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HDAC1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (513 aa) | ||||
A0A4W2EHH7 | Uncharacterized protein. (91 aa) | ||||
A0A4W2EHQ1 | Uncharacterized protein. (245 aa) | ||||
TP53BP2 | Tumor protein p53 binding protein 2. (1244 aa) | ||||
BRD7 | Bromodomain containing 7. (853 aa) | ||||
SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (436 aa) | ||||
TEP1 | Telomerase associated protein 1. (2656 aa) | ||||
CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa) | ||||
MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (350 aa) | ||||
A0A4W2EYN7 | SEA domain-containing protein. (663 aa) | ||||
NUAK1 | NUAK family kinase 1. (662 aa) | ||||
PLK3 | Serine/threonine-protein kinase PLK. (647 aa) | ||||
MSX1 | Msh homeobox 1. (366 aa) | ||||
TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa) | ||||
NTRK3 | Tyrosine-protein kinase receptor. (864 aa) | ||||
USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa) | ||||
RFFL | Ring finger and FYVE like domain containing E3 ubiquitin protein ligase. (385 aa) | ||||
RNF125 | Ring finger protein 125. (234 aa) | ||||
TRIM29 | Tripartite motif containing 29. (617 aa) | ||||
RFWD3 | Ring finger and WD repeat domain 3. (790 aa) | ||||
POU4F2 | POU domain protein. (408 aa) | ||||
EP300 | E1A binding protein p300. (2411 aa) | ||||
RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) | ||||
ANKRD1 | Ankyrin repeat domain 1. (319 aa) | ||||
TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) | ||||
EHMT1 | Euchromatic histone lysine methyltransferase 1. (1293 aa) | ||||
SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1639 aa) | ||||
PSME3 | Proteasome activator subunit 3. (231 aa) | ||||
BCL2L12 | BCL2 like 12. (252 aa) | ||||
HIF1A | Hypoxia inducible factor 1 subunit alpha. (842 aa) | ||||
SETD7 | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa) | ||||
STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) | ||||
DAXX | Death domain associated protein. (735 aa) | ||||
CDKN2AIP | CDKN2A interacting protein. (746 aa) | ||||
EHMT2 | Euchromatic histone lysine methyltransferase 2. (1389 aa) | ||||
PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1136 aa) | ||||
MAPKAPK5 | MAPK activated protein kinase 5. (470 aa) | ||||
TAF9 | TATA-box binding protein associated factor 9. (264 aa) | ||||
KMT5A | Lysine methyltransferase 5A. (352 aa) | ||||
MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa) | ||||
NOP53 | NOP53 ribosome biogenesis factor. (534 aa) | ||||
USP10 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (800 aa) | ||||
MDM2 | MDM2 proto-oncogene. (689 aa) | ||||
GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa) | ||||
TRIM24 | Tripartite motif containing 24. (1016 aa) | ||||
ZNF385A | Zinc finger protein 385A. (393 aa) | ||||
HTT | Huntingtin. (3119 aa) | ||||
RNF20 | E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa) | ||||
CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) | ||||
CREBBP | CREB binding protein. (2435 aa) | ||||
PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa) | ||||
AXIN1 | Axin 1. (909 aa) | ||||
PTTG1IP | PSI domain-containing protein. (282 aa) | ||||
SIRT1 | Sirtuin 1. (734 aa) | ||||
KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (877 aa) | ||||
BLM | BLM RecQ like helicase. (1430 aa) | ||||
DUSP26 | Dual specificity phosphatase 26; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (274 aa) | ||||
TP53BP1 | Tumor protein p53 binding protein 1. (1966 aa) | ||||
A0A4W2E549 | Uncharacterized protein. (76 aa) | ||||
TP53RK | TP53 regulating kinase. (253 aa) | ||||
RNF34 | Ring finger protein 34. (442 aa) | ||||
TAF3 | TATA-box binding protein associated factor 3. (932 aa) |