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rplX rplX aif6 aif6 rpl31e rpl31e rpl39e rpl39e rps19e rps19e MCP_0045 MCP_0045 ef1b ef1b MCP_0197 MCP_0197 MCP_0206 MCP_0206 MCP_0213 MCP_0213 rps17e rps17e eif2g eif2g rpl10e rpl10e eif2b eif2b aif1a-1 aif1a-1 rpl21e rpl21e ksgA ksgA rpl40e rpl40e MCP_0829 MCP_0829 rps3Ae rps3Ae map-1 map-1 MCP_1003 MCP_1003 infB infB rpl24e rpl24e rps28e rps28e rpl7ae rpl7ae MCP_1049 MCP_1049 MCP_1050 MCP_1050 rpl30e rpl30e rps12p rps12p tuf tuf rps10p rps10p MCP_1465 MCP_1465 MCP_1531 MCP_1531 MCP_1532 MCP_1532 eif2a eif2a rps27e rps27e rpl44e rpl44e MCP_1556 MCP_1556 flpA flpA rps2p rps2p rps9p rps9p rpl13p rpl13p rpl18e rpl18e rps6e rps6e aif5A aif5A rps15p rps15p rps8e rps8e proS proS rrmJ rrmJ MCP_1891 MCP_1891 rpl12p rpl12p rplP0 rplP0 rpl1p rpl1p rpl11p rpl11p aif1a-2 aif1a-2 MCP_2117 MCP_2117 MCP_2142 MCP_2142 aif1a-3 aif1a-3 rpl3p rpl3p rpl4p rpl4p rpl23p rpl23p rpl2p rpl2p rps19p rps19p rpl22p rpl22p rps3p rps3p rpl29p rpl29p MCP_2228 MCP_2228 rps17p rps17p rpl14p rpl14p rpl24p rpl24p rps4e rps4e rpl5p rpl5p rps14p rps14p rps8p rps8p rpl6p rpl6p rpl32e rpl32e rpl19e rpl19e rpl18p rpl18p rps5p rps5p rpl30p rpl30p rpl15p rpl15p adk adk rps13p rps13p rps4p rps4p rps11p rps11p rpl37e rpl37e MCP_2339 MCP_2339 map-2 map-2 aif1a-4 aif1a-4 rtcA rtcA rpl37ae rpl37ae MCP_2629 MCP_2629 rpl15e rpl15e rps27ae rps27ae rps24e rps24e prf1 prf1 MCP_2962 MCP_2962 nac nac
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rplX50S ribosomal protein LX. (58 aa)
aif6Translation initiation factor 6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (220 aa)
rpl31e50S ribosomal protein L31e; Belongs to the ribosomal protein L31e family. (85 aa)
rpl39e50S ribosomal protein L39e; Belongs to the eukaryotic ribosomal protein eL39 family. (50 aa)
rps19e30S ribosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (151 aa)
MCP_0045GTP-binding protein. (338 aa)
ef1bElongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (88 aa)
MCP_0197Conserved hypothetical protein; Contains two Protein of unknown function DUF1610 domains (IPR011668). (55 aa)
MCP_0206Conserved hypothetical protein; Belongs to the NMD3 family (IPR007064). (358 aa)
MCP_0213RNase L inhibitor. (589 aa)
rps17e30S ribosomal protein S17e; Belongs to the eukaryotic ribosomal protein eS17 family. (65 aa)
eif2gTranslation initiation factor 2 gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (410 aa)
rpl10e50S ribosomal protein L10e; Belongs to the universal ribosomal protein uL16 family. (172 aa)
eif2bTranslation initiation factor 2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (205 aa)
aif1a-1Translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (79 aa)
rpl21e50S ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family. (102 aa)
ksgAProbable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (276 aa)
rpl40e50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. (48 aa)
MCP_0829Conserved hypothetical protein. (165 aa)
rps3Ae30S ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family. (227 aa)
map-1Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (296 aa)
MCP_1003Putative HTH-type transcriptional regulator; Belongs to the Conserved hypothetical protein 270 family (IPR004451). (167 aa)
infBProbable translation initiation factor 2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (593 aa)
rpl24e50S ribosomal protein L24e; Binds to the 23S rRNA. (71 aa)
rps28e30S ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family. (70 aa)
rpl7ae50S ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (123 aa)
MCP_1049NOL1/NOP2/sun family putative RNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (320 aa)
MCP_1050Conserved hypothetical protein; Belongs to the Protein of unknown function UPF0113 family (IPR005155). (175 aa)
rpl30e50S ribosomal protein L30e; Belongs to the eukaryotic ribosomal protein eL30 family. (104 aa)
rps12p30S ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (142 aa)
tufElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (426 aa)
rps10p30S ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (104 aa)
MCP_1465Putative serine/threonine kinase. (289 aa)
MCP_1531Putative serine/threonine kinase. (256 aa)
MCP_1532Conserved hypothetical protein; Contains one KH domain (IPR004087); Contains one KH, type 1 domain (IPR004088). (180 aa)
eif2aTranslation initiation factor 2 alpha subunit. (267 aa)
rps27e30S ribosomal protein S27e. (61 aa)
rpl44e50S ribosomal protein L44E; Binds to the 23S rRNA. (93 aa)
MCP_1556snoRNA binding protein Nop56 homolog. (248 aa)
flpArRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (222 aa)
rps2p30S ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (211 aa)
rps9p30S ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (134 aa)
rpl13p50S ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (139 aa)
rpl18e50S ribosomal protein L18e; Belongs to the eukaryotic ribosomal protein eL18 family. (120 aa)
rps6e30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family. (146 aa)
aif5ATranslation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (128 aa)
rps15p30S ribosomal protein S15P/S13e. (152 aa)
rps8e30S ribosomal protein S8e. (126 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (474 aa)
rrmJRibosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (254 aa)
MCP_1891GTP-binding protein. (524 aa)
rpl12p50S ribosomal protein L12P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (103 aa)
rplP0Acidic ribosomal protein P0 homolog; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (303 aa)
rpl1p50S ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (213 aa)
rpl11p50S ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (160 aa)
aif1a-2Translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (92 aa)
MCP_2117Hypothetical protein. (135 aa)
MCP_2142Ribose-1,5-bisphosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. (322 aa)
aif1a-3Translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (112 aa)
rpl3p50S ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (341 aa)
rpl4p50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (250 aa)
rpl23p50S ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (85 aa)
rpl2p50S ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (240 aa)
rps19p30S ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (140 aa)
rpl22p50S ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (155 aa)
rps3p30S ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (292 aa)
rpl29p50S ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (66 aa)
MCP_2228Protein translation factor SUI1 homolog; Belongs to the SUI1 family. (101 aa)
rps17p30S ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (110 aa)
rpl14p50S ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa)
rpl24p50S ribosomal protein L24P; Located at the polypeptide exit tunnel on the outside of the subunit. (124 aa)
rps4e30S ribosomal protein S4e; Belongs to the eukaryotic ribosomal protein eS4 family. (234 aa)
rpl5p50S ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (170 aa)
rps14p30S ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (50 aa)
rps8p30S ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpl6p50S ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpl32e50S ribosomal protein L32e. (219 aa)
rpl19e50S ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (147 aa)
rpl18p50S ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (188 aa)
rps5p30S ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (207 aa)
rpl30p50S ribosomal protein L30P. (153 aa)
rpl15p50S ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (149 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa)
rps13p30S ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (225 aa)
rps4p30S ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa)
rps11p30S ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (130 aa)
rpl37e50S ribosomal protein L37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (59 aa)
MCP_2339Protein translation factor SUI1 homolog; Belongs to the SUI1 family. (102 aa)
map-2Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (289 aa)
aif1a-4Translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (90 aa)
rtcARNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (340 aa)
rpl37ae50S ribosomal protein L37Ae; Binds to the 23S rRNA. (94 aa)
MCP_2629Conserved hypothetical protein; Belongs to the Shwachman-Bodian-Diamond syndrome proteins family (IPR002140). (231 aa)
rpl15e50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. (196 aa)
rps27ae30S ribosomal protein S27ae; Belongs to the eukaryotic ribosomal protein eS31 family. (76 aa)
rps24e30S ribosomal protein S24e; Belongs to the eukaryotic ribosomal protein eS24 family. (103 aa)
prf1Peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (415 aa)
MCP_2962Conserved hypothetical protein; Contains one Translation elongation factor EFTu/EF1A, domain 2 (IPR004161). (341 aa)
nacNascent polypeptide-associated complex protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. (117 aa)
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
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