STRINGSTRING
PRIM2 PRIM2 GINS3 GINS3 CCNE1 CCNE1 CCNE2 CCNE2 GMNC GMNC TOPBP1 TOPBP1 MCM6 MCM6 MCM5 MCM5 CDC6 CDC6 PRIM1 PRIM1 ORC5 ORC5 MCM2 MCM2 MCM3 MCM3 NOC3L NOC3L POLA2 POLA2 MCM4 MCM4 ORC6 ORC6 ORC3 ORC3 CDC45 CDC45 ORC1 ORC1 MCM7 MCM7 MCM10 MCM10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (510 aa)
GINS3GINS complex subunit 3. (216 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
GMNCGeminin coiled-coil domain containing. (335 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
MCM5DNA helicase; Belongs to the MCM family. (892 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (607 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
ORC5Origin recognition complex subunit 5. (446 aa)
MCM2DNA helicase; Belongs to the MCM family. (902 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
NOC3LNucleolar complex protein 3 homolog. (799 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
MCM4DNA helicase; Belongs to the MCM family. (836 aa)
ORC6Origin recognition complex subunit 6. (203 aa)
ORC3Origin recognition complex subunit 3. (713 aa)
CDC45Cell division cycle 45. (616 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (916 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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