STRINGSTRING
PTK2B PTK2B ARPC1B ARPC1B CCL26 CCL26 CCL24 CCL24 ESAM ESAM CORO1A CORO1A VILL VILL SPTBN2 SPTBN2 DBNL DBNL DEF6 DEF6 CSF3 CSF3 ARPC1A ARPC1A SSH2 SSH2 BAIAP2L2 BAIAP2L2 CARMIL1 CARMIL1 PDXP PDXP CDC42EP1 CDC42EP1 ARPC4 ARPC4 TMSB4X TMSB4X A0A4W2CAT2 A0A4W2CAT2 ALOX15 ALOX15 BAIAP2L1 BAIAP2L1 MKKS MKKS TMSB10 TMSB10 HIP1R HIP1R RICTOR RICTOR CAPG CAPG PLEKHG2 PLEKHG2 PRKCE PRKCE SPTBN4 SPTBN4 SPTBN1 SPTBN1 GRB2 GRB2 ARFGEF1 ARFGEF1 SVIL SVIL SWAP70 SWAP70 DSTN DSTN EVL EVL A0A4W2CQU2 A0A4W2CQU2 LOC113879851 LOC113879851 SPTAN1 SPTAN1 MTOR MTOR KANK1 KANK1 LATS1 LATS1 HCLS1 HCLS1 FAM49B FAM49B TWF1 TWF1 C15orf62 C15orf62 FER FER A0A4W2CZR5 A0A4W2CZR5 SNX9 SNX9 DLG1 DLG1 BBS4 BBS4 PLEKHH1 PLEKHH1 NCKAP1L NCKAP1L DMTN DMTN SPTB SPTB HAX1 HAX1 KIAA1211 KIAA1211 CAPZB CAPZB A0A4W2DHA5 A0A4W2DHA5 A0A4W2DHL6 A0A4W2DHL6 GSN GSN LMOD3 LMOD3 KANK4 KANK4 WAS WAS PRKCD PRKCD PIK3CA PIK3CA FHOD3 FHOD3 ACTN2 ACTN2 ARHGAP28 ARHGAP28 BAIAP2 BAIAP2 SPTA1 SPTA1 DAAM2 DAAM2 IQANK1 IQANK1 SH3BP1 SH3BP1 FCHSD2 FCHSD2 DLG2 DLG2 CDC42EP4 CDC42EP4 ADD2 ADD2 CFL2 CFL2 SSH3 SSH3 TMOD3 TMOD3 AVIL AVIL ARPC5L ARPC5L CAPZA2 CAPZA2 FLII FLII GBA2 GBA2 ARPC2 ARPC2 ARPC3 ARPC3 ARF6 ARF6 NPHS1 NPHS1 FMN1 FMN1 LIMA1 LIMA1 PLEK PLEK KANK3 KANK3 WDR1 WDR1 A0A4W2EVQ8 A0A4W2EVQ8 A0A4W2EVV4 A0A4W2EVV4 SCIN SCIN EPS8 EPS8 A0A4W2F1P2 A0A4W2F1P2 CYFIP2 CYFIP2 CYFIP1 CYFIP1 MLST8 MLST8 ELN ELN COTL1 COTL1 BAG4 BAG4 ABITRAM ABITRAM PIK3R2 PIK3R2 NCK2 NCK2 FCHSD1 FCHSD1 TMOD2 TMOD2 SLIT2 SLIT2 LMOD1 LMOD1 CCL11 CCL11 RDX RDX LOC113879884 LOC113879884 LMOD2 LMOD2 VASP VASP ARHGAP35 ARHGAP35 NCK1 NCK1 ARPC5 ARPC5 CDC42EP3 CDC42EP3 BRK1 BRK1 CAPZA3 CAPZA3 SSH1 SSH1 TMOD1 TMOD1 PFN2 PFN2 ADD1 ADD1 TWF2 TWF2 NAA80 NAA80 CAPZA1 CAPZA1 ADD3 ADD3 CCL21 CCL21 MYADM MYADM PLEKHH2 PLEKHH2 CTTN CTTN CDC42EP5 CDC42EP5 PFN3 PFN3 VIL1 VIL1 TMOD4 TMOD4 FAM49A FAM49A PFN1 PFN1 PFN4 PFN4 MTPN MTPN RASA1 RASA1 PYCARD PYCARD ARHGAP18 ARHGAP18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1008 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
CCL26C-C motif chemokine. (94 aa)
CCL24C-C motif chemokine ligand 24. (116 aa)
ESAMEndothelial cell adhesion molecule. (396 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
VILLVillin like. (856 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2531 aa)
DBNLDrebrin like. (503 aa)
DEF6DEF6 guanine nucleotide exchange factor. (701 aa)
CSF3Colony stimulating factor 3. (215 aa)
ARPC1AWD_REPEATS_REGION domain-containing protein. (430 aa)
SSH2Slingshot protein phosphatase 2. (1429 aa)
BAIAP2L2BAI1 associated protein 2 like 2. (528 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1426 aa)
PDXPPyridoxal phosphatase; Belongs to the HAD-like hydrolase superfamily. (296 aa)
CDC42EP1CDC42 effector protein 1. (361 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
A0A4W2CAT2MARVEL domain-containing protein. (335 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
BAIAP2L1BAI1 associated protein 2 like 1. (536 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
HIP1RHuntingtin interacting protein 1 related. (1066 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1789 aa)
CAPGCapping actin protein, gelsolin like. (412 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1394 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2615 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2350 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1849 aa)
SVILSupervillin. (2301 aa)
SWAP70Switching B cell complex subunit SWAP70. (585 aa)
DSTNDestrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (165 aa)
EVLEnah/Vasp-like. (455 aa)
A0A4W2CQU2Uncharacterized protein. (315 aa)
LOC113879851Uncharacterized protein. (303 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2498 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
KANK1KN motif and ankyrin repeat domains 1. (1384 aa)
LATS1Large tumor suppressor kinase 1. (1123 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (485 aa)
FAM49BFamily with sequence similarity 49 member B. (465 aa)
TWF1Twinfilin actin binding protein 1. (368 aa)
C15orf62Chromosome 15 open reading frame 62. (176 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
A0A4W2CZR5Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (406 aa)
SNX9Sorting nexin. (624 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1359 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
DMTNDematin actin binding protein. (467 aa)
SPTBSpectrin beta chain; Belongs to the spectrin family. (2331 aa)
HAX1HCLS1 associated protein X-1. (287 aa)
KIAA1211KIAA1211. (1391 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (306 aa)
A0A4W2DHA5Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (159 aa)
A0A4W2DHL6Uncharacterized protein. (165 aa)
GSNGelsolin. (846 aa)
LMOD3Leiomodin 3. (567 aa)
KANK4KN motif and ankyrin repeat domains 4. (1014 aa)
WASWASP actin nucleation promoting factor. (559 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FHOD3Formin homology 2 domain containing 3. (1612 aa)
ACTN2Actinin alpha 2. (894 aa)
ARHGAP28Rho GTPase activating protein 28. (755 aa)
BAIAP2BAI1 associated protein 2. (568 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2419 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1074 aa)
IQANK1IQ motif and ankyrin repeat containing 1. (591 aa)
SH3BP1Uncharacterized protein. (693 aa)
FCHSD2FCH and double SH3 domains 2. (764 aa)
DLG2Discs large MAGUK scaffold protein 2. (1009 aa)
CDC42EP4CDC42 effector protein 4. (351 aa)
ADD2Adducin 2. (724 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
SSH3Slingshot protein phosphatase 3. (649 aa)
TMOD3Tropomodulin 3. (352 aa)
AVILAdvillin. (816 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
CAPZA2F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
FLIIFLII actin remodeling protein. (1268 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (906 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (190 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1242 aa)
FMN1Formin 1. (1419 aa)
LIMA1LIM domain and actin binding 1. (761 aa)
PLEKPleckstrin. (348 aa)
KANK3KN motif and ankyrin repeat domains 3. (876 aa)
WDR1WD repeat domain 1. (606 aa)
A0A4W2EVQ8Uncharacterized protein; Belongs to the profilin family. (69 aa)
A0A4W2EVV4Profilin; Belongs to the profilin family. (87 aa)
SCINScinderin. (832 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (836 aa)
A0A4W2F1P2ANAPC4_WD40 domain-containing protein. (204 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
ELNElastin. (760 aa)
COTL1Coactosin like F-actin binding protein 1. (142 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
ABITRAMActin binding transcription modulator. (187 aa)
PIK3R2Uncharacterized protein. (724 aa)
NCK2Cytoplasmic protein. (376 aa)
FCHSD1FCH and double SH3 domains 1. (692 aa)
TMOD2Tropomodulin 2. (351 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
LMOD1Leiomodin 1. (578 aa)
CCL11C-C motif chemokine. (97 aa)
RDXRadixin. (624 aa)
LOC113879884Uncharacterized protein. (317 aa)
LMOD2Leiomodin 2. (585 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
NCK1Cytoplasmic protein. (377 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
CDC42EP3CDC42 effector protein 3. (254 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
SSH1Slingshot protein phosphatase 1. (988 aa)
TMOD1Tropomodulin 1. (359 aa)
PFN2Profilin; Belongs to the profilin family. (142 aa)
ADD1Adducin 1. (769 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
NAA80N(alpha)-acetyltransferase 80, NatH catalytic subunit. (309 aa)
CAPZA1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
ADD3Adducin 3. (706 aa)
CCL21C-C motif chemokine ligand 21. (133 aa)
MYADMMyeloid associated differentiation marker. (322 aa)
PLEKHH2Pleckstrin homology, MyTH4 and FERM domain containing H2. (1491 aa)
CTTNCortactin. (538 aa)
CDC42EP5CDC42 effector protein 5. (153 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
VIL1Villin 1. (827 aa)
TMOD4Tropomodulin 4. (379 aa)
FAM49AFamily with sequence similarity 49 member A. (323 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
MTPNMyotrophin. (118 aa)
RASA1RAS p21 protein activator 1. (1044 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ARHGAP18Rho GTPase activating protein 18. (665 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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