STRINGSTRING
ALS2 ALS2 ARHGEF1 ARHGEF1 PLCE1 PLCE1 PREX2 PREX2 FGD2 FGD2 A0A4W2CHM1 A0A4W2CHM1 PLEKHG2 PLEKHG2 ARHGEF17 ARHGEF17 CCDC88A CCDC88A RAPGEFL1 RAPGEFL1 SBF1 SBF1 A0A4W2CE36 A0A4W2CE36 CCDC88C CCDC88C CYTH3 CYTH3 FGD5 FGD5 HPS4 HPS4 RANGRF RANGRF VPS9D1 VPS9D1 DENND1B DENND1B DENND10 DENND10 ARHGEF10 ARHGEF10 GBF1 GBF1 PSD PSD SPATA13 SPATA13 HPS1 HPS1 DOCK1 DOCK1 RASGEF1A RASGEF1A MON1B MON1B DENND6B DENND6B RASGRP2 RASGRP2 RIN1 RIN1 ALS2CL ALS2CL RABGEF1 RABGEF1 MON1A MON1A VAV1 VAV1 RAPGEF2 RAPGEF2 SMCR8 SMCR8 RAP1A RAP1A PREX1 PREX1 RAPGEF5 RAPGEF5 ARHGEF40 ARHGEF40 RASGEF1B RASGEF1B PLEKHG4 PLEKHG4 RHO RHO NUCB1 NUCB1 ANKRD27 ANKRD27 MYCBP2 MYCBP2 DIS3 DIS3 DOCK3 DOCK3 RINL RINL EIF2B1 EIF2B1 RABIF RABIF ARFGEF2 ARFGEF2 RCBTB1 RCBTB1 TRAPPC10 TRAPPC10 BORCS5 BORCS5 KALRN KALRN RGL3 RGL3 SH3BP5 SH3BP5 ARHGEF4 ARHGEF4 DOCK7 DOCK7 LAMTOR3 LAMTOR3 ARHGEF37 ARHGEF37 CYTH4 CYTH4 FGD4 FGD4 DENND5B DENND5B ITSN1 ITSN1 EIF2B3 EIF2B3 RCC1L RCC1L A0A4W2BKU6 A0A4W2BKU6 DENND6A DENND6A ARHGEF3 ARHGEF3 DENND4B DENND4B SMIM10L1 SMIM10L1 NGEF NGEF OBSCN OBSCN FARP2 FARP2 ARHGEF5 ARHGEF5 FGD3 FGD3 EIF2B5 EIF2B5 A0A4W2ES86 A0A4W2ES86 RAPGEF6 RAPGEF6 VAV3 VAV3 EIF2B2 EIF2B2 FGD6 FGD6 DENND1C DENND1C PCP2 PCP2 C9orf72 C9orf72 EIF2B4 EIF2B4 TIAM2 TIAM2 ARHGEF33 ARHGEF33 RANBP10 RANBP10 EEF1B2 EEF1B2 RIC8A RIC8A CYTH2 CYTH2 SOS1 SOS1 EPS8L1 EPS8L1 PLEKHG1 PLEKHG1 A0A4W2EHM6 A0A4W2EHM6 DOCK10 DOCK10 ECT2L ECT2L RGL1 RGL1 ARHGEF15 ARHGEF15 RGP1 RGP1 KNDC1 KNDC1 MADD MADD RASGRP1 RASGRP1 DOCK4 DOCK4 DOCK8 DOCK8 RGL2 RGL2 FARP1 FARP1 SOS2 SOS2 RASGRP4 RASGRP4 RALGPS1 RALGPS1 ARHGEF39 ARHGEF39 ARHGEF12 ARHGEF12 RASGRP3 RASGRP3 RALGPS2 RALGPS2 SBF2 SBF2 ELMO1 ELMO1 RCBTB2 RCBTB2 GDPGP1 GDPGP1 RASGRF1 RASGRF1 CYTH1 CYTH1 ABR ABR TRAPPC9 TRAPPC9 PSD3 PSD3 CLRN3 CLRN3 DNMBP DNMBP ARHGEF28 ARHGEF28 RIC8B RIC8B ADRB1 ADRB1 RIN3 RIN3 RALGDS RALGDS TIAM1 TIAM1 LAMTOR2 LAMTOR2 ARHGEF2 ARHGEF2 VAV2 VAV2 DENND3 DENND3 ARHGEF10L ARHGEF10L A0A4W2DVE6 A0A4W2DVE6 IQSEC1 IQSEC1 RAB3IL1 RAB3IL1 DOCK5 DOCK5 FBXO8 FBXO8 A0A4W2DPV9 A0A4W2DPV9 LOC113887367 LOC113887367 MCF2L2 MCF2L2 RASGRF2 RASGRF2 FNIP1 FNIP1 A0A4W2DN12 A0A4W2DN12 DENND2D DENND2D EPS8L2 EPS8L2 LAMTOR4 LAMTOR4 DOCK6 DOCK6 ARHGEF19 ARHGEF19 PSD2 PSD2 ARHGEF18 ARHGEF18 THG1L THG1L ARHGEF38 ARHGEF38 RAB3GAP1 RAB3GAP1 RAP1GDS1 RAP1GDS1 ARHGEF11 ARHGEF11 ARFGEF3 ARFGEF3 DENND1A DENND1A DOCK9 DOCK9 WDR41 WDR41 ECT2 ECT2 ARHGEF7 ARHGEF7 DENND2C DENND2C RAPGEF1 RAPGEF1 RASGEF1C RASGEF1C C12orf74 C12orf74 RAPGEF4 RAPGEF4 LAMTOR5 LAMTOR5 SH3BP5L SH3BP5L NET1 NET1 DENND4A DENND4A PLEKHG3 PLEKHG3 DENND5A DENND5A DENND2A DENND2A KIAA1755 KIAA1755 RAPGEF3 RAPGEF3 DENND11 DENND11 SH2D3A SH2D3A BCAR3 BCAR3 RCC1 RCC1 PREB PREB GAPVD1 GAPVD1 DENND4C DENND4C A0A4W2CVW9 A0A4W2CVW9 SH2D3C SH2D3C RIC1 RIC1 RAB3GAP2 RAB3GAP2 MCF2L MCF2L ARHGEF25 ARHGEF25 RAB3IP RAB3IP DOCK2 DOCK2 A0A4W2CS63 A0A4W2CS63 PLEKHG5 PLEKHG5 AKAP13 AKAP13 CCZ1 CCZ1 ARHGEF16 ARHGEF16 BCR BCR RIN2 RIN2 TRAPPC1 TRAPPC1 PLEKHG6 PLEKHG6 ST5 ST5 IQSEC3 IQSEC3 ARFGEF1 ARFGEF1 EEF1D EEF1D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1656 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (968 aa)
PLCE1Phosphoinositide phospholipase C. (1572 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1605 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (656 aa)
A0A4W2CHM1Uncharacterized protein. (1509 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1394 aa)
ARHGEF17Rho guanine nucleotide exchange factor 17. (2061 aa)
CCDC88ACoiled-coil domain containing 88A. (1842 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (675 aa)
SBF1SET binding factor 1. (1897 aa)
A0A4W2CE36Uncharacterized protein. (1403 aa)
CCDC88CCoiled-coil domain containing 88C. (2020 aa)
CYTH3Cytohesin 3. (418 aa)
FGD5FYVE, RhoGEF and PH domain containing 5. (1517 aa)
HPS4HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (681 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
VPS9D1VPS9 domain containing 1. (737 aa)
DENND1BDENN domain containing 1B. (773 aa)
DENND10DENN domain containing 10. (357 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1366 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1890 aa)
PSDPleckstrin and Sec7 domain containing. (1026 aa)
SPATA13Uncharacterized protein. (1260 aa)
HPS1HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (719 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1888 aa)
RASGEF1ARasGEF domain family member 1A. (499 aa)
MON1BMON1 homolog B, secretory trafficking associated. (548 aa)
DENND6BDENN domain containing 6B. (705 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
RIN1Ras and Rab interactor 1. (790 aa)
ALS2CLALS2 C-terminal like. (972 aa)
RABGEF1Uncharacterized protein. (783 aa)
MON1AMON1 homolog A, secretory trafficking associated. (559 aa)
VAV1Vav guanine nucleotide exchange factor 1. (872 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1689 aa)
SMCR8SMCR8-C9orf72 complex subunit. (938 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1653 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (889 aa)
ARHGEF40Rho guanine nucleotide exchange factor 40. (1520 aa)
RASGEF1BRasGEF domain family member 1B. (548 aa)
PLEKHG4Pleckstrin homology and RhoGEF domain containing G4. (1196 aa)
RHORhodopsin. (348 aa)
NUCB1Nucleobindin 1. (457 aa)
ANKRD27Ankyrin repeat domain 27. (1048 aa)
MYCBP2MYC binding protein 2. (4640 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2025 aa)
RINLRas and Rab interactor like. (562 aa)
EIF2B1Eukaryotic translation initiation factor 2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (305 aa)
RABIFRAB interacting factor. (123 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1779 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
TRAPPC10Foie-gras_1 domain-containing protein. (1259 aa)
BORCS5BLOC-1 related complex subunit 5. (196 aa)
KALRNKalirin RhoGEF kinase. (2987 aa)
RGL3Ral guanine nucleotide dissociation stimulator like 3. (698 aa)
SH3BP5SH3 domain binding protein 5. (449 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (688 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2147 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (722 aa)
CYTH4Cytohesin 4. (394 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (955 aa)
DENND5BDENN domain containing 5B. (1362 aa)
ITSN1Intersectin 1. (1721 aa)
EIF2B3Eukaryotic translation initiation factor 2B subunit gamma. (452 aa)
RCC1LRCC1 like. (527 aa)
A0A4W2BKU6Uncharacterized protein. (91 aa)
DENND6ADENN domain containing 6A. (608 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (558 aa)
DENND4BDENN domain containing 4B. (1501 aa)
SMIM10L1Small integral membrane protein 10 like 1. (68 aa)
NGEFNeuronal guanine nucleotide exchange factor. (667 aa)
OBSCNObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (7387 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1039 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1655 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (741 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (728 aa)
A0A4W2ES86Uncharacterized protein. (187 aa)
RAPGEF6Uncharacterized protein. (1612 aa)
VAV3Vav guanine nucleotide exchange factor 3. (977 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
FGD6FYVE, RhoGEF and PH domain containing 6. (1432 aa)
DENND1CDENN domain containing 1C. (876 aa)
PCP2Purkinje cell protein 2. (134 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (545 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1568 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (866 aa)
RANBP10RAN binding protein 10. (637 aa)
EEF1B2Uncharacterized protein; Belongs to the EF-1-beta/EF-1-delta family. (225 aa)
RIC8ARIC8 guanine nucleotide exchange factor A. (536 aa)
CYTH2Uncharacterized protein. (400 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
EPS8L1EPS8 like 1. (784 aa)
PLEKHG1Pleckstrin homology and RhoGEF domain containing G1. (1380 aa)
A0A4W2EHM6Uncharacterized protein. (68 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2199 aa)
ECT2LEpithelial cell transforming 2 like. (959 aa)
RGL1Ral guanine nucleotide dissociation stimulator like 1. (803 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (847 aa)
RGP1RGP1 homolog, RAB6A GEF complex partner 1. (394 aa)
KNDC1Kinase non-catalytic C-lobe domain containing 1. (1630 aa)
MADDMAP kinase activating death domain. (1646 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (1973 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2110 aa)
RGL2Ral guanine nucleotide dissociation stimulator like 2. (779 aa)
FARP1FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1046 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
RASGRP4RAS guanyl releasing protein 4. (673 aa)
RALGPS1Ral GEF with PH domain and SH3 binding motif 1. (585 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (335 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
RASGRP3RAS guanyl releasing protein 3. (692 aa)
RALGPS2Ral GEF with PH domain and SH3 binding motif 2. (583 aa)
SBF2SET binding factor 2. (1906 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (554 aa)
GDPGP1Uncharacterized protein. (385 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1269 aa)
CYTH1Cytohesin 1. (455 aa)
ABRABR activator of RhoGEF and GTPase. (1349 aa)
TRAPPC9Trafficking protein particle complex 9. (1148 aa)
PSD3Pleckstrin and Sec7 domain containing 3. (1253 aa)
CLRN3Clarin 3. (227 aa)
DNMBPDynamin binding protein. (1579 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1737 aa)
RIC8BRIC8 guanine nucleotide exchange factor B. (560 aa)
ADRB1Adrenoceptor beta 1. (514 aa)
RIN3Ras and Rab interactor 3. (1011 aa)
RALGDSUncharacterized protein. (1077 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1223 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
DENND3DENN domain containing 3. (1355 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1120 aa)
A0A4W2DVE6Uncharacterized protein. (870 aa)
IQSEC1IQ motif and Sec7 domain 1. (1243 aa)
RAB3IL1Sec2p domain-containing protein. (674 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1864 aa)
FBXO8F-box protein 8. (319 aa)
A0A4W2DPV9Uncharacterized protein. (91 aa)
LOC113887367Uncharacterized protein. (78 aa)
MCF2L2MCF.2 cell line derived transforming sequence-like 2. (1089 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1240 aa)
FNIP1Folliculin interacting protein 1. (1163 aa)
A0A4W2DN12Uncharacterized protein. (79 aa)
DENND2DDENN domain containing 2D. (478 aa)
EPS8L2EPS8 like 2. (713 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (104 aa)
DOCK6Dedicator of cytokinesis 6; Belongs to the DOCK family. (2047 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19. (807 aa)
PSD2Pleckstrin and Sec7 domain containing 2. (781 aa)
ARHGEF18Uncharacterized protein. (1345 aa)
THG1LtRNA-histidine guanylyltransferase 1 like. (368 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38. (778 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (991 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1. (608 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1590 aa)
ARFGEF3ARFGEF family member 3. (2176 aa)
DENND1ADENN domain containing 1A. (1049 aa)
DOCK9Dedicator of cytokinesis 9; Belongs to the DOCK family. (2170 aa)
WDR41WD repeat domain 41. (459 aa)
ECT2Epithelial cell transforming 2. (944 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
DENND2CDENN domain containing 2C. (936 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
RASGEF1CRasGEF domain family member 1C. (518 aa)
C12orf74Chromosome 12 open reading frame 74. (559 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
SH3BP5LSH3 binding domain protein 5 like. (385 aa)
NET1Neuroepithelial cell transforming 1. (590 aa)
DENND4ADENN domain containing 4A. (1906 aa)
PLEKHG3Pleckstrin homology and RhoGEF domain containing G3. (1208 aa)
DENND5ADENN domain containing 5A. (1279 aa)
DENND2ADENN domain containing 2A. (1162 aa)
KIAA1755KIAA1755. (1193 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
DENND11DENN domain containing 11. (565 aa)
SH2D3ASH2 domain containing 3A. (575 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (826 aa)
RCC1Regulator of chromosome condensation 1. (458 aa)
PREBProlactin regulatory element binding. (418 aa)
GAPVD1GTPase activating protein and VPS9 domains 1. (1461 aa)
DENND4CDENN domain containing 4C. (1964 aa)
A0A4W2CVW9Uncharacterized protein. (172 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
RIC1RIC1 homolog, RAB6A GEF complex partner 1. (1444 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1401 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (982 aa)
ARHGEF25Uncharacterized protein. (625 aa)
RAB3IPSec2p domain-containing protein. (460 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
A0A4W2CS63Uncharacterized protein. (120 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1143 aa)
AKAP13A-kinase anchoring protein 13. (2887 aa)
CCZ1Uncharacterized protein. (534 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (708 aa)
BCRBCR activator of RhoGEF and GTPase. (1283 aa)
RIN2Ras and Rab interactor 2. (909 aa)
TRAPPC1Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (145 aa)
PLEKHG6Pleckstrin homology and RhoGEF domain containing G6. (791 aa)
ST5Suppression of tumorigenicity 5. (1137 aa)
IQSEC3IQ motif and Sec7 domain 3. (1304 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1849 aa)
EEF1DUncharacterized protein; Belongs to the EF-1-beta/EF-1-delta family. (890 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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