STRINGSTRING
TERF2 TERF2 TELO2 TELO2 PARP3 PARP3 BRCA2 BRCA2 INO80E INO80E RAD51C RAD51C WRN WRN TERF2IP TERF2IP ZNF365 ZNF365 MRE11 MRE11 A0A4W2C4K5 A0A4W2C4K5 YY1 YY1 CTC1 CTC1 WRAP53 WRAP53 NBN NBN FBXO4 FBXO4 ACD ACD TERT TERT PRKDC PRKDC XRCC1 XRCC1 ERCC1 ERCC1 TERF1 TERF1 INO80D INO80D XRCC5 XRCC5 INO80 INO80 SMC5 SMC5 PIF1 PIF1 PINX1 PINX1 RAD51 RAD51 DCLRE1C DCLRE1C A0A4W2D2X3 A0A4W2D2X3 DCLRE1B DCLRE1B ACTL6A ACTL6A PCNA PCNA ATR ATR SLX1A SLX1A ACTR8 ACTR8 ATM ATM RAD51D RAD51D DCLRE1A DCLRE1A STN1 STN1 RUVBL1 RUVBL1 BLM BLM XRCC6 XRCC6 SLX4 SLX4 NSMCE2 NSMCE2 A0A4W2E888 A0A4W2E888 CCNE1 CCNE1 LTO1 LTO1 ZNF827 ZNF827 SMC6 SMC6 HUS1 HUS1 TPRKB TPRKB CCNE2 CCNE2 TEP1 TEP1 TINF2 TINF2 NHP2 NHP2 RIF1 RIF1 NFRKB NFRKB UPF1 UPF1 ERCC4 ERCC4 PTGES3 PTGES3 ZBTB48 ZBTB48 NOP10 NOP10 RTEL1 RTEL1 APEX1 APEX1 MCRS1 MCRS1 DNA2 DNA2 POT1 POT1 UCHL5 UCHL5 RPA1 RPA1 MCUB-2 MCUB-2 TFPT TFPT RUVBL2 RUVBL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TERF2Telomeric repeat binding factor 2. (543 aa)
TELO2Telomere maintenance 2. (825 aa)
PARP3Poly [ADP-ribose] polymerase. (515 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
INO80EINO80 complex subunit E. (244 aa)
RAD51CRAD51 paralog C. (442 aa)
WRNWRN RecQ like helicase. (1409 aa)
TERF2IPTERF2 interacting protein. (399 aa)
ZNF365Zinc finger protein 365. (405 aa)
MRE11MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa)
A0A4W2C4K5RECA_2 domain-containing protein. (525 aa)
YY1YY1 transcription factor. (415 aa)
CTC1CST telomere replication complex component 1. (1210 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (809 aa)
FBXO4F-box protein 4. (387 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (523 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1125 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4122 aa)
XRCC1X-ray repair cross complementing 1. (692 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (351 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
INO80DINO80 complex subunit D. (1026 aa)
XRCC5X-ray repair cross complementing 5. (813 aa)
INO80INO80 complex ATPase subunit. (1584 aa)
SMC5SMC_N domain-containing protein. (1197 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (309 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
DCLRE1CDNA cross-link repair 1C. (710 aa)
A0A4W2D2X3Zinc-hook domain-containing protein. (1440 aa)
DCLRE1BDNA cross-link repair 1B. (542 aa)
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (366 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (832 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
RAD51DRAD51 paralog D. (418 aa)
DCLRE1ADNA cross-link repair 1A. (1045 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (391 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
BLMBLM RecQ like helicase. (1430 aa)
XRCC6X-ray repair cross complementing 6. (657 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1754 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (276 aa)
A0A4W2E888CS domain-containing protein. (167 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
LTO1LTO1 maturation factor of ABCE1. (137 aa)
ZNF827Zinc finger protein 827. (1352 aa)
SMC6Structural maintenance of chromosomes 6. (1098 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
TPRKBTP53RK binding protein; Belongs to the CGI121/TPRKB family. (175 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
TEP1Telomerase associated protein 1. (2656 aa)
TINF2TERF1 interacting nuclear factor 2. (463 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
RIF1Replication timing regulatory factor 1. (2465 aa)
NFRKBNuclear factor related to kappaB binding protein. (1291 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
PTGES3CS domain-containing protein. (160 aa)
ZBTB48Zinc finger and BTB domain containing 48. (688 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1266 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
MCRS1Microspherule protein 1. (462 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
POT1Protection of telomeres 1. (785 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (328 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
MCUB-2H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (210 aa)
TFPTTCF3 fusion partner. (251 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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