STRINGSTRING
ei24 ei24 LOC102199967 LOC102199967 siva1 siva1 LOC102198839 LOC102198839 GADD45B GADD45B tsc2 tsc2 ENSPNYP00000001542 ENSPNYP00000001542 perp perp apaf1 apaf1 rprm rprm ENSPNYP00000003050 ENSPNYP00000003050 ENSPNYP00000003091 ENSPNYP00000003091 LOC102200854 LOC102200854 LOC102205568 LOC102205568 LOC102200870 LOC102200870 cdk1 cdk1 LOC102210938 LOC102210938 RRM2 RRM2 RRM2-2 RRM2-2 ENSPNYP00000006031 ENSPNYP00000006031 LOC102211839 LOC102211839 gorab gorab ENSPNYP00000007856 ENSPNYP00000007856 ENSPNYP00000007911 ENSPNYP00000007911 ENSPNYP00000008465 ENSPNYP00000008465 LOC102212492 LOC102212492 LOC102206726 LOC102206726 ENSPNYP00000008816 ENSPNYP00000008816 atr atr LOC102192516 LOC102192516 ccnd3 ccnd3 STEAP3 STEAP3 rchy1 rchy1 TP53I3 TP53I3 LOC102195352 LOC102195352 LOC102196963 LOC102196963 ENSPNYP00000011812 ENSPNYP00000011812 steap2 steap2 bcl2l1 bcl2l1 tp73 tp73 LOC102196880 LOC102196880 LOC102213444 LOC102213444 LOC102205879 LOC102205879 cop1 cop1 chek1 chek1 atm atm ENSPNYP00000015235 ENSPNYP00000015235 casp9 casp9 LOC102195282 LOC102195282 LOC102205505 LOC102205505 cryz cryz bcl2 bcl2 LOC102197210 LOC102197210 LOC102207375 LOC102207375 GADD45B-2 GADD45B-2 cntd2 cntd2 IGFBP3 IGFBP3 LOC102192940 LOC102192940 LOC102215705 LOC102215705 ccnd1 ccnd1 zmat3 zmat3 LOC102210782 LOC102210782 ENSPNYP00000019551 ENSPNYP00000019551 ENSPNYP00000019563 ENSPNYP00000019563 ddb2 ddb2 LOC102200724 LOC102200724 LOC102192873 LOC102192873 ENSPNYP00000020496 ENSPNYP00000020496 LOC102195846 LOC102195846 gadd45g gadd45g hps5 hps5 LOC102209424 LOC102209424 LOC102213524 LOC102213524 LOC102213811 LOC102213811 LOC102203740 LOC102203740 LOC102199580 LOC102199580 ccnb1 ccnb1 pten pten mdm2 mdm2 CCNG2 CCNG2 adgrb1 adgrb1 mdm4 mdm4 LOC102198008 LOC102198008 LOC102207644 LOC102207644 cdk6 cdk6 LOC102212727 LOC102212727 fam76b fam76b adgrb3 adgrb3 LOC102210818 LOC102210818 cdk2 cdk2 ccne1 ccne1 cdk4 cdk4 ENSPNYP00000027362 ENSPNYP00000027362 LOC102192446 LOC102192446 adgrb2 adgrb2 GADD45A GADD45A LOC102199243 LOC102199243 LOC102192369 LOC102192369 sesn1 sesn1 thbs1 thbs1 igf1 igf1 ENSPNYP00000030520 ENSPNYP00000030520 LOC102204259 LOC102204259 ppm1d ppm1d LOC102209904 LOC102209904 ENSPNYP00000032018 ENSPNYP00000032018 CASP3 CASP3 CASP3-2 CASP3-2 cenpu cenpu ccng1 ccng1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ei24EI24 autophagy associated transmembrane protein. (340 aa)
LOC102199967Tumor necrosis factor receptor superfamily, member a. (450 aa)
siva1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (164 aa)
LOC102198839Transmembrane phosphatase with tensin homology. (451 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
tsc2TSC complex subunit 2. (1740 aa)
ENSPNYP00000001542Ribosomal_L7Ae domain-containing protein. (200 aa)
perpP53 apoptosis effector related to pmp22. (184 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1258 aa)
rprmReprimo, TP53 dependent G2 arrest mediator candidate b. (102 aa)
ENSPNYP00000003050Uncharacterized protein. (182 aa)
ENSPNYP00000003091Protein kinase domain-containing protein. (69 aa)
LOC102200854Thrombospondin 1b. (1168 aa)
LOC102205568Growth arrest and DNA-damage-inducible, alpha, a. (163 aa)
LOC102200870Tetraspanin. (237 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (276 aa)
LOC102210938Zgc:153993. (203 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (385 aa)
RRM2-2Ribonucleotide reductase regulatory subunit M2. (385 aa)
ENSPNYP00000006031Pyr_redox_2 domain-containing protein. (110 aa)
LOC102211839E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (332 aa)
gorabGolgin, rab6-interacting. (341 aa)
ENSPNYP00000007856Uncharacterized protein. (364 aa)
ENSPNYP00000007911Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (300 aa)
ENSPNYP00000008465Uncharacterized protein. (331 aa)
LOC102212492Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (464 aa)
LOC102206726Uncharacterized protein. (181 aa)
ENSPNYP00000008816Tumor protein p53. (357 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2444 aa)
LOC102192516Cyclin-dependent kinase inhibitor 1A. (169 aa)
ccnd3Cyclin D3; Belongs to the cyclin family. (254 aa)
STEAP3STEAP3 metalloreductase. (489 aa)
rchy1Ring finger and CHY zinc finger domain containing 1. (260 aa)
TP53I3Tumor protein p53 inducible protein 3. (367 aa)
LOC102195352Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC102196963Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (468 aa)
ENSPNYP00000011812Cyclin B2; Belongs to the cyclin family. (258 aa)
steap2STEAP family member 2, metalloreductase. (487 aa)
bcl2l1BCL2 like 1. (233 aa)
tp73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (644 aa)
LOC102196880BCL2 associated X, apoptosis regulator a. (205 aa)
LOC102213444Sestrin 2. (583 aa)
LOC102205879Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (242 aa)
cop1COP1 E3 ubiquitin ligase. (714 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (215 aa)
atmNon-specific serine/threonine protein kinase. (3051 aa)
ENSPNYP00000015235GTSE1_N domain-containing protein. (468 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (415 aa)
LOC102195282Reprimo-like. (99 aa)
LOC102205505Ribonucleotide reductase M2 b. (349 aa)
cryzCrystallin, zeta (quinone reductase). (249 aa)
bcl2BCL2 apoptosis regulator b. (228 aa)
LOC102197210Adhesion G protein-coupled receptor B1b; Belongs to the G-protein coupled receptor 2 family. (1468 aa)
LOC102207375Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (303 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (153 aa)
cntd2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (361 aa)
IGFBP3Insulin like growth factor binding protein 3. (286 aa)
LOC102192940Si:zfos-80g12.1. (432 aa)
LOC102215705Checkpoint kinase 2. (476 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
zmat3Zinc finger, matrin-type 3. (274 aa)
LOC102210782Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
ENSPNYP00000019551Uncharacterized protein. (148 aa)
ENSPNYP00000019563Uncharacterized protein. (77 aa)
ddb2Damage-specific DNA binding protein 2. (490 aa)
LOC102200724Cyclin G2; Belongs to the cyclin family. (334 aa)
LOC102192873P53-induced death domain protein 1. (883 aa)
ENSPNYP00000020496Uncharacterized protein. (327 aa)
LOC102195846Cyclin E2; Belongs to the cyclin family. (380 aa)
gadd45gGrowth arrest and DNA-damage-inducible, gamma a. (159 aa)
hps5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1122 aa)
LOC102209424Cyclin Dx; Belongs to the cyclin family. (296 aa)
LOC102213524Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (154 aa)
LOC102213811Ribosomal_L7Ae domain-containing protein. (157 aa)
LOC102203740Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
LOC102199580Cyclin D2, b; Belongs to the cyclin family. (294 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (367 aa)
ptenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (411 aa)
mdm2MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (457 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (334 aa)
adgrb1Adhesion G protein-coupled receptor B1a; Belongs to the G-protein coupled receptor 2 family. (1496 aa)
mdm4MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (495 aa)
LOC102198008Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (293 aa)
LOC102207644BH4_2 domain-containing protein. (226 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
LOC102212727Protein phosphatase, Mg2+/Mn2+ dependent, 1Db. (570 aa)
fam76bFamily with sequence similarity 76 member B. (334 aa)
adgrb3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1524 aa)
LOC102210818Cyclin D2, a; Belongs to the cyclin family. (297 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (432 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (318 aa)
ENSPNYP00000027362Uncharacterized protein. (103 aa)
LOC102192446IlGF domain-containing protein. (182 aa)
adgrb2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1399 aa)
GADD45AGrowth arrest and DNA-damage-inducible, alpha, b. (154 aa)
LOC102199243BH4_2 domain-containing protein. (198 aa)
LOC102192369Tetraspanin. (255 aa)
sesn1Sestrin 1. (547 aa)
thbs1Thrombospondin 1a. (1170 aa)
igf1Insulin-like growth factor 1. (182 aa)
ENSPNYP00000030520Uncharacterized protein. (184 aa)
LOC102204259E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (199 aa)
ppm1dProtein phosphatase, Mg2+/Mn2+ dependent, 1Da. (520 aa)
LOC102209904Insulin-like growth factor binding protein 3. (283 aa)
ENSPNYP00000032018CARD domain-containing protein. (142 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (316 aa)
CASP3-2Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (291 aa)
cenpuUncharacterized protein. (439 aa)
ccng1Cyclin G1; Belongs to the cyclin family. (299 aa)
Your Current Organism:
Pundamilia nyererei
NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei
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