STRINGSTRING
ADAM17 ADAM17 ALOX12 ALOX12 AGT AGT ZNF580 ZNF580 NRP1 NRP1 VEGFA VEGFA GPLD1 GPLD1 PIK3CB PIK3CB PROX1 PROX1 SIRT1 SIRT1 ANXA3 ANXA3 PIK3CG PIK3CG HMOX1 HMOX1 FOXP1 FOXP1 PDPK1 PDPK1 PLPP3 PLPP3 FGF1 FGF1 ZC3H12A ZC3H12A RHOJ RHOJ KDR KDR FLT4 FLT4 NOS3 NOS3 FGFBP1 FGFBP1 SMOC2 SMOC2 ROCK2 ROCK2 TEK TEK GATA3 GATA3 NUS1 NUS1 SASH1 SASH1 A0A4W2CUB5 A0A4W2CUB5 ABL1 ABL1 FGF18 FGF18 PIK3CD PIK3CD A0A4W2CRW3 A0A4W2CRW3 RIN2 RIN2 A0A4W2CP79 A0A4W2CP79 ANGPT1 ANGPT1 A0A4W2CIL9 A0A4W2CIL9 TGFB1 TGFB1 PRKD2 PRKD2 A0A4W2CEF6 A0A4W2CEF6 CCBE1 CCBE1 GPI GPI FGFR1 FGFR1 ATOH8 ATOH8 P2RX4 P2RX4 LGMN LGMN WNT7A WNT7A PDGFB PDGFB BCAR1 BCAR1 ATP5F1A ATP5F1A HSPB1 HSPB1 HDAC7 HDAC7 CIB1 CIB1 HIF1A HIF1A RRAS RRAS ETS1 ETS1 PRKD1 PRKD1 PRKCA PRKCA EMC10 EMC10 AKT1 AKT1 WNT5A WNT5A SPARC SPARC PTK2B PTK2B SP1 SP1 ATP5F1B ATP5F1B THBS1 THBS1 ANGPT4 ANGPT4 BMP4 BMP4 JCAD JCAD MAP2K3 MAP2K3 BMPR2 BMPR2 MET MET ITGB1BP1 ITGB1BP1 STAT5A STAT5A FGF2 FGF2 AKT3 AKT3 ADGRA2 ADGRA2 CD40 CD40 PLK2 PLK2 AAMP AAMP MAP3K3 MAP3K3 FUT1 FUT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAM17ADAM metallopeptidase domain 17. (825 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (676 aa)
AGTAngiotensinogen; Belongs to the serpin family. (476 aa)
ZNF580Zinc finger protein 580. (172 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (843 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PROX1Prospero homeobox 1. (738 aa)
SIRT1Sirtuin 1. (734 aa)
ANXA3Annexin. (323 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1171 aa)
HMOX1Heme oxygenase 1. (302 aa)
FOXP1Fork-head domain-containing protein. (691 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (747 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (583 aa)
RHOJRas homolog family member J. (236 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
SMOC2SPARC related modular calcium binding 2. (655 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1469 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
GATA3GATA binding protein 3. (467 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
SASH1SAM and SH3 domain containing 1. (1236 aa)
A0A4W2CUB5Uncharacterized protein. (90 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
A0A4W2CRW3Annexin. (346 aa)
RIN2Ras and Rab interactor 2. (909 aa)
A0A4W2CP79Annexin. (335 aa)
ANGPT1Angiopoietin 1. (498 aa)
A0A4W2CIL9Uncharacterized protein. (423 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
A0A4W2CEF6Integrin beta; Belongs to the integrin beta chain family. (784 aa)
CCBE1Collagen and calcium binding EGF domains 1. (408 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (565 aa)
FGFR1Fibroblast growth factor receptor. (856 aa)
ATOH8Atonal bHLH transcription factor 8. (317 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (394 aa)
LGMNLegumain. (433 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (919 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (588 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (216 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1092 aa)
CIB1Calcium and integrin binding 1. (191 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
RRASRAS related. (218 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
EMC10ER membrane protein complex subunit 10. (320 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SPARCSecreted protein acidic and cysteine rich. (472 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1008 aa)
SP1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1209 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
THBS1Thrombospondin 1. (1170 aa)
ANGPT4Angiopoietin 4. (560 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
JCADJunctional cadherin 5 associated. (1305 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1343 aa)
CD40CD40 molecule. (280 aa)
PLK2Serine/threonine-protein kinase PLK. (864 aa)
AAMPAngio associated migratory cell protein. (435 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (416 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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