STRINGSTRING
LIMS1 LIMS1 DDR1 DDR1 LRRC45 LRRC45 GREM1 GREM1 AGR2 AGR2 ANGPT2 ANGPT2 PREX1 PREX1 LOC113879884 LOC113879884 EPHA3 EPHA3 RSU1 RSU1 EMILIN1 EMILIN1 CDH13 CDH13 PLEKHA2 PLEKHA2 ONECUT2 ONECUT2 BCL2 BCL2 DLC1 DLC1 PLAU PLAU A0A4W2BLC1 A0A4W2BLC1 A0A4W2BMR3 A0A4W2BMR3 A0A4W2BPH2 A0A4W2BPH2 VCL VCL NEDD9 NEDD9 CORO2A CORO2A JUP JUP S100A10 S100A10 PTPRA PTPRA PPM1F PPM1F ECM2 ECM2 TACSTD2 TACSTD2 RCC2 RCC2 PTK2B PTK2B MYF5 MYF5 CSF1 CSF1 EPHA1 EPHA1 EFNA5 EFNA5 BRAF BRAF CAMSAP3 CAMSAP3 CCN1 CCN1 FMN1 FMN1 THY1 THY1 CCL25 CCL25 CCDC80 CCDC80 UTRN UTRN FERMT1 FERMT1 AJAP1 AJAP1 APOD APOD ACER2 ACER2 PHLDB2 PHLDB2 ACVRL1 ACVRL1 GSK3B GSK3B TEK TEK CASS4 CASS4 PLG PLG A0A4W2CX55 A0A4W2CX55 COL16A1 COL16A1 ABL1 ABL1 KANK1 KANK1 FERMT2 FERMT2 LOC113879851 LOC113879851 A0A4W2CQU2 A0A4W2CQU2 MYOC MYOC ONECUT1 ONECUT1 CRKL CRKL RIN2 RIN2 ILK ILK NID1 NID1 PRKCE PRKCE FZD7 FZD7 A0A4W2CEF6 A0A4W2CEF6 EGFLAM EGFLAM P4HB P4HB ALOX15 ALOX15 A0A4W2CAT2 A0A4W2CAT2 RAC1 RAC1 FOXF1 FOXF1 FBLN2 FBLN2 THBS1 THBS1 TBCD TBCD HSD17B12 HSD17B12 VIT VIT ITGB1BP1 ITGB1BP1 LOC113905846 LOC113905846 TESK1 TESK1 CCL28 CCL28 PTPRJ PTPRJ PDPN PDPN FN1 FN1 RREB1 RREB1 NF1 NF1 FUT1 FUT1 CORO1C CORO1C VTN VTN NRP1 NRP1 ACTN4 ACTN4 AP1AR AP1AR NPNT NPNT WDPCP WDPCP VEGFA VEGFA PIK3CB PIK3CB NOTCH1 NOTCH1 EFEMP2 EFEMP2 A0A4W2DWP3 A0A4W2DWP3 SFRP1 SFRP1 ROCK1 ROCK1 LDB1 LDB1 GCNT2 GCNT2 DOCK5 DOCK5 TSC1 TSC1 CRK CRK A0A4W2DQB1 A0A4W2DQB1 EDIL3 EDIL3 A0A4W2DN71 A0A4W2DN71 FETUB FETUB RELL2 RELL2 LIMS2 LIMS2 LIMCH1 LIMCH1 CDC42 CDC42 SPRY4 SPRY4 MACF1 MACF1 ADAM15 ADAM15 KDR KDR DMTN DMTN BST1 BST1 BCL6 BCL6 HOXA7 HOXA7 MELTF MELTF PIK3R1 PIK3R1 RAC3 RAC3 UNC13D UNC13D A0A4W2C4R8 A0A4W2C4R8 A0A4W2C4Q3 A0A4W2C4Q3 CARMIL1 CARMIL1 PDGFB PDGFB PEAK1 PEAK1 MMP12 MMP12 RAC2 RAC2 EPB41L5 EPB41L5 A0A4W2C190 A0A4W2C190 RRAS RRAS CORO2B CORO2B FBLN1 FBLN1 SEMA3E SEMA3E COL8A1 COL8A1 ABI3BP ABI3BP COL1A1 COL1A1 EGFL6 EGFL6 JAG1 JAG1 SPOCK1 SPOCK1 RHOA RHOA SLK SLK SPOCK2 SPOCK2 FZD4 FZD4 CCL21 CCL21 CIB1 CIB1 WNT1 WNT1 MYADM MYADM RASA1 RASA1 SKAP1 SKAP1 VWC2 VWC2 CDK6 CDK6 STK4 STK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIMS1LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (397 aa)
DDR1Tyrosine-protein kinase receptor. (915 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
ANGPT2Angiopoietin 2. (496 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1653 aa)
LOC113879884Uncharacterized protein. (317 aa)
EPHA3EPH receptor A3. (984 aa)
RSU1Ras suppressor protein 1. (277 aa)
EMILIN1Elastin microfibril interfacer 1. (1015 aa)
CDH13Cadherin 13. (713 aa)
PLEKHA2Pleckstrin homology domain containing A2. (425 aa)
ONECUT2One cut domain family member. (557 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
DLC1DLC1 Rho GTPase activating protein. (1169 aa)
PLAUPlasminogen activator, urokinase. (433 aa)
A0A4W2BLC1Uncharacterized protein. (146 aa)
A0A4W2BMR3Rho-GAP domain-containing protein. (263 aa)
A0A4W2BPH2Uncharacterized protein. (294 aa)
VCLVinculin. (1134 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (830 aa)
CORO2ACoronin; Belongs to the WD repeat coronin family. (581 aa)
JUPJunction plakoglobin. (745 aa)
S100A10S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (813 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (672 aa)
ECM2Extracellular matrix protein 2. (720 aa)
TACSTD2Tumor associated calcium signal transducer 2. (319 aa)
RCC2Regulator of chromosome condensation 2. (520 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1008 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (575 aa)
EPHA1EPH receptor A1. (1076 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (254 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
CAMSAP3CKK domain-containing protein. (171 aa)
CCN1Cellular communication network factor 1. (463 aa)
FMN1Formin 1. (1419 aa)
THY1Thy-1 cell surface antigen. (161 aa)
CCL25SCY domain-containing protein. (235 aa)
CCDC80Coiled-coil domain containing 80. (954 aa)
UTRNUtrophin. (3432 aa)
FERMT1Fermitin family member 1. (711 aa)
AJAP1Adherens junctions associated protein 1. (416 aa)
APODApolipoprotein D. (217 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (319 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1343 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
CASS4Cas scaffold protein family member 4. (811 aa)
PLGPlasminogen; Belongs to the peptidase S1 family. (849 aa)
A0A4W2CX55Uncharacterized protein. (245 aa)
COL16A1Collagen type XVI alpha 1 chain. (1625 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
KANK1KN motif and ankyrin repeat domains 1. (1384 aa)
FERMT2Fermitin family member 2. (706 aa)
LOC113879851Uncharacterized protein. (303 aa)
A0A4W2CQU2Uncharacterized protein. (315 aa)
MYOCMyocilin. (490 aa)
ONECUT1One cut domain family member. (712 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
RIN2Ras and Rab interactor 2. (909 aa)
ILKIntegrin linked kinase. (452 aa)
NID1Nidogen 1. (1241 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
A0A4W2CEF6Integrin beta; Belongs to the integrin beta chain family. (784 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (1048 aa)
P4HBProtein disulfide-isomerase. (565 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
A0A4W2CAT2MARVEL domain-containing protein. (335 aa)
RAC1Rac family small GTPase 1. (257 aa)
FOXF1Forkhead box F1. (481 aa)
FBLN2Fibulin 2. (1285 aa)
THBS1Thrombospondin 1. (1170 aa)
TBCDTubulin folding cofactor D. (1226 aa)
HSD17B12Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (370 aa)
VITVitrin. (656 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
LOC113905846Uncharacterized protein. (275 aa)
TESK1Testis associated actin remodelling kinase 1. (630 aa)
CCL28C-C motif chemokine. (127 aa)
PTPRJPeptidylprolyl isomerase. (1344 aa)
PDPNUncharacterized protein. (169 aa)
FN1Fibronectin 1. (2601 aa)
RREB1Ras responsive element binding protein 1. (1456 aa)
NF1Neurofibromin 1. (3024 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (416 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (493 aa)
VTNSMB domain-containing protein. (476 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ACTN4Actinin alpha 4. (933 aa)
AP1ARAdaptor related protein complex 1 associated regulatory protein. (302 aa)
NPNTNephronectin. (616 aa)
WDPCPWD repeat containing planar cell polarity effector. (609 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
NOTCH1Notch receptor 1. (2533 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
A0A4W2DWP3Uncharacterized protein. (1275 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
LDB1LIM domain binding 1. (411 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1864 aa)
TSC1TSC complex subunit 1. (1165 aa)
CRKCRK proto-oncogene, adaptor protein. (376 aa)
A0A4W2DQB1Coronin; Belongs to the WD repeat coronin family. (262 aa)
EDIL3EGF like repeats and discoidin domains 3. (480 aa)
A0A4W2DN71Uncharacterized protein. (86 aa)
FETUBUncharacterized protein. (705 aa)
RELL2RELT like 2. (303 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (366 aa)
LIMCH1LIM and calponin homology domains 1. (1570 aa)
CDC42Cell division cycle 42. (191 aa)
SPRY4Sprouty RTK signaling antagonist 4. (321 aa)
MACF1Microtubule actin crosslinking factor 1. (7557 aa)
ADAM15ADAM metallopeptidase domain 15. (908 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
DMTNDematin actin binding protein. (467 aa)
BST1Bone marrow stromal cell antigen 1. (371 aa)
BCL6BCL6 transcription repressor. (706 aa)
HOXA7Homeobox A7. (238 aa)
MELTFMelanotransferrin; Belongs to the transferrin family. (739 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RAC3Rac family small GTPase 3. (258 aa)
UNC13DUnc-13 homolog D. (1095 aa)
A0A4W2C4R8Uncharacterized protein. (110 aa)
A0A4W2C4Q3PH domain-containing protein. (805 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1426 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PEAK1Pseudopodium enriched atypical kinase 1. (1747 aa)
MMP12Matrix metallopeptidase 12. (471 aa)
RAC2Rac family small GTPase 2. (209 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (726 aa)
A0A4W2C190Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (281 aa)
RRASRAS related. (218 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (503 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (711 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (763 aa)
COL8A1Collagen type VIII alpha 1 chain. (745 aa)
ABI3BPABI family member 3 binding protein. (872 aa)
COL1A1Collagen type I alpha 1 chain. (1584 aa)
EGFL6EGF like domain multiple 6. (523 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (439 aa)
RHOARas homolog family member A. (193 aa)
SLKSTE20 like kinase. (1240 aa)
SPOCK2SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (424 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CCL21C-C motif chemokine ligand 21. (133 aa)
CIB1Calcium and integrin binding 1. (191 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
MYADMMyeloid associated differentiation marker. (322 aa)
RASA1RAS p21 protein activator 1. (1044 aa)
SKAP1Src kinase associated phosphoprotein 1. (380 aa)
VWC2Von Willebrand factor C domain containing 2. (326 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
STK4Serine/threonine kinase 4. (487 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (26%) [HD]