STRINGSTRING
PCNA PCNA RFC3 RFC3 BRCA2 BRCA2 WRNIP1 WRNIP1 MCM2 MCM2 ZNF830 ZNF830 A0A4W2BUF7 A0A4W2BUF7 MUS81 MUS81 WRN WRN POLD4 POLD4 RFWD3 RFWD3 GINS4 GINS4 MCM3 MCM3 TRAIP TRAIP MRE11 MRE11 PRIMPOL PRIMPOL TONSL TONSL NOC3L NOC3L RECQL5 RECQL5 MCMBP MCMBP RPAIN RPAIN OOEP OOEP POLG2 POLG2 POLA2 POLA2 BAZ1A BAZ1A FANCM FANCM POLE POLE LIG1 LIG1 A0A4W2CIJ2 A0A4W2CIJ2 MCM4 MCM4 POLD1 POLD1 NRM NRM SMARCAL1 SMARCAL1 WDHD1 WDHD1 POLG POLG ORC6 ORC6 SAMHD1 SAMHD1 RTF2 RTF2 RAD51 RAD51 ORC3 ORC3 DDX23 DDX23 SSBP1 SSBP1 MGME1 MGME1 POLN POLN CDC45 CDC45 RFC4 RFC4 POLE2 POLE2 ZRANB3 ZRANB3 RECQL RECQL DONSON DONSON ORC1 ORC1 MCM7 MCM7 ATAD5 ATAD5 SRPK2 SRPK2 RFC2 RFC2 WDR18 WDR18 DDX50 DDX50 PRIM2 PRIM2 LIG3 LIG3 GMNN GMNN BLM BLM RFC5 RFC5 A0A4W2DZY8 A0A4W2DZY8 EME1 EME1 FBH1 FBH1 MCM10 MCM10 GINS3 GINS3 MCM9 MCM9 ETAA1 ETAA1 POLD3 POLD3 GINS1 GINS1 CCNE1 CCNE1 GEN1 GEN1 POLE4 POLE4 CDT1 CDT1 SIRT7 SIRT7 CCNE2 CCNE2 POLQ POLQ GMNC GMNC BOD1L1 BOD1L1 TIPIN TIPIN TOPBP1 TOPBP1 MCM6 MCM6 POLE3 POLE3 RRM2B RRM2B UPF1 UPF1 PURA PURA THOC1 THOC1 TIMELESS TIMELESS CDK9 CDK9 RTEL1 RTEL1 POLD2 POLD2 DNA2 DNA2 RRM1 RRM1 MCM5 MCM5 ORC5 ORC5 MMS22L MMS22L GINS2 GINS2 HELB HELB RPA1 RPA1 PRIM1 PRIM1 A0A4W2HXL3 A0A4W2HXL3 DDX21 DDX21 CENPS CENPS ZPR1 ZPR1 CDC6 CDC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
RFC3Replication factor C subunit 3. (356 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
WRNIP1WRN helicase interacting protein 1. (638 aa)
MCM2DNA helicase; Belongs to the MCM family. (902 aa)
ZNF830Zinc finger protein 830. (373 aa)
A0A4W2BUF7DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (531 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
WRNWRN RecQ like helicase. (1409 aa)
POLD4Uncharacterized protein. (315 aa)
RFWD3Ring finger and WD repeat domain 3. (790 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
TRAIPTRAF interacting protein. (472 aa)
MRE11MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa)
PRIMPOLPrimase and DNA directed polymerase. (555 aa)
TONSLTonsoku like, DNA repair protein. (1375 aa)
NOC3LNucleolar complex protein 3 homolog. (799 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (987 aa)
MCMBPMinichromosome maintenance complex binding protein. (642 aa)
RPAINRPA interacting protein. (295 aa)
OOEPOocyte expressed protein. (140 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (485 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1557 aa)
FANCMFA complementation group M. (2084 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
LIG1DNA ligase. (1303 aa)
A0A4W2CIJ2Uncharacterized protein. (164 aa)
MCM4DNA helicase; Belongs to the MCM family. (836 aa)
POLD1DNA polymerase. (1106 aa)
NRMNurim. (262 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (937 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1127 aa)
POLGDNA polymerase gamma, catalytic subunit. (1217 aa)
ORC6Origin recognition complex subunit 6. (203 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (608 aa)
RTF2Replication termination factor 2. (299 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ORC3Origin recognition complex subunit 3. (713 aa)
DDX23DEAD-box helicase 23. (909 aa)
SSBP1Single stranded DNA binding protein 1. (159 aa)
MGME1Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (342 aa)
POLNDNA polymerase nu. (791 aa)
CDC45Cell division cycle 45. (616 aa)
RFC4Replication factor C subunit 4. (364 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1096 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (780 aa)
DONSONDownstream neighbor of SON. (620 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
SRPK2SRSF protein kinase 2. (754 aa)
RFC2Replication factor C subunit 2. (352 aa)
WDR18WD repeat domain 18. (431 aa)
DDX50DExD-box helicase 50. (737 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (510 aa)
LIG3DNA ligase. (943 aa)
GMNNGeminin DNA replication inhibitor. (186 aa)
BLMBLM RecQ like helicase. (1430 aa)
RFC5Replication factor C subunit 5. (527 aa)
A0A4W2DZY8MOEP19 domain-containing protein. (598 aa)
EME1Essential meiotic structure-specific endonuclease 1. (574 aa)
FBH1F-box DNA helicase 1. (1045 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (916 aa)
GINS3GINS complex subunit 3. (216 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa)
ETAA1ETAA1 activator of ATR kinase. (899 aa)
POLD3Uncharacterized protein. (425 aa)
GINS1GINS complex subunit 1. (196 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (906 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (120 aa)
CDT1Chromatin licensing and DNA replication factor 1. (600 aa)
SIRT7Sirtuin 7. (420 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
POLQDNA polymerase theta. (2585 aa)
GMNCGeminin coiled-coil domain containing. (335 aa)
BOD1L1Biorientation of chromosomes in cell division 1 like 1. (2982 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (303 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
PURAPurine rich element binding protein A. (322 aa)
THOC1THO complex 1. (657 aa)
TIMELESSTimeless circadian regulator. (1213 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (494 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1266 aa)
POLD2DNA polymerase delta 2, accessory subunit. (580 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
MCM5DNA helicase; Belongs to the MCM family. (892 aa)
ORC5Origin recognition complex subunit 5. (446 aa)
MMS22LMMS22 like, DNA repair protein. (1243 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (214 aa)
HELBDNA helicase B. (1136 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
A0A4W2HXL3Uncharacterized protein. (76 aa)
DDX21DExD-box helicase 21. (784 aa)
CENPSCentromere protein S. (139 aa)
ZPR1ZPR1 zinc finger. (459 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (607 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (16%) [HD]