(56 nodes) Outflow tract morphogenesis network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	PLXND1	Plexin D1. (1930 aa)
	GATA6	GATA binding protein 6. (662 aa)
	FOXH1	Forkhead box H1. (359 aa)
	TBX3	T-box transcription factor 3. (748 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	NIPBL	Nipped-B protein. (2698 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	ILK	Integrin linked kinase. (452 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (302 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1151 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
	DHRS3	Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (322 aa)
	ATF2	Activating transcription factor 2. (447 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (329 aa)
	SMAD6	Mothers against decapentaplegic homolog. (529 aa)
	SIX1	SIX homeobox 1. (284 aa)
	CDC42	Cell division cycle 42. (191 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1459 aa)
	TWIST1	Twist family bHLH transcription factor 1. (201 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	NPY5R	Neuropeptide Y receptor Y5. (446 aa)
	SMAD4	Mothers against decapentaplegic homolog. (553 aa)
	LRP2	LDL receptor related protein 2. (4647 aa)
	TBX2	T-box transcription factor 2. (714 aa)
	NPY2R	Neuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	NOTCH1	Notch receptor 1. (2533 aa)
	ZFPM1	Zinc finger protein, FOG family member 1. (984 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (700 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
	ENG	Endoglin. (649 aa)
	SOX17	SRY-box transcription factor 17. (410 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	NPY1R	Neuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	ELN	Elastin. (760 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	TBX20	T-box transcription factor 20. (449 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	PARVA	Parvin alpha. (455 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (751 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (359 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (842 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	EDN1	Endothelin 1. (202 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (931 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF2	JUN	A0A4W2D7L6	A0A4W2I4Z9	Activating transcription factor 2.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.992
BMP4	BMPR1A	A0A4W2EH28	A0A4W2IPF0	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	BMPR2	A0A4W2EH28	A0A4W2EED7	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.990
BMP4	FGF8	A0A4W2EH28	A0A4W2FPR7	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.565
BMP4	GATA6	A0A4W2EH28	A0A4W2BSG3	Bone morphogenetic protein 4.	GATA binding protein 6.	0.570
BMP4	HAND2	A0A4W2EH28	A0A4W2IKY9	Bone morphogenetic protein 4.	Heart and neural crest derivatives expressed 2.	0.464
BMP4	ISL1	A0A4W2EH28	A0A4W2FJ42	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.480
BMP4	JAG1	A0A4W2EH28	A0A4W2FKH7	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.603
BMP4	NKX2-5	A0A4W2EH28	A0A4W2GA61	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.420
BMP4	NOG	A0A4W2EH28	A0A4W2IEW3	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.948
BMP4	SMAD4	A0A4W2EH28	A0A4W2DQT1	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.852
BMP4	SMAD6	A0A4W2EH28	A0A4W2D911	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.710
BMP4	SOX17	A0A4W2EH28	A0A4W2EC04	Bone morphogenetic protein 4.	SRY-box transcription factor 17.	0.744
BMP4	TBX3	A0A4W2EH28	A0A4W2C837	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.447
BMP4	TGFBR2	A0A4W2EH28	A0A4W2E9E9	Bone morphogenetic protein 4.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.524
BMP4	WNT11	A0A4W2EH28	A0A4W2CER5	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.409
BMP4	WNT5A	A0A4W2EH28	A0A4W2F8H8	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.518
BMPR1A	BMP4	A0A4W2IPF0	A0A4W2EH28	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.997
BMPR1A	BMPR2	A0A4W2IPF0	A0A4W2EED7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.983
BMPR1A	NOG	A0A4W2IPF0	A0A4W2IEW3	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.472

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