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CNKSR1 CNKSR1 ARHGDIA ARHGDIA CTNNAL1 CTNNAL1 A0A4W2ES86 A0A4W2ES86 AGTR1 AGTR1 EPS8 EPS8 HACD3 HACD3 RHOA RHOA COL1A2 COL1A2 EPS8L3 EPS8L3 GNA13 GNA13 ARHGAP35 ARHGAP35 CDC42EP3 CDC42EP3 SYNJ2BP SYNJ2BP BCL6 BCL6 RACGAP1 RACGAP1 C15orf62 C15orf62 PLEKHG5 PLEKHG5 RIPOR1 RIPOR1 GNA12 GNA12 ADGRG1 ADGRG1 ROCK2 ROCK2 RHOV RHOV ARHGAP5 ARHGAP5 SHTN1 SHTN1 EPS8L1 EPS8L1 CDC42EP5 CDC42EP5 RHOG RHOG RHOU RHOU A0A4W2BZH9 A0A4W2BZH9 PHACTR4 PHACTR4 CDC42EP1 CDC42EP1 CDH13 CDH13 PDIA2 PDIA2 C12orf74 C12orf74 RHOJ RHOJ MYO9B MYO9B ARHGEF11 ARHGEF11 CDC42 CDC42 ARHGDIG ARHGDIG EPS8L2 EPS8L2 WAS WAS A0A4W2DVQ4 A0A4W2DVQ4 ROCK1 ROCK1 ITGA3 ITGA3 TAX1BP3 TAX1BP3 CDC42EP4 CDC42EP4 PDPN PDPN ARHGEF12 ARHGEF12 CELSR1 CELSR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNKSR1Connector enhancer of kinase suppressor of Ras 1. (718 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (204 aa)
CTNNAL1Catenin alpha like 1. (714 aa)
A0A4W2ES86Uncharacterized protein. (187 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (836 aa)
HACD3Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (389 aa)
RHOARas homolog family member A. (193 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
EPS8L3EPS8 like 3. (592 aa)
GNA13G protein subunit alpha 13. (377 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
CDC42EP3CDC42 effector protein 3. (254 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
BCL6BCL6 transcription repressor. (706 aa)
RACGAP1Rac GTPase activating protein 1. (651 aa)
C15orf62Chromosome 15 open reading frame 62. (176 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1143 aa)
RIPOR1RHO family interacting cell polarization regulator 1. (1330 aa)
GNA12G protein subunit alpha 12. (382 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (746 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1469 aa)
RHOVRas homolog family member V. (236 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
SHTN1Shootin 1. (628 aa)
EPS8L1EPS8 like 1. (784 aa)
CDC42EP5CDC42 effector protein 5. (153 aa)
RHOGRas homolog family member G. (191 aa)
RHOURas homolog family member U. (255 aa)
A0A4W2BZH9Uncharacterized protein. (727 aa)
PHACTR4Phosphatase and actin regulator. (712 aa)
CDC42EP1CDC42 effector protein 1. (361 aa)
CDH13Cadherin 13. (713 aa)
PDIA2Protein disulfide isomerase family A member 2. (788 aa)
C12orf74Chromosome 12 open reading frame 74. (559 aa)
RHOJRas homolog family member J. (236 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2150 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1590 aa)
CDC42Cell division cycle 42. (191 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (225 aa)
EPS8L2EPS8 like 2. (713 aa)
WASWASP actin nucleation promoting factor. (559 aa)
A0A4W2DVQ4Death domain-containing protein. (237 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1065 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
CDC42EP4CDC42 effector protein 4. (351 aa)
PDPNUncharacterized protein. (169 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3045 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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