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| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3420 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (978 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (902 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1172 aa) |
| | RAD51C | RAD51 paralog C. (442 aa) |
| | MLH1 | MutL homolog 1. (758 aa) |
| | ATRIP | ATR interacting protein. (789 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | WRN | WRN RecQ like helicase. (1409 aa) |
| | POLD4 | Uncharacterized protein. (315 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | MRE11 | MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa) |
| | MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (832 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa) |
| | A0A4W2C4K5 | RECA_2 domain-containing protein. (525 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (987 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (642 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (416 aa) |
| | A0A4W2C6P0 | Piezo_RRas_bdg domain-containing protein. (349 aa) |
| | FSBP | Uncharacterized protein. (966 aa) |
| | A0A4W2CA39 | PIEZO domain-containing protein. (449 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (809 aa) |
| | DBF4B | DBF4 zinc finger B. (569 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (279 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (351 aa) |
| | MCPH1 | Microcephalin 1. (872 aa) |
| | LIG1 | DNA ligase. (1303 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (836 aa) |
| | POLD1 | DNA polymerase. (1106 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (861 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1127 aa) |
| | ORC6 | Origin recognition complex subunit 6. (203 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (273 aa) |
| | RPA2 | RPA_C domain-containing protein. (270 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (389 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1253 aa) |
| | A0A4W2CYF2 | PWWP domain-containing protein. (159 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | ORC3 | Origin recognition complex subunit 3. (713 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1175 aa) |
| | A0A4W2D2X3 | Zinc-hook domain-containing protein. (1440 aa) |
| | CDC45 | Cell division cycle 45. (616 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa) |
| | POLK | DNA polymerase kappa. (911 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | RAD54L | RAD54 like. (749 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | DBF4 | DBF4 zinc finger. (674 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | MEIOB | Meiosis specific with OB-fold. (472 aa) |
| | RAD18 | RAD18 E3 ubiquitin protein ligase. (501 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1893 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (366 aa) |
| | MSH4 | MutS homolog 4. (934 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (859 aa) |
| | RMI1 | RecQ mediated genome instability 1. (624 aa) |
| | POLI | DNA polymerase iota. (760 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | POLH | DNA polymerase eta. (711 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (510 aa) |
| | RAD51D | RAD51 paralog D. (418 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1195 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (422 aa) |
| | DDX11 | DEAD/H-box helicase 11. (1012 aa) |
| | BLM | BLM RecQ like helicase. (1430 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1966 aa) |
| | RFC5 | Replication factor C subunit 5. (527 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (574 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1118 aa) |
| | FBH1 | F-box DNA helicase 1. (1045 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1754 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (916 aa) |
| | CHEK2 | Checkpoint kinase 2. (534 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa) |
| | ETAA1 | ETAA1 activator of ATR kinase. (899 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | POLD3 | Uncharacterized protein. (425 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | BRCA1 | BRCA1 DNA repair associated. (1941 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (906 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (120 aa) |
| | A0A4W2EGX9 | Uncharacterized protein. (502 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (600 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | PMS2 | MutL_C domain-containing protein. (461 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (708 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3133 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (773 aa) |
| | ERCC5 | ERCC excision repair 5, endonuclease. (1201 aa) |
| | CDC7 | Cell division cycle 7. (576 aa) |
| | MLH3 | MutL homolog 3. (1514 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (303 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (319 aa) |
| | CHD1L | Chromodomain helicase DNA binding protein 1 like. (897 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (180 aa) |
| | CLSPN | Claspin. (1338 aa) |
| | RFC1 | Replication factor C subunit 1. (1146 aa) |
| | HLTF | Helicase like transcription factor. (1009 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1521 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (915 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa) |
| | TIMELESS | Timeless circadian regulator. (1213 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1266 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (580 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (892 aa) |
| | ORC5 | Origin recognition complex subunit 5. (446 aa) |
| | TM4SF19 | Uncharacterized protein. (209 aa) |
| | RAD51B | RAD51 paralog B. (350 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (214 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (832 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa) |
| | RMI2 | RecQ mediated genome instability 2. (157 aa) |
| | EXO1 | Exonuclease 1. (835 aa) |
| | DMC1 | DNA meiotic recombinase 1; Belongs to the RecA family. (340 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (607 aa) |
