(109 nodes) Adipocytokine signaling pathway network (Pundamilia nyererei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102207122	AMP-binding domain-containing protein. (722 aa)
	RXRB	Uncharacterized protein. (470 aa)
	acsbg1	Acyl-CoA synthetase bubblegum family member 1. (666 aa)
	LOC102195254	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (545 aa)
	LOC102213074	Tyrosine-protein kinase. (1120 aa)
	LOC102208859	TNF_2 domain-containing protein. (229 aa)
	acsl3	AMP-binding domain-containing protein. (719 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (592 aa)
	stat3	Signal transducer and activator of transcription. (784 aa)
	adipor2	Adiponectin receptor 2. (378 aa)
	LOC102205276	Mitogen-activated protein kinase. (456 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	LOC102214691	Insulin receptor substrate 2a. (1052 aa)
	LOC102195116	Uncharacterized protein. (217 aa)
	LOC102195906	Acyl-CoA synthetase long chain family member 3b. (711 aa)
	prkab1	Protein kinase, AMP-activated, beta 1 non-catalytic subunit, a. (269 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (548 aa)
	LOC102206922	Acyl-CoA synthetase long chain family member 1a. (697 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (268 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (396 aa)
	mapk10	Mitogen-activated protein kinase. (402 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1283 aa)
	rel	V-rel avian reticuloendotheliosis viral oncogene homolog. (622 aa)
	LOC102193219	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (504 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (475 aa)
	slc2a2	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (500 aa)
	G6PC2	Glucose-6-phosphatase catalytic subunit 2. (365 aa)
	nostrin	Nitric oxide synthase trafficking. (526 aa)
	LOC102215815	Solute carrier family 2 member 1b; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (490 aa)
	socs3	Suppressor of cytokine signaling 3. (230 aa)
	LOC102195641	Carnitine palmitoyltransferase 1B (muscle); Belongs to the carnitine/choline acetyltransferase family. (786 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
	g6pc3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (342 aa)
	LOC102200298	Tyrosine-protein kinase. (1122 aa)
	LOC102205282	Solute carrier family 2 member 3a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (480 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (506 aa)
	mapk8	Mitogen-activated protein kinase. (390 aa)
	LOC102209265	Protein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (268 aa)
	acsl5	Acyl-CoA synthetase long chain family member 5. (672 aa)
	prkag1	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (326 aa)
	g6pc	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
	LOC102214669	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa)
	ENSPNYP00000001933	Uncharacterized protein. (71 aa)
	LOC102200915	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
	LOC102193564	Uncharacterized protein. (153 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	LOC102209835	Solute carrier family 2 member 3b; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (501 aa)
	LOC102209963	Mitogen-activated protein kinase. (420 aa)
	acsl4	Acyl-CoA synthetase long chain family member 4a. (712 aa)
	LOC102199587	Acyl-CoA synthetase long chain family member 1b. (693 aa)
	LOC102206562	Protein tyrosine phosphatase non-receptor type 11b. (547 aa)
	LOC102201957	Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (785 aa)
	mtor	Serine/threonine-protein kinase TOR. (2485 aa)
	lepr	Leptin receptor. (1134 aa)
	tradd	Tnfrsf1a-associated via death domain. (330 aa)
	LOC102201584	Acyl-CoA synthetase long chain family member 2. (676 aa)
	LOC102209720	Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (292 aa)
	LOC102211317	Carnitine palmitoyltransferase 1Ab (liver); Belongs to the carnitine/choline acetyltransferase family. (771 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (720 aa)
	NPY	Neuropeptide Y. (98 aa)
	nfkb1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (884 aa)
	LOC102207774	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (284 aa)
	acacb	Acetyl-CoA carboxylase beta. (2375 aa)
	LOC102202936	Agouti domain-containing protein. (142 aa)
	LOC102196903	AMP-binding domain-containing protein. (678 aa)
	LOC102197083	Insulin receptor substrate 4a. (1410 aa)
	cd36	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (468 aa)
	tnfrsf14	Tumor necrosis factor receptor superfamily, member 1B. (491 aa)
	LOC102199942	Si:ch211-284e13.4. (1160 aa)
	LOC102206926	Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
	LOC102210873	Retinoid X receptor, alpha a. (499 aa)
	ENSPNYP00000025755	zf-C3HC4 domain-containing protein. (51 aa)
	LOC102193924	Carnitine palmitoyltransferase 1Cb; Belongs to the carnitine/choline acetyltransferase family. (788 aa)
	LOC102208435	V-rel avian reticuloendotheliosis viral oncogene homolog A. (611 aa)
	LOC102193793	Suppressor of cytokine signaling 3a. (205 aa)
	ENSPNYP00000026141	TNF_2 domain-containing protein. (216 aa)
	adipor1	Adiponectin receptor 1a. (376 aa)
	ENSPNYP00000026646	Neuropeptide Y. (111 aa)
	LOC102195437	Insulin receptor substrate 2b. (1103 aa)
	ENSPNYP00000027448	Protein kinase domain-containing protein. (102 aa)
	LOC102195172	Protein kinase domain-containing protein. (762 aa)
	LOC102200755	AMP-binding domain-containing protein. (766 aa)
	LOC102195260	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (493 aa)
	LOC102195226	Component of inhibitor of nuclear factor kappa B kinase complex. (734 aa)
	LOC102204648	Uncharacterized protein. (204 aa)
	ENSPNYP00000029225	CBS domain-containing protein. (257 aa)
	LOC102200245	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (305 aa)
	ENSPNYP00000029233	Uncharacterized protein. (224 aa)
	LOC102197086	Si:ch73-335l21.1. (1276 aa)
	LOC102214418	Uncharacterized protein. (453 aa)
	LOC102207098	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (475 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (318 aa)
	LOC102200009	Tumor necrosis factor receptor superfamily, member 1a. (394 aa)
	nfkbie	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon. (345 aa)
	LOC102192865	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
	ENSPNYP00000031331	PH domain-containing protein. (146 aa)
	POMC	Proopiomelanocortin. (201 aa)
	LOC102211307	acidPPc domain-containing protein. (309 aa)
	LOC102195756	Agouti domain-containing protein. (152 aa)
	LOC102200104	Uncharacterized protein. (298 aa)
	LOC102210745	Retinoid x receptor, beta b. (444 aa)
	acsbg2	Acyl-CoA synthetase bubblegum family member 2. (396 aa)
	LOC102213697	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	LOC102205878	Si:ch73-62l21.1. (514 aa)
	pck2	Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (655 aa)

Your Current Organism:

Pundamilia nyererei

NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPNYP00000001933	LOC102202936	ENSPNYP00000001933	ENSPNYP00000022829	Uncharacterized protein.	Agouti domain-containing protein.	0.913
ENSPNYP00000025755	ENSPNYP00000027448	ENSPNYP00000025755	ENSPNYP00000027448	zf-C3HC4 domain-containing protein.	Protein kinase domain-containing protein.	0.421
ENSPNYP00000025755	ENSPNYP00000031331	ENSPNYP00000025755	ENSPNYP00000031331	zf-C3HC4 domain-containing protein.	PH domain-containing protein.	0.421
ENSPNYP00000025755	LOC102192865	ENSPNYP00000025755	ENSPNYP00000031119	zf-C3HC4 domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.421
ENSPNYP00000025755	LOC102193219	ENSPNYP00000025755	ENSPNYP00000008792	zf-C3HC4 domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.809
ENSPNYP00000025755	LOC102195172	ENSPNYP00000025755	ENSPNYP00000027737	zf-C3HC4 domain-containing protein.	Protein kinase domain-containing protein.	0.704
ENSPNYP00000025755	LOC102195226	ENSPNYP00000025755	ENSPNYP00000028431	zf-C3HC4 domain-containing protein.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.825
ENSPNYP00000025755	LOC102200009	ENSPNYP00000025755	ENSPNYP00000030663	zf-C3HC4 domain-containing protein.	Tumor necrosis factor receptor superfamily, member 1a.	0.971
ENSPNYP00000025755	LOC102200298	ENSPNYP00000025755	ENSPNYP00000004183	zf-C3HC4 domain-containing protein.	Tyrosine-protein kinase.	0.405
ENSPNYP00000025755	LOC102200915	ENSPNYP00000025755	ENSPNYP00000001886	zf-C3HC4 domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.421
ENSPNYP00000025755	LOC102205276	ENSPNYP00000025755	ENSPNYP00000012994	zf-C3HC4 domain-containing protein.	Mitogen-activated protein kinase.	0.580
ENSPNYP00000025755	LOC102206926	ENSPNYP00000025755	ENSPNYP00000024693	zf-C3HC4 domain-containing protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.883
ENSPNYP00000025755	LOC102209963	ENSPNYP00000025755	ENSPNYP00000000403	zf-C3HC4 domain-containing protein.	Mitogen-activated protein kinase.	0.603
ENSPNYP00000025755	LOC102213074	ENSPNYP00000025755	ENSPNYP00000015864	zf-C3HC4 domain-containing protein.	Tyrosine-protein kinase.	0.405
ENSPNYP00000025755	LOC102213697	ENSPNYP00000025755	ENSPNYP00000017716	zf-C3HC4 domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.421
ENSPNYP00000025755	akt1	ENSPNYP00000025755	ENSPNYP00000001013	zf-C3HC4 domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.421
ENSPNYP00000025755	ikbkb	ENSPNYP00000025755	ENSPNYP00000010417	zf-C3HC4 domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.825
ENSPNYP00000025755	ikbkg	ENSPNYP00000025755	ENSPNYP00000011896	zf-C3HC4 domain-containing protein.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.847
ENSPNYP00000025755	mapk10	ENSPNYP00000025755	ENSPNYP00000009228	zf-C3HC4 domain-containing protein.	Mitogen-activated protein kinase.	0.580
ENSPNYP00000025755	mapk8	ENSPNYP00000025755	ENSPNYP00000003895	zf-C3HC4 domain-containing protein.	Mitogen-activated protein kinase.	0.580