STRINGSTRING
HAND2 HAND2 LOXL2 LOXL2 EDN1 EDN1 EGR3 EGR3 AQP1 AQP1 SEMA4G SEMA4G SEMA5B SEMA5B PHOX2B PHOX2B SEMA7A SEMA7A HIF1A HIF1A EDN2 EDN2 RAB13 RAB13 PKN2 PKN2 S100A2 S100A2 KANK2 KANK2 LTB4R2 LTB4R2 ERBB4 ERBB4 PTPN11 PTPN11 SMO SMO SEMA3C SEMA3C FAP FAP ITGB1 ITGB1 ARSI ARSI SEMA4B SEMA4B GREM1 GREM1 SCARB1 SCARB1 SLIT2 SLIT2 NR4A1 NR4A1 SEMA4D SEMA4D ZFAND5 ZFAND5 NRTN NRTN FGF8 FGF8 PAFAH1B1 PAFAH1B1 PPARD PPARD AKT1 AKT1 PRKX PRKX RHOA RHOA ISL1 ISL1 S100Z S100Z KITLG KITLG ARSB ARSB WASF2 WASF2 GDNF GDNF EDNRA EDNRA WNT5A WNT5A SEMA3A SEMA3A SEMA3E SEMA3E GIPC1 GIPC1 EPB41L5 EPB41L5 ANXA6 ANXA6 PKN1 PKN1 MYH9 MYH9 SEMA4A SEMA4A PIK3R3 PIK3R3 DPP4 DPP4 GBX2 GBX2 PIP5K1A PIP5K1A SEMA6A SEMA6A SHH SHH A0A4W2EQZ6 A0A4W2EQZ6 GIPC3 GIPC3 VSTM4 VSTM4 LRG1 LRG1 MMRN2 MMRN2 FSTL1 FSTL1 FERMT1 FERMT1 ANLN ANLN SEMA5A SEMA5A KRT16 KRT16 MIXL1 MIXL1 EDNRB EDNRB PKN3 PKN3 TMEM201 TMEM201 CYP1B1 CYP1B1 PLEC PLEC FGF2 FGF2 SOX17 SOX17 ADGRA2 ADGRA2 TESK1 TESK1 PML PML SEMA6D SEMA6D SNAI1 SNAI1 FN1 FN1 CORO1C CORO1C NRP1 NRP1 SEMA3G SEMA3G WDPCP WDPCP SEMA3D SEMA3D DAAM2 DAAM2 CDH5 CDH5 CLEC14A CLEC14A VEGFA VEGFA LGALS8 LGALS8 APELA APELA GPLD1 GPLD1 PROX1 PROX1 LAMTOR2 LAMTOR2 NANOS1 NANOS1 SEMA3F SEMA3F ACVR1 ACVR1 ROCK1 ROCK1 A0A4W2DSW5 A0A4W2DSW5 SEMA6C SEMA6C LRP5 LRP5 CORO1B CORO1B GPX1 GPX1 PAXIP1 PAXIP1 ALX1 ALX1 GIPC2 GIPC2 SEMA6B SEMA6B AMOTL2 AMOTL2 TBXT TBXT ARSJ ARSJ TWIST1 TWIST1 SEMA4C SEMA4C ROBO1 ROBO1 FAT2 FAT2 CDC42 CDC42 LOC113892965 LOC113892965 KIT KIT FUT8 FUT8 KDR KDR CXCL13 CXCL13 ITGA4 ITGA4 CCN3 CCN3 NOS3 NOS3 ITGB7 ITGB7 CER1 CER1 PHACTR4 PHACTR4 SOX18 SOX18 IRS2 IRS2 HTR2B HTR2B ABL1 ABL1 KANK1 KANK1 CRB2 CRB2 PLEKHG5 PLEKHG5 SEMA4F SEMA4F EFNB2 EFNB2 TGFBR1 TGFBR1 TNS1 TNS1 SRF SRF LPXN LPXN ILK ILK EFNB1 EFNB1 MEGF8 MEGF8 WNT11 WNT11 SGPL1 SGPL1 CCBE1 CCBE1 CD248 CD248 TPBG TPBG MESP1 MESP1 PXN PXN RADIL RADIL ITGB4 ITGB4 IQGAP1 IQGAP1 SLC9A3R1 SLC9A3R1 SOX10 SOX10 RET RET A0A4W2C190 A0A4W2C190 ARID5B ARID5B CDH13 CDH13 AMOTL1 AMOTL1 NODAL NODAL SEMA3B SEMA3B CORO1A CORO1A PLXND1 PLXND1 ADTRP ADTRP LGALS12 LGALS12 CLN3 CLN3 EPHB4 EPHB4 STARD13 STARD13 SOX8 SOX8 RIC8A RIC8A NRP2 NRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
LOXL2Lysyl oxidase like 2. (774 aa)
EDN1Endothelin 1. (202 aa)
EGR3Early growth response 3. (387 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
SEMA5BSemaphorin 5B. (1113 aa)
PHOX2BPaired like homeobox 2B. (315 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
EDN2Endothelin 2. (186 aa)
RAB13Uncharacterized protein. (203 aa)
PKN2Protein kinase N2. (981 aa)
S100A2Protein S100; Belongs to the S-100 family. (112 aa)
KANK2KN motif and ankyrin repeat domains 2. (858 aa)
LTB4R2Leukotriene B4 receptor 2. (358 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ARSIArylsulfatase family member I. (574 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (859 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (586 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
ZFAND5Zinc finger AN1-type containing 5. (257 aa)
NRTNNeurturin. (197 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (347 aa)
RHOARas homolog family member A. (193 aa)
ISL1ISL LIM homeobox 1. (349 aa)
S100ZProtein S100; Belongs to the S-100 family. (99 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (249 aa)
ARSBArylsulfatase B. (533 aa)
WASF2WASP family member 2. (493 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (763 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (726 aa)
ANXA6Annexin. (751 aa)
PKN1Protein kinase N1. (956 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (851 aa)
PIK3R3Uncharacterized protein. (461 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (747 aa)
GBX2Gastrulation brain homeobox 2. (349 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1046 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
A0A4W2EQZ6Uncharacterized protein. (832 aa)
GIPC3GIPC PDZ domain containing family member 3. (318 aa)
VSTM4V-set and transmembrane domain containing 4. (319 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (353 aa)
MMRN2Multimerin 2. (932 aa)
FSTL1Follistatin like 1. (495 aa)
FERMT1Fermitin family member 1. (711 aa)
ANLNAnillin actin binding protein. (1129 aa)
SEMA5ASemaphorin 5A. (1084 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (432 aa)
MIXL1Mix paired-like homeobox. (244 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
PKN3Protein kinase N3. (889 aa)
TMEM201Transmembrane protein 201. (463 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (539 aa)
PLECPlectin. (4671 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
SOX17SRY-box transcription factor 17. (410 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1343 aa)
TESK1Testis associated actin remodelling kinase 1. (630 aa)
PMLPromyelocytic leukemia. (871 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1073 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
FN1Fibronectin 1. (2601 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (493 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (770 aa)
WDPCPWD repeat containing planar cell polarity effector. (609 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (776 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1074 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
CLEC14AC-type lectin domain containing 14A. (475 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
LGALS8Galectin. (357 aa)
APELAUncharacterized protein. (54 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (843 aa)
PROX1Prospero homeobox 1. (738 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
NANOS1Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (289 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (793 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
A0A4W2DSW5Uncharacterized protein. (191 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (956 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1629 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (488 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (204 aa)
PAXIP1PAX interacting protein 1. (983 aa)
ALX1ALX homeobox 1. (326 aa)
GIPC2GIPC PDZ domain containing family member 2. (316 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (1019 aa)
AMOTL2Angiomotin like 2. (823 aa)
TBXTT-box transcription factor T. (435 aa)
ARSJArylsulfatase family member J. (599 aa)
TWIST1Twist family bHLH transcription factor 1. (201 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1119 aa)
ROBO1Roundabout guidance receptor 1. (1650 aa)
FAT2FAT atypical cadherin 2. (4336 aa)
CDC42Cell division cycle 42. (191 aa)
LOC113892965SCHIP-1 domain-containing protein. (554 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CXCL13C-X-C motif chemokine. (109 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1338 aa)
CCN3Cellular communication network factor 3. (355 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (873 aa)
CER1Cerberus 1, DAN family BMP antagonist. (273 aa)
PHACTR4Phosphatase and actin regulator. (712 aa)
SOX18SRY-box transcription factor 18. (389 aa)
IRS2Insulin receptor substrate 2. (1325 aa)
HTR2B5-hydroxytryptamine receptor 2B. (538 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
KANK1KN motif and ankyrin repeat domains 1. (1384 aa)
CRB2Crumbs cell polarity complex component 2. (1281 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1143 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (771 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (342 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
TNS1Tensin 1. (1919 aa)
SRFSerum response factor. (509 aa)
LPXNLeupaxin. (399 aa)
ILKIntegrin linked kinase. (452 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (377 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
CCBE1Collagen and calcium binding EGF domains 1. (408 aa)
CD248CD248 molecule. (776 aa)
TPBGTrophoblast glycoprotein. (420 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
PXNUncharacterized protein. (1066 aa)
RADILRap associating with DIL domain. (1485 aa)
ITGB4Integrin beta. (1804 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1710 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (368 aa)
SOX10SRY-box transcription factor 10. (469 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
A0A4W2C190Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (281 aa)
ARID5BAT-rich interaction domain 5B. (1181 aa)
CDH13Cadherin 13. (713 aa)
AMOTL1Angiomotin like 1. (1118 aa)
NODALNodal growth differentiation factor. (346 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (753 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
PLXND1Plexin D1. (1930 aa)
ADTRPAndrogen dependent TFPI regulating protein. (230 aa)
LGALS12Galectin. (275 aa)
CLN3Battenin. (460 aa)
EPHB4EPH receptor B4. (987 aa)
STARD13StAR related lipid transfer domain containing 13. (1123 aa)
SOX8SRY-box transcription factor 8. (534 aa)
RIC8ARIC8 guanine nucleotide exchange factor A. (536 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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