STRINGSTRING
HECTD1 HECTD1 PKD1 PKD1 GGNBP2 GGNBP2 NODAL NODAL ASCL2 ASCL2 LIF LIF PRDX3 PRDX3 SOX15 SOX15 GHRL GHRL FOSL1 FOSL1 HEY2 HEY2 PLCD3 PLCD3 A0A4W2CFT3 A0A4W2CFT3 A0A4W2CHD8 A0A4W2CHD8 CCDC134 CCDC134 MDFI MDFI CUL7 CUL7 EPAS1 EPAS1 GRB2 GRB2 A0A4W2CNA5 A0A4W2CNA5 STK3 STK3 BIRC6 BIRC6 MAPK1 MAPK1 HNF1A HNF1A BPTF BPTF CITED2 CITED2 PLG PLG LEP LEP CTSB CTSB A0A4W2D1H6 A0A4W2D1H6 FZD5 FZD5 A0A4W2D326 A0A4W2D326 MAP2K1 MAP2K1 ADA ADA GRHL2 GRHL2 ZFP36L1 ZFP36L1 GJB5 GJB5 GJB3 GJB3 A0A4W2DA65 A0A4W2DA65 DAZAP1 DAZAP1 BMP7 BMP7 PKD2 PKD2 PCDH12 PCDH12 MAP3K4 MAP3K4 A0A4W2DHT6 A0A4W2DHT6 HES1 HES1 HAND1 HAND1 ST14 ST14 JUNB JUNB SETD2 SETD2 PLK4 PLK4 MED1 MED1 DLX3 DLX3 VASH2 VASH2 STOX2 STOX2 APELA APELA FBXW8 FBXW8 LEF1 LEF1 GCM1 GCM1 HTRA1 HTRA1 ZFAT ZFAT SPINT2 SPINT2 A0A4W2E766 A0A4W2E766 SNAI1 SNAI1 VDR VDR BMPR2 BMPR2 SPINT1 SPINT1 TPPP3 TPPP3 TAF10 TAF10 NCOA1 NCOA1 CCN1 CCN1 ALKBH1 ALKBH1 RBM15 RBM15 CSF2 CSF2 E2F7 E2F7 NOTCH2 NOTCH2 ADAM19 ADAM19 HS6ST1 HS6ST1 CYP27C1 CYP27C1 EPOR EPOR LHX4 LHX4 LHX3 LHX3 HSD17B2 HSD17B2 ETV2 ETV2 WNT2 WNT2 CDX2 CDX2 CYP27B1 CYP27B1 ASH1L ASH1L AKT1 AKT1 RSPO3 RSPO3 PPARD PPARD STK4 STK4 GHSR GHSR DEDD DEDD DNMT3L DNMT3L CEBPB CEBPB NR2F2 NR2F2 RTCB RTCB EGLN1 EGLN1 PTGS2 PTGS2 IGF2 IGF2 A0A4W2GYG4 A0A4W2GYG4 TRIM28 TRIM28 PTN PTN ARNT ARNT SP3 SP3 PRDM1 PRDM1 HIF1A HIF1A CDKN1B CDKN1B LOC113877898 LOC113877898 A0A4W2HZH4 A0A4W2HZH4 E2F8 E2F8 VASH1 VASH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
GGNBP2Gametogenetin binding protein 2. (951 aa)
NODALNodal growth differentiation factor. (346 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
PRDX3Peroxiredoxin 3. (281 aa)
SOX15SRY-box transcription factor 15. (233 aa)
GHRLGhrelin and obestatin prepropeptide. (133 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
PLCD3Phosphoinositide phospholipase C. (815 aa)
A0A4W2CFT3Uncharacterized protein. (336 aa)
A0A4W2CHD8Uncharacterized protein. (243 aa)
CCDC134Coiled-coil domain containing 134. (229 aa)
MDFIMyoD family inhibitor. (247 aa)
CUL7Cullin 7; Belongs to the cullin family. (1701 aa)
EPAS1Endothelial PAS domain protein 1. (928 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
A0A4W2CNA5Uncharacterized protein. (589 aa)
STK3Serine/threonine kinase 3. (491 aa)
BIRC6Baculoviral IAP repeat containing 6. (4861 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
HNF1AHNF1 homeobox A. (633 aa)
BPTFBromodomain PHD finger transcription factor. (3194 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
PLGPlasminogen; Belongs to the peptidase S1 family. (849 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (354 aa)
A0A4W2D1H6Uncharacterized protein. (67 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
A0A4W2D326Uncharacterized protein. (165 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
ADAAdenosine deaminase. (391 aa)
GRHL2Grainyhead like transcription factor 2. (609 aa)
ZFP36L1ZFP36 ring finger protein like 1. (323 aa)
GJB5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (273 aa)
GJB3Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (399 aa)
A0A4W2DA65IF rod domain-containing protein; Belongs to the intermediate filament family. (267 aa)
DAZAP1DAZ associated protein 1. (406 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (1071 aa)
PCDH12Protocadherin 12. (1197 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1654 aa)
A0A4W2DHT6Uncharacterized protein. (351 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
HAND1Heart and neural crest derivatives expressed 1. (394 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2563 aa)
PLK4Polo like kinase 4. (968 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
DLX3Distal-less homeobox 3. (287 aa)
VASH2Vasohibin 2. (373 aa)
STOX2Storkhead box 2. (992 aa)
APELAUncharacterized protein. (54 aa)
FBXW8F-box and WD repeat domain containing 8. (599 aa)
LEF1Lymphoid enhancer binding factor 1. (430 aa)
GCM1Glial cells missing transcription factor 1. (433 aa)
HTRA1HtrA serine peptidase 1. (529 aa)
ZFATZinc finger and AT-hook domain containing. (1323 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (250 aa)
A0A4W2E766Uncharacterized protein. (73 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
VDRVitamin D receptor. (425 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (513 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
NCOA1Nuclear receptor coactivator. (1440 aa)
CCN1Cellular communication network factor 1. (463 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
RBM15RNA binding motif protein 15. (962 aa)
CSF2Colony stimulating factor 2. (143 aa)
E2F7E2F transcription factor 7. (912 aa)
NOTCH2Notch receptor 2. (2471 aa)
ADAM19ADAM metallopeptidase domain 19. (906 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (537 aa)
EPORErythropoietin receptor. (539 aa)
LHX4LIM homeobox 4. (390 aa)
LHX3LIM homeobox 3. (403 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (388 aa)
ETV2ETS variant 2. (331 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CDX2Caudal type homeobox 2. (306 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
ASH1LASH1 like histone lysine methyltransferase. (2905 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
RSPO3R-spondin 3. (273 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
STK4Serine/threonine kinase 4. (487 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
DEDDDeath effector domain containing. (318 aa)
DNMT3LPHD-type domain-containing protein. (386 aa)
CEBPBCCAAT/enhancer-binding protein. (348 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
RTCBRNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. (505 aa)
EGLN1Uncharacterized protein. (420 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
IGF2Insulin like growth factor 2. (235 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
TRIM28Tripartite motif containing 28. (838 aa)
PTNPleiotrophin. (198 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (940 aa)
SP3Sp3 transcription factor. (781 aa)
PRDM1PR/SET domain 1. (842 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
LOC113877898Uncharacterized protein. (351 aa)
A0A4W2HZH4Uncharacterized protein. (165 aa)
E2F8E2F transcription factor 8. (868 aa)
VASH1Vasohibin 1. (363 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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