (Asp-Glu-Ala-Asp) box polypeptide 52. (581 aa)
ENSPNYP00000027632SAE2 domain-containing protein. (75 aa)
meiobMethionine sulfoxide reductase B1b. (456 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (856 aa)
LOC102198009RAD51 paralog C. (358 aa)
sap130Sin3A-associated protein a. (981 aa)
sem1SEM1 26S proteasome complex subunit. (70 aa)
bard1BRCA1 associated RING domain 1. (641 aa)
ENSPNYP00000025405Uncharacterized protein. (98 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa)
ENSPNYP00000024291Uncharacterized protein. (66 aa)
rad54bRAD54 homolog B. (814 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (689 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
recql5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (870 aa)
LOC102211751Si:ch211-125a15.1. (448 aa)
unc93aUnc-93 homolog A. (464 aa)
LOC102215177Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (443 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (318 aa)
Your Current Organism:
Pundamilia nyererei
NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei
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