(81 nodes) Endoplasmic reticulum organization network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VCPIP1	Valosin containing protein interacting protein 1. (1223 aa)
	TOR1AIP2	Torsin 1A interacting protein 2. (469 aa)
	EMC6	ER membrane protein complex subunit 6. (110 aa)
	GET4	Guided entry of tail-anchored proteins factor 4. (422 aa)
	A0A4W2C770	MSP domain-containing protein. (258 aa)
	RNF112	Ring finger protein 112. (795 aa)
	PEX5	Peroxisomal biogenesis factor 5. (640 aa)
	SHTN1	Shootin 1. (628 aa)
	REEP5	Receptor expression-enhancing protein. (269 aa)
	BAG6	BCL2 associated athanogene 6. (1164 aa)
	PCNX2	Pecanex 2. (2128 aa)
	REEP3	Receptor expression-enhancing protein. (342 aa)
	SEC16A	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (2308 aa)
	UMOD	Uromodulin. (643 aa)
	LMAN1	Lectin, mannose binding 1. (568 aa)
	PCNX3	Pecanex 3. (2042 aa)
	RETREG2	Reticulophagy regulator family member 2. (541 aa)
	EMC3	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
	RETREG3	Reticulophagy regulator family member 3. (466 aa)
	MOSPD3	Motile sperm domain containing 3. (297 aa)
	SEC31A	SEC31 homolog A, COPII coat complex component. (1266 aa)
	LNPK	Lunapark, ER junction formation factor. (473 aa)
	LMAN2	Lectin, mannose binding 2. (429 aa)
	EMC2	ER membrane protein complex subunit 2. (409 aa)
	VAPB	VAMP associated protein B and C. (245 aa)
	EMC7	ER membrane protein complex subunit 7. (241 aa)
	LMAN2L	Lectin, mannose binding 2 like. (376 aa)
	GRAMD2A	GRAM domain containing 2A. (316 aa)
	ESYT2	Extended synaptotagmin 2. (898 aa)
	SPTSSB	Serine palmitoyltransferase small subunit B. (76 aa)
	TMEM33	Transmembrane protein 33. (350 aa)
	EMC1	ER membrane protein complex subunit 1. (1033 aa)
	TMEM38A	Transmembrane protein 38A. (422 aa)
	PCNX1	Pecanex 1. (2341 aa)
	TMEM38B	Transmembrane protein 38B. (291 aa)
	SGTA	Small glutamine rich tetratricopeptide repeat containing alpha. (363 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	RAB10	RAB10, member RAS oncogene family. (200 aa)
	POLR2M	RNA polymerase II subunit M. (370 aa)
	MIA3	MIA SH3 domain ER export factor 3. (1929 aa)
	CERT1	Ceramide transporter 1. (782 aa)
	CAMLG	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (292 aa)
	ASNA1	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (352 aa)
	EMC9	ER membrane protein complex subunit 9. (208 aa)
	STX18	Syntaxin 18. (440 aa)
	PCNX4	Pecanex 4. (1180 aa)
	A0A4W2DQW6	Uncharacterized protein. (144 aa)
	REEP4	Uncharacterized protein. (455 aa)
	ZFYVE27	Zinc finger FYVE-type containing 27. (484 aa)
	ATL2	Atlastin GTPase 2. (625 aa)
	GET1	Guided entry of tail-anchored proteins factor 1. (243 aa)
	EMC4	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (183 aa)
	ESYT1	Extended synaptotagmin 1. (1116 aa)
	EMC10	ER membrane protein complex subunit 10. (320 aa)
	REEP2	Receptor expression-enhancing protein. (320 aa)
	SEC61A1	SEC61 translocon alpha 1 subunit. (677 aa)
	C18H16orf74	Uncharacterized protein. (127 aa)
	WDR83OS	WD repeat domain 83 opposite strand. (106 aa)
	ATL1	Atlastin GTPase 1. (601 aa)
	CCDC47	Coiled-coil domain containing 47. (483 aa)
	LPCAT3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (485 aa)
	A0A4W2CN96	MSP domain-containing protein. (107 aa)
	A0A4W2CMS3	Translocating chain-associated membrane protein; Belongs to the TRAM family. (374 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	SEC31B	SEC31 homolog B, COPII coat complex component. (1127 aa)
	BNIP1	BCL2 interacting protein 1. (228 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (395 aa)
	ESYT3	Extended synaptotagmin 3. (870 aa)
	TRAM2	Translocating chain-associated membrane protein; Belongs to the TRAM family. (370 aa)
	REEP1	Receptor expression-enhancing protein. (346 aa)
	TOR1B	Torsin. (336 aa)
	RTN4	Reticulon. (1200 aa)
	SEC16B	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (1054 aa)
	EMC8	ER membrane protein complex subunit 8. (210 aa)
	RETREG1	Reticulophagy regulator 1. (615 aa)
	A0A4W2E2Q1	L-type lectin-like domain-containing protein. (183 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
	TMCC1	Transmembrane and coiled-coil domain family 1. (652 aa)
	RTN3	Reticulon. (1028 aa)
	ATL3	Atlastin GTPase 3. (541 aa)
	JAGN1	Jagunal homolog 1. (183 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2C770	A0A4W2CN96	A0A4W2C770	A0A4W2CN96	MSP domain-containing protein.	MSP domain-containing protein.	0.778
A0A4W2C770	CERT1	A0A4W2C770	A0A4W2DBD4	MSP domain-containing protein.	Ceramide transporter 1.	0.473
A0A4W2C770	GET4	A0A4W2C770	A0A4W2C8B2	MSP domain-containing protein.	Guided entry of tail-anchored proteins factor 4.	0.417
A0A4W2C770	LMAN1	A0A4W2C770	A0A4W2BVX3	MSP domain-containing protein.	Lectin, mannose binding 1.	0.410
A0A4W2C770	RTN3	A0A4W2C770	A0A4W2BRS5	MSP domain-containing protein.	Reticulon.	0.439
A0A4W2C770	ZFYVE27	A0A4W2C770	A0A4W2HF32	MSP domain-containing protein.	Zinc finger FYVE-type containing 27.	0.568
A0A4W2CMS3	CCDC47	A0A4W2CMS3	A0A4W2CTH2	Translocating chain-associated membrane protein; Belongs to the TRAM family.	Coiled-coil domain containing 47.	0.471
A0A4W2CN96	A0A4W2C770	A0A4W2CN96	A0A4W2C770	MSP domain-containing protein.	MSP domain-containing protein.	0.778
A0A4W2CN96	CERT1	A0A4W2CN96	A0A4W2DBD4	MSP domain-containing protein.	Ceramide transporter 1.	0.641
A0A4W2CN96	LMAN1	A0A4W2CN96	A0A4W2BVX3	MSP domain-containing protein.	Lectin, mannose binding 1.	0.407
A0A4W2CN96	RTN3	A0A4W2CN96	A0A4W2BRS5	MSP domain-containing protein.	Reticulon.	0.409
A0A4W2CN96	SGTA	A0A4W2CN96	A0A4W2D2B1	MSP domain-containing protein.	Small glutamine rich tetratricopeptide repeat containing alpha.	0.436
A0A4W2CN96	VAPB	A0A4W2CN96	A0A4W2EHE9	MSP domain-containing protein.	VAMP associated protein B and C.	0.778
A0A4W2CN96	ZFYVE27	A0A4W2CN96	A0A4W2HF32	MSP domain-containing protein.	Zinc finger FYVE-type containing 27.	0.656
A0A4W2E2Q1	EMC3	A0A4W2E2Q1	A0A4W2IHQ2	L-type lectin-like domain-containing protein.	ER membrane protein complex subunit 3; Belongs to the EMC3 family.	0.510
A0A4W2E2Q1	LMAN2	A0A4W2E2Q1	A0A4W2D603	L-type lectin-like domain-containing protein.	Lectin, mannose binding 2.	0.556
A0A4W2E2Q1	LMAN2L	A0A4W2E2Q1	A0A4W2EMU4	L-type lectin-like domain-containing protein.	Lectin, mannose binding 2 like.	0.544
A0A4W2E2Q1	SEC16A	A0A4W2E2Q1	A0A4W2BX55	L-type lectin-like domain-containing protein.	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.	0.508
A0A4W2E2Q1	SEC16B	A0A4W2E2Q1	A0A4W2E8M3	L-type lectin-like domain-containing protein.	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.	0.508
A0A4W2E2Q1	SEC31A	A0A4W2E2Q1	A0A4W2DB02	L-type lectin-like domain-containing protein.	SEC31 homolog A, COPII coat complex component.	0.577

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