STRINGSTRING
FOXO1 FOXO1 EP300 EP300 FOXO3 FOXO3 AKT2 AKT2 SGK2 SGK2 FOXO6 FOXO6 SIRT1 SIRT1 FOXO4 FOXO4 A0A4W2DXS4 A0A4W2DXS4 SGK3 SGK3 AKT1 AKT1 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXO1Forkhead box O1. (604 aa)
EP300E1A binding protein p300. (2411 aa)
FOXO3Forkhead box O3. (617 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
SGK2Non-specific serine/threonine protein kinase. (585 aa)
FOXO6Forkhead box O6. (817 aa)
SIRT1Sirtuin 1. (734 aa)
FOXO4Forkhead box O4. (511 aa)
A0A4W2DXS4RING-type domain-containing protein. (131 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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