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UPF1 UPF1 RFC3 RFC3 CHTF18 CHTF18 NAV2 NAV2 WRNIP1 WRNIP1 MCM2 MCM2 BRIP1 BRIP1 C17orf64 C17orf64 WRN WRN MCM3 MCM3 MRE11 MRE11 RECQL5 RECQL5 CHD2 CHD2 FANCM FANCM IGHMBP2 IGHMBP2 SUB1 SUB1 CHD7 CHD7 MCM4 MCM4 XRCC5 XRCC5 DSCC1 DSCC1 PIF1 PIF1 CHD1 CHD1 RAD51 RAD51 A0A4W2D2X3 A0A4W2D2X3 RFC4 RFC4 A0A4W2DEF9 A0A4W2DEF9 SMARCAD1 SMARCAD1 DHX36 DHX36 RECQL RECQL MCM7 MCM7 DDX3X DDX3X G3BP1 G3BP1 ERCC3 ERCC3 A0A4W2DQT9 A0A4W2DQT9 RFC2 RFC2 RUVBL1 RUVBL1 DDX11 DDX11 BLM BLM XRCC6 XRCC6 FBH1 FBH1 CHD3 CHD3 MCM9 MCM9 DQX1 DQX1 ASCC3 ASCC3 CHD4 CHD4 CHD9 CHD9 CHD5 CHD5 POLQ POLQ CHD8 CHD8 CHD1L CHD1L HELQ HELQ MCM6 MCM6 CHD6 CHD6 RTEL1 RTEL1 DNA2 DNA2 ERCC2 ERCC2 GTF2F2 GTF2F2 MCM5 MCM5 TM4SF19 TM4SF19 HFM1 HFM1 HELB HELB MCM8 MCM8 SUPV3L1 SUPV3L1 RUVBL2 RUVBL2 DHX9 DHX9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
RFC3Replication factor C subunit 3. (356 aa)
CHTF18Chromosome transmission fidelity factor 18. (978 aa)
NAV2Neuron navigator 2. (2451 aa)
WRNIP1WRN helicase interacting protein 1. (638 aa)
MCM2DNA helicase; Belongs to the MCM family. (902 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1172 aa)
C17orf64Chromosome 17 open reading frame 64. (234 aa)
WRNWRN RecQ like helicase. (1409 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
MRE11MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (987 aa)
CHD2Uncharacterized protein. (1827 aa)
FANCMFA complementation group M. (2084 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (981 aa)
SUB1SUB1 regulator of transcription. (178 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2990 aa)
MCM4DNA helicase; Belongs to the MCM family. (836 aa)
XRCC5X-ray repair cross complementing 5. (813 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (389 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1710 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
A0A4W2D2X3Zinc-hook domain-containing protein. (1440 aa)
RFC4Replication factor C subunit 4. (364 aa)
A0A4W2DEF9General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (257 aa)
SMARCAD1Uncharacterized protein. (1029 aa)
DHX36DEAH-box helicase 36. (1010 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (780 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (645 aa)
G3BP1G3BP stress granule assembly factor 1. (465 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (780 aa)
A0A4W2DQT9TFIIF_beta domain-containing protein. (115 aa)
RFC2Replication factor C subunit 2. (352 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
DDX11DEAD/H-box helicase 11. (1012 aa)
BLMBLM RecQ like helicase. (1430 aa)
XRCC6X-ray repair cross complementing 6. (657 aa)
FBH1F-box DNA helicase 1. (1045 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2059 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (719 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2201 aa)
CHD4Uncharacterized protein. (1920 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2900 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1953 aa)
POLQDNA polymerase theta. (2585 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (897 aa)
HELQHelicase, POLQ like. (1092 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2721 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1266 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (800 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
MCM5DNA helicase; Belongs to the MCM family. (892 aa)
TM4SF19Uncharacterized protein. (209 aa)
HFM1Helicase for meiosis 1. (1437 aa)
HELBDNA helicase B. (1136 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (832 aa)
SUPV3L1Suv3 like RNA helicase. (787 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
DHX9DExH-box helicase 9. (1287 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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