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FOXO1 | Forkhead box O1. (604 aa) | ||||
EP300 | E1A binding protein p300. (2411 aa) | ||||
FOXO3 | Forkhead box O3. (617 aa) | ||||
SIRT1 | Sirtuin 1. (734 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa) |