STRINGSTRING
PCGF5 PCGF5 RNF2 RNF2 RNF40 RNF40 DDB2 DDB2 WAC WAC KDM2B KDM2B RAG1 RAG1 ATXN7L3 ATXN7L3 PCGF1 PCGF1 LEO1 LEO1 DTX3L DTX3L RING1 RING1 DDB1 DDB1 RNF168 RNF168 UBE2E1 UBE2E1 PAF1 PAF1 CDC73 CDC73 PCGF3 PCGF3 A0A4W2EUZ6 A0A4W2EUZ6 RYBP RYBP TRIM37 TRIM37 RNF20 RNF20 UHRF1 UHRF1 CUL4B CUL4B PCGF6 PCGF6 CTR9 CTR9 COMMD3 COMMD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCGF5Polycomb group ring finger 5. (256 aa)
RNF2Ring finger protein 2. (336 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
WACWW domain containing adaptor with coiled-coil. (646 aa)
KDM2BLysine demethylase 2B. (1424 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
ATXN7L3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (354 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (668 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (739 aa)
RING1Ring finger protein 1. (407 aa)
DDB1Damage specific DNA binding protein 1. (1506 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (532 aa)
CDC73Cell division cycle 73. (531 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
A0A4W2EUZ6RING-type domain-containing protein. (58 aa)
RYBPRING1 and YY1 binding protein. (228 aa)
TRIM37Tripartite motif containing 37. (961 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (917 aa)
CUL4BCullin 4B; Belongs to the cullin family. (734 aa)
PCGF6Polycomb group ring finger 6. (351 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
COMMD3RING-type domain-containing protein. (469 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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