STRINGSTRING
SCN9A SCN9A CACNA1D CACNA1D SCN11A SCN11A CACNA2D1 CACNA2D1 TRPM5 TRPM5 TRPC4 TRPC4 CACNG2 CACNG2 CACNA2D3 CACNA2D3 MCOLN1 MCOLN1 TRPM2 TRPM2 CACNA1A CACNA1A CACHD1 CACHD1 TRPM8 TRPM8 PKD2 PKD2 ITPR2 ITPR2 PKD2L2 PKD2L2 CATSPER3 CATSPER3 GOLM1 GOLM1 SLC24A1 SLC24A1 LRRIQ1 LRRIQ1 SLC24A5 SLC24A5 TRPV5 TRPV5 GRIN3A GRIN3A CACNB3 CACNB3 A0A4W2D0D8 A0A4W2D0D8 RYR3 RYR3 TMC1 TMC1 OPRM1 OPRM1 TMC2 TMC2 TRPV3 TRPV3 SLC24A4 SLC24A4 TRPM7 TRPM7 TRPV4 TRPV4 TRPA1 TRPA1 CACNG6 CACNG6 CACNB2 CACNB2 RYR2 RYR2 RYR1 RYR1 A0A4W2CFS7 A0A4W2CFS7 CACNG5 CACNG5 CACNG1 CACNG1 TPCN2 TPCN2 TRPV1 TRPV1 PKD1L3 PKD1L3 P2RX4 P2RX4 A0A4W2C7Y4 A0A4W2C7Y4 TPCN1 TPCN1 A0A4W2C7Q5 A0A4W2C7Q5 PANX1 PANX1 CACNA1C CACNA1C TRPC6 TRPC6 PKD2L1 PKD2L1 TRPC3 TRPC3 ITPR3 ITPR3 GRIN3B GRIN3B MCU MCU ORAI3 ORAI3 ORAI2 ORAI2 PKD1 PKD1 ITPR1 ITPR1 CACNA1F CACNA1F GRIN2A GRIN2A CNR1 CNR1 MCOLN3 MCOLN3 CACNA1B CACNA1B CACNG7 CACNG7 SCN8A SCN8A TRPM4 TRPM4 CACNG3 CACNG3 ANXA2 ANXA2 CACNG8 CACNG8 SEC61A1 SEC61A1 TRPV6 TRPV6 GRIN2B GRIN2B ITGAV ITGAV MCOLN2 MCOLN2 TMEM37 TMEM37 ANXA6 ANXA6 TRPC1 TRPC1 STIM2 STIM2 TRPC7 TRPC7 SCN1A SCN1A ANXA9 ANXA9 PSEN1 PSEN1 SLC24A2 SLC24A2 CATSPER4 CATSPER4 NCS1 NCS1 SLC24A3 SLC24A3 A0A4W2EE95 A0A4W2EE95 CALHM1 CALHM1 GRIN2D GRIN2D CACNA2D2 CACNA2D2 CACNG4 CACNG4 CATSPER1 CATSPER1 CACNA1E CACNA1E A0A4W2E4P6 A0A4W2E4P6 GRIN2C GRIN2C TRPV2 TRPV2 ORAI1 ORAI1 A0A4W2E0P3 A0A4W2E0P3 GPM6A GPM6A CACNB4 CACNB4 CACFD1 CACFD1 CACNA1S CACNA1S A0A4W2DWM2 A0A4W2DWM2 CACNA1I CACNA1I CACNA1G CACNA1G CACNB1 CACNB1 A0A4W2DTI8 A0A4W2DTI8 CACNA1H CACNA1H
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1987 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1782 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1106 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1174 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (984 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (300 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1091 aa)
MCOLN1Mucolipin 1. (653 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1499 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2502 aa)
CACHD1Cache domain containing 1. (1297 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1104 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (1071 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PKD2L2Polycystin 2 like 2, transient receptor potential cation channel. (624 aa)
CATSPER3Cation channel sperm associated 3. (400 aa)
GOLM1Golgi membrane protein 1. (405 aa)
SLC24A1Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1133 aa)
LRRIQ1Leucine rich repeats and IQ motif containing 1. (1699 aa)
SLC24A5Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (501 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (731 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1114 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (496 aa)
A0A4W2D0D8XRCC1_N domain-containing protein. (405 aa)
RYR3Ryanodine receptor 3. (4872 aa)
TMC1Transmembrane channel-like protein. (759 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (419 aa)
TMC2Transmembrane channel-like protein. (903 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (798 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (622 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1866 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (803 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
CACNG6Uncharacterized protein. (388 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (658 aa)
RYR2Ryanodine receptor 2. (4967 aa)
RYR1Ryanodine receptor 1. (5040 aa)
A0A4W2CFS7Uncharacterized protein. (2081 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (424 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (223 aa)
TPCN2Uncharacterized protein. (752 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (837 aa)
PKD1L3Polycystin 1 like 3, transient receptor potential channel interacting. (1695 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (394 aa)
A0A4W2C7Y4Uncharacterized protein. (199 aa)
TPCN1Two pore segment channel 1. (916 aa)
A0A4W2C7Q5Uncharacterized protein. (847 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (424 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (773 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (873 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1028 aa)
MCUMitochondrial calcium uniporter. (355 aa)
ORAI3ORAI calcium release-activated calcium modulator 3. (291 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (254 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1929 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
MCOLN3Mucolipin 3. (553 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2332 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1207 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ANXA2Annexin. (394 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (426 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (677 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (761 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1497 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
MCOLN2Mucolipin 2. (566 aa)
TMEM37Transmembrane protein 37. (203 aa)
ANXA6Annexin. (751 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
STIM2Stromal interaction molecule 2. (927 aa)
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
ANXA9Annexin. (345 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
SLC24A2Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (664 aa)
CATSPER4Cation channel sperm associated 4. (447 aa)
NCS1Neuronal calcium sensor 1. (370 aa)
SLC24A3Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (749 aa)
A0A4W2EE95Ion_trans domain-containing protein. (432 aa)
CALHM1Calcium homeostasis modulator 1. (344 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1333 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (321 aa)
CATSPER1Cation channel sperm associated 1. (690 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2447 aa)
A0A4W2E4P6VGCC_alpha2 domain-containing protein. (283 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (872 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (799 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (303 aa)
A0A4W2E0P3Uncharacterized protein. (2321 aa)
GPM6AGlycoprotein M6A. (317 aa)
CACNB4SH3 domain-containing protein. (502 aa)
CACFD1Calcium channel flower domain containing 1. (172 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
A0A4W2DWM2VWFA domain-containing protein. (988 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2208 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2380 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (643 aa)
A0A4W2DTI8Uncharacterized protein. (2321 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2259 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (24%) [HD]