STRINGSTRING
HDAC1 HDAC1 A0A4W2EHH7 A0A4W2EHH7 A0A4W2EHQ1 A0A4W2EHQ1 TP53BP2 TP53BP2 BRD7 BRD7 SMARCB1 SMARCB1 TEP1 TEP1 CHD8 CHD8 MUL1 MUL1 A0A4W2EYN7 A0A4W2EYN7 NUAK1 NUAK1 PLK3 PLK3 MSX1 MSX1 TP73 TP73 NTRK3 NTRK3 USP7 USP7 RFFL RFFL RNF125 RNF125 TRIM29 TRIM29 RFWD3 RFWD3 POU4F2 POU4F2 EP300 EP300 RCHY1 RCHY1 ANKRD1 ANKRD1 TP63 TP63 EHMT1 EHMT1 SMARCA4 SMARCA4 PSME3 PSME3 BCL2L12 BCL2L12 HIF1A HIF1A SETD7 SETD7 TP53 TP53 STK11 STK11 DAXX DAXX CDKN2AIP CDKN2AIP EHMT2 EHMT2 PPP1R13B PPP1R13B MAPKAPK5 MAPKAPK5 TAF9 TAF9 KMT5A KMT5A MDM4 MDM4 NOP53 NOP53 USP10 USP10 MDM2 MDM2 GSK3B GSK3B TRIM24 TRIM24 ZNF385A ZNF385A HTT HTT RNF20 RNF20 CDK5 CDK5 CREBBP CREBBP PRMT5 PRMT5 AXIN1 AXIN1 PTTG1IP PTTG1IP SIRT1 SIRT1 KDM1A KDM1A BLM BLM DUSP26 DUSP26 TP53BP1 TP53BP1 A0A4W2E549 A0A4W2E549 TP53RK TP53RK RNF34 RNF34 TAF3 TAF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (513 aa)
A0A4W2EHH7Uncharacterized protein. (91 aa)
A0A4W2EHQ1Uncharacterized protein. (245 aa)
TP53BP2Tumor protein p53 binding protein 2. (1244 aa)
BRD7Bromodomain containing 7. (853 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (436 aa)
TEP1Telomerase associated protein 1. (2656 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (350 aa)
A0A4W2EYN7SEA domain-containing protein. (663 aa)
NUAK1NUAK family kinase 1. (662 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
MSX1Msh homeobox 1. (366 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (385 aa)
RNF125Ring finger protein 125. (234 aa)
TRIM29Tripartite motif containing 29. (617 aa)
RFWD3Ring finger and WD repeat domain 3. (790 aa)
POU4F2POU domain protein. (408 aa)
EP300E1A binding protein p300. (2411 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1293 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1639 aa)
PSME3Proteasome activator subunit 3. (231 aa)
BCL2L12BCL2 like 12. (252 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
DAXXDeath domain associated protein. (735 aa)
CDKN2AIPCDKN2A interacting protein. (746 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1389 aa)
PPP1R13BProtein phosphatase 1 regulatory subunit 13B. (1136 aa)
MAPKAPK5MAPK activated protein kinase 5. (470 aa)
TAF9TATA-box binding protein associated factor 9. (264 aa)
KMT5ALysine methyltransferase 5A. (352 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
NOP53NOP53 ribosome biogenesis factor. (534 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (800 aa)
MDM2MDM2 proto-oncogene. (689 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
TRIM24Tripartite motif containing 24. (1016 aa)
ZNF385AZinc finger protein 385A. (393 aa)
HTTHuntingtin. (3119 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CREBBPCREB binding protein. (2435 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa)
AXIN1Axin 1. (909 aa)
PTTG1IPPSI domain-containing protein. (282 aa)
SIRT1Sirtuin 1. (734 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (877 aa)
BLMBLM RecQ like helicase. (1430 aa)
DUSP26Dual specificity phosphatase 26; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (274 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
A0A4W2E549Uncharacterized protein. (76 aa)
TP53RKTP53 regulating kinase. (253 aa)
RNF34Ring finger protein 34. (442 aa)
TAF3TATA-box binding protein associated factor 3. (932 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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