STRINGSTRING
ERCC2 ERCC2 USP7 USP7 OGG1 OGG1 BRCA2 BRCA2 GTF2H1 GTF2H1 XPC XPC BRIP1 BRIP1 KAT5 KAT5 GTF2H4 GTF2H4 GTF2H3 GTF2H3 POLE POLE ERCC1 ERCC1 POLD1 POLD1 A0A4W2CRB3 A0A4W2CRB3 XPA XPA RPA2 RPA2 A0A4W2CWS1 A0A4W2CWS1 ERCC6 ERCC6 UVSSA UVSSA RAD23B RAD23B POLK POLK ERCC3 ERCC3 A0A4W2DPA1 A0A4W2DPA1 NTHL1 NTHL1 SIRT1 SIRT1 A0A4W2DY12 A0A4W2DY12 POLL POLL SLX4 SLX4 COMMD1 COMMD1 POLD3 POLD3 FAN1 FAN1 A0A4W2EGX9 A0A4W2EGX9 HUS1 HUS1 POLR2I POLR2I ERCC5 ERCC5 A0A4W2EMF1 A0A4W2EMF1 RPA3 RPA3 A0A4W2F3C1 A0A4W2F3C1 MNAT1 MNAT1 ERCC4 ERCC4 XAB2 XAB2 RPA1 RPA1 ERCC8 ERCC8 FANCC FANCC CETN1 CETN1 DDB2 DDB2 LOC113878849 LOC113878849 TP53 TP53 RAD23A RAD23A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (800 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
OGG18-oxoguanine DNA glycosylase. (345 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (932 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1172 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
GTF2H3General transcription factor IIH subunit 3. (402 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (351 aa)
POLD1DNA polymerase. (1106 aa)
A0A4W2CRB3BRCT domain-containing protein. (169 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
RPA2RPA_C domain-containing protein. (270 aa)
A0A4W2CWS1RPA_C domain-containing protein. (253 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1544 aa)
UVSSAUV stimulated scaffold protein A. (691 aa)
RAD23BUncharacterized protein. (408 aa)
POLKDNA polymerase kappa. (911 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (780 aa)
A0A4W2DPA1Uncharacterized protein. (334 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (313 aa)
SIRT1Sirtuin 1. (734 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1754 aa)
COMMD1Copper metabolism domain containing 1. (196 aa)
POLD3Uncharacterized protein. (425 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1228 aa)
A0A4W2EGX9Uncharacterized protein. (502 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
POLR2IRNA polymerase II subunit I. (156 aa)
ERCC5ERCC excision repair 5, endonuclease. (1201 aa)
A0A4W2EMF1Uncharacterized protein. (286 aa)
RPA3Replication protein A3. (121 aa)
A0A4W2F3C1RPA_C domain-containing protein. (250 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
XAB2XPA binding protein 2. (855 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (568 aa)
CETN1Centrin 1. (172 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
LOC113878849General transcription factor IIH subunit. (405 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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