STRINGSTRING
IFITM5 IFITM5 RPL38 RPL38 SOX9 SOX9 BMPR1A BMPR1A CLEC3A CLEC3A MEF2C MEF2C TP53INP2 TP53INP2 HAND2 HAND2 NOG NOG IGF1 IGF1 IGFBP3 IGFBP3 ASPN ASPN KLF10 KLF10 MEF2D MEF2D WNT3A WNT3A HIF1A HIF1A SP3 SP3 SBDS SBDS PTN PTN SOST SOST PEX7 PEX7 IGF2 IGF2 SNAI2 SNAI2 A0A4W2GW60 A0A4W2GW60 SMPD3 SMPD3 DBN1 DBN1 SMO SMO BMP3 BMP3 ERCC2 ERCC2 MMP9 MMP9 SNX10 SNX10 NPPC NPPC MEN1 MEN1 MMP13 MMP13 SP7 SP7 SEMA4D SEMA4D BMP2 BMP2 COL1A2 COL1A2 NAB2 NAB2 IFT80 IFT80 FHL2 FHL2 AKT1 AKT1 SHOX2 SHOX2 FZD1 FZD1 SMAD5 SMAD5 RHOA RHOA CYP27B1 CYP27B1 AMELX AMELX FGR FGR ATP6V1B1 ATP6V1B1 COL1A1 COL1A1 FGF9 FGF9 LOC113877969 LOC113877969 SATB2 SATB2 ANKH ANKH CYP27C1 CYP27C1 A0A4W2F2V6 A0A4W2F2V6 RUNX1 RUNX1 CBS CBS PPARGC1B PPARGC1B SLC26A2 SLC26A2 GLIS1 GLIS1 PTHLH PTHLH BGLAP BGLAP ADAR ADAR EPHA2 EPHA2 DLX5 DLX5 CALCR CALCR A0A4W2EVH5 A0A4W2EVH5 FSTL3 FSTL3 FIGNL1 FIGNL1 A0A4W2EU87 A0A4W2EU87 MYF5 MYF5 SHH SHH DMP1 DMP1 LOX LOX SMAD3 SMAD3 A0A4W2EST9 A0A4W2EST9 TGFB3 TGFB3 GDF10 GDF10 CLEC5A CLEC5A CASR CASR CCN1 CCN1 A0A4W2EMV3 A0A4W2EMV3 ATP6V0A4 ATP6V0A4 COL2A1 COL2A1 CCN2 CCN2 SIRT7 SIRT7 HOXA2 HOXA2 BMP4 BMP4 SLC24A3 SLC24A3 CTHRC1 CTHRC1 A0A4W2EEK5 A0A4W2EEK5 FBXL15 FBXL15 BMPR2 BMPR2 PKDCC PKDCC UCMA UCMA IMPAD1 IMPAD1 FGF2 FGF2 A0A4W2EBE5 A0A4W2EBE5 INPPL1 INPPL1 CHRDL2 CHRDL2 PTH1R PTH1R SNAI1 SNAI1 RASSF2 RASSF2 TWSG1 TWSG1 A0A4W2E7C9 A0A4W2E7C9 NF1 NF1 TNN TNN MAP2K6 MAP2K6 TMEM119 TMEM119 CCN4 CCN4 PAM16 PAM16 LEF1 LEF1 MSX2 MSX2 WWOX WWOX GPLD1 GPLD1 SFRP1 SFRP1 PLXNB1 PLXNB1 CLEC3B CLEC3B SMAD1 SMAD1 LRP5 LRP5 LIMD1 LIMD1 HSD17B4 HSD17B4 JUNB JUNB BMPR1B BMPR1B SPP1 SPP1 IBSP IBSP THBS3 THBS3 TWIST1 TWIST1 WWTR1 WWTR1 A0A4W2DGD3 A0A4W2DGD3 DHX36 DHX36 ALPL ALPL ZMPSTE24 ZMPSTE24 LOC113891642 LOC113891642 COMP COMP RUNX3 RUNX3 AHSG AHSG TAPT1 TAPT1 EXT2 EXT2 DCHS1 DCHS1 TMEM38B TMEM38B MMP14 MMP14 DHH DHH GDF2 GDF2 CER1 CER1 TBC1D31 TBC1D31 WNT10B WNT10B ENPP1 ENPP1 GLI3 GLI3 GLI1 GLI1 FGF18 FGF18 A0A4W2CR26 A0A4W2CR26 IHH IHH MYOC MYOC PTH PTH EXT1 EXT1 CYP24A1 CYP24A1 NPR2 NPR2 DUOX2 DUOX2 AXIN2 AXIN2 A0A4W2CJC7 A0A4W2CJC7 TGFB1 TGFB1 A0A4W2CIF5 A0A4W2CIF5 LGR4 LGR4 EIF2AK3 EIF2AK3 WNT11 WNT11 ASF1A ASF1A FAT4 FAT4 WNT3 WNT3 ADAMTS12 ADAMTS12 TCIRG1 TCIRG1 CSGALNACT1 CSGALNACT1 MMP2 MMP2 ALOX15 ALOX15 MMP16 MMP16 CBFB CBFB MN1 MN1 MESD MESD SCX SCX PHOSPHO1 PHOSPHO1 ATF4 ATF4 MAPK11 MAPK11 THRA THRA RUNX2 RUNX2 BCL2 BCL2 SBNO2 SBNO2 TNFRSF11A TNFRSF11A COL13A1 COL13A1 EBP EBP TNFSF11 TNFSF11 LTF LTF LTBP3 LTBP3 BMP6 BMP6 A0A4W2BQT6 A0A4W2BQT6 CTNNB1 CTNNB1 GIT1 GIT1 CCDC154 CCDC154 ACHE ACHE SOX8 SOX8 A0A4W2BKZ5 A0A4W2BKZ5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFITM5Interferon induced transmembrane protein 5. (134 aa)
RPL38Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
SOX9SRY-box transcription factor 9. (524 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CLEC3AC-type lectin domain family 3 member A. (197 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (224 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
IGF1Insulin like growth factor 1. (188 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
ASPNAsporin. (370 aa)
KLF10Kruppel like factor 10. (483 aa)
MEF2DMyocyte enhancer factor 2D. (514 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
SP3Sp3 transcription factor. (781 aa)
SBDSSBDS ribosome maturation factor. (250 aa)
PTNPleiotrophin. (198 aa)
SOSTSclerostin. (212 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
IGF2Insulin like growth factor 2. (235 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
A0A4W2GW60Histone domain-containing protein. (136 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
DBN1Drebrin 1. (726 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (800 aa)
MMP9Matrix metallopeptidase 9. (712 aa)
SNX10Sorting nexin 10. (200 aa)
NPPCNatriuretic peptide C. (193 aa)
MEN1Menin 1. (610 aa)
MMP13Matrix metallopeptidase 13. (471 aa)
SP7Sp7 transcription factor. (431 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
NAB2NGFI-A binding protein 2. (525 aa)
IFT80Intraflagellar transport 80. (781 aa)
FHL2Four and a half LIM domains 2. (279 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
SHOX2Short stature homeobox 2. (331 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (645 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
RHOARas homolog family member A. (193 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
AMELXAmelogenin X-linked. (206 aa)
FGRTyrosine-protein kinase. (527 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
COL1A1Collagen type I alpha 1 chain. (1584 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC113877969Histone H3; Belongs to the histone H3 family. (136 aa)
SATB2DNA-binding protein SATB. (733 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (492 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (537 aa)
A0A4W2F2V6Uncharacterized protein. (122 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (585 aa)
PPARGC1BPPARG coactivator 1 beta. (1049 aa)
SLC26A2Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (734 aa)
GLIS1GLIS family zinc finger 1. (796 aa)
PTHLHParathyroid hormone like hormone. (177 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (100 aa)
ADARAdenosine deaminase RNA specific. (1175 aa)
EPHA2EPH receptor A2. (1007 aa)
DLX5Distal-less homeobox 5. (289 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (548 aa)
A0A4W2EVH5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1130 aa)
FSTL3Follistatin like 3. (378 aa)
FIGNL1Fidgetin like 1; Belongs to the AAA ATPase family. (677 aa)
A0A4W2EU87Uncharacterized protein. (226 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
DMP1Dentin matrix acidic phosphoprotein 1. (512 aa)
LOXLysyl oxidase. (418 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
A0A4W2EST9Histone H3; Belongs to the histone H3 family. (136 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
GDF10Growth differentiation factor 10. (512 aa)
CLEC5AC-type lectin domain containing 5A. (185 aa)
CASRCalcium sensing receptor. (1085 aa)
CCN1Cellular communication network factor 1. (463 aa)
A0A4W2EMV3Histone domain-containing protein. (136 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
CCN2Cellular communication network factor 2. (464 aa)
SIRT7Sirtuin 7. (420 aa)
HOXA2Homeobox A2. (372 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SLC24A3Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (749 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
A0A4W2EEK5C-type lectin domain-containing protein. (934 aa)
FBXL15F-box and leucine rich repeat protein 15. (335 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (136 aa)
IMPAD1Inositol monophosphatase domain containing 1. (359 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
A0A4W2EBE5Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
CHRDL2Chordin like 2. (430 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (589 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
RASSF2Ras association domain family member 2. (334 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
A0A4W2E7C9TNF receptor-associated factor. (411 aa)
NF1Neurofibromin 1. (3024 aa)
TNNTenascin N. (1296 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TMEM119Transmembrane protein 119. (287 aa)
CCN4Cellular communication network factor 4. (368 aa)
PAM16Presequence translocase associated motor 16. (125 aa)
LEF1Lymphoid enhancer binding factor 1. (430 aa)
MSX2Msh homeobox 2. (267 aa)
WWOXWW domain containing oxidoreductase. (490 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (843 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
PLXNB1Plexin B1. (2155 aa)
CLEC3BC-type lectin domain family 3 member B. (203 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1629 aa)
LIMD1LIM domains containing 1. (674 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (779 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (526 aa)
SPP1Secreted phosphoprotein 1. (338 aa)
IBSPIntegrin binding sialoprotein. (310 aa)
THBS3Thrombospondin 3. (998 aa)
TWIST1Twist family bHLH transcription factor 1. (201 aa)
WWTR1WW domain containing transcription regulator 1. (412 aa)
A0A4W2DGD3Uncharacterized protein. (472 aa)
DHX36DEAH-box helicase 36. (1010 aa)
ALPLAlkaline phosphatase. (524 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
LOC113891642Histone domain-containing protein. (136 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (434 aa)
AHSGAlpha 2-HS glycoprotein. (371 aa)
TAPT1Transmembrane anterior posterior transformation 1. (761 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (751 aa)
DCHS1Dachsous cadherin-related 1. (3525 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (401 aa)
GDF2Growth differentiation factor 2. (431 aa)
CER1Cerberus 1, DAN family BMP antagonist. (273 aa)
TBC1D31TBC1 domain family member 31. (1064 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (433 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (940 aa)
GLI3GLI family zinc finger 3. (1587 aa)
GLI1GLI family zinc finger 1. (1109 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
A0A4W2CR26TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (412 aa)
MYOCMyocilin. (490 aa)
PTHParathyroid hormone. (147 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (561 aa)
NPR2Guanylate cyclase. (1041 aa)
DUOX2Dual oxidase 2. (1545 aa)
AXIN2Axin 2. (836 aa)
A0A4W2CJC7Histone H3; Belongs to the histone H3 family. (140 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
A0A4W2CIF5Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ASF1AAnti-silencing function 1A histone chaperone. (204 aa)
FAT4FAT atypical cadherin 4. (4982 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1607 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
CSGALNACT1Hexosyltransferase. (526 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
CBFBCore-binding factor subunit beta. (187 aa)
MN1MN1 proto-oncogene, transcriptional regulator. (1309 aa)
MESDMesoderm development LRP chaperone. (276 aa)
SCXScleraxis bHLH transcription factor. (202 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (334 aa)
ATF4Activating transcription factor 4. (348 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
THRAThyroid hormone receptor alpha. (520 aa)
RUNX2RUNX family transcription factor 2. (527 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
SBNO2Strawberry notch homolog 2. (1352 aa)
TNFRSF11ATNF receptor superfamily member 11a. (588 aa)
COL13A1Collagen type XIII alpha 1 chain. (751 aa)
EBPEXPERA domain-containing protein. (230 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
LTFLactotransferrin; Belongs to the transferrin family. (726 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1341 aa)
BMP6Bone morphogenetic protein 6. (525 aa)
A0A4W2BQT6SCY domain-containing protein. (170 aa)
CTNNB1Catenin beta 1. (774 aa)
GIT1GIT ArfGAP 1. (770 aa)
CCDC154Coiled-coil domain containing 154. (526 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (615 aa)
SOX8SRY-box transcription factor 8. (534 aa)
A0A4W2BKZ5Uncharacterized protein. (195 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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