38 items (Bos indicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRS2	Insulin receptor substrate 2. (1325 aa)
	PTH	Parathyroid hormone. (147 aa)
	SLC1A2	Amino acid transporter. (595 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	AKT2	AKT serine/threonine kinase 2. (603 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1125 aa)
	RNASEL	Ribonuclease L. (723 aa)
	MEF2A	Myocyte enhancer factor 2A. (503 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	A0A4W2C5I5	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
	POU4F2	POU domain protein. (408 aa)
	A0A4W2BND6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
	INSR	Tyrosine-protein kinase receptor. (1382 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (328 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	IGF1	Insulin like growth factor 1. (188 aa)
	A0A4W2I3U5	Uncharacterized protein. (296 aa)
	A0A4W2I2L4	Fibrinogen C-terminal domain-containing protein. (301 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (642 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	C1QTNF12	C1q and TNF related 12. (299 aa)
	AKT1	Non-specific serine/threonine protein kinase. (747 aa)
	A0A4W2F0Q7	Fibrinogen C-terminal domain-containing protein. (323 aa)
	C2CD5	C2 calcium dependent domain containing 5. (1137 aa)
	ERFE	Erythroferrone. (340 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (805 aa)
	CLIP3	CAP-Gly domain containing linker protein 3. (547 aa)
	RHOQ	Ras homolog family member Q. (209 aa)
	A0A4W2DZW8	Fibrinogen C-terminal domain-containing protein. (312 aa)
	A0A4W2DFD9	Uncharacterized protein. (305 aa)
	CAPN10	Calpain 10; Belongs to the peptidase C2 family. (645 aa)
	CREBL2	cAMP responsive element binding protein like 2. (120 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (651 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (910 aa)
	C3	Complement C3. (1695 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2BND6	ADIPOQ	A0A4W2BND6	A0A4W2IC39	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Adiponectin, C1Q and collagen domain containing.	0.586
A0A4W2BND6	AKT1	A0A4W2BND6	A0A4W2FNQ0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase.	0.554
A0A4W2BND6	AKT2	A0A4W2BND6	A0A4W2CI15	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	AKT serine/threonine kinase 2.	0.560
A0A4W2BND6	BRAF	A0A4W2BND6	A0A4W2EPG5	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	B-Raf proto-oncogene, serine/threonine kinase.	0.441
A0A4W2BND6	FGF19	A0A4W2BND6	A0A4W2IB60	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
A0A4W2BND6	FGF21	A0A4W2BND6	A0A4W2CMJ6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.510
A0A4W2BND6	IGF1	A0A4W2BND6	A0A4W2I474	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin like growth factor 1.	0.913
A0A4W2BND6	INSR	A0A4W2BND6	A0A4W2IP97	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.982
A0A4W2BND6	IRS2	A0A4W2BND6	A0A4W2CV17	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 2.	0.895
A0A4W2BND6	NFE2L2	A0A4W2BND6	A0A4W2HBT0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Nuclear factor, erythroid 2 like 2.	0.433
A0A4W2BND6	PTH	A0A4W2BND6	A0A4W2CQA5	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Parathyroid hormone.	0.420
A0A4W2BND6	TERT	A0A4W2BND6	A0A4W2CF54	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.416
A0A4W2C5I5	ADIPOQ	A0A4W2C5I5	A0A4W2IC39	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Adiponectin, C1Q and collagen domain containing.	0.586
A0A4W2C5I5	AKT1	A0A4W2C5I5	A0A4W2FNQ0	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase.	0.554
A0A4W2C5I5	AKT2	A0A4W2C5I5	A0A4W2CI15	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	AKT serine/threonine kinase 2.	0.560
A0A4W2C5I5	BRAF	A0A4W2C5I5	A0A4W2EPG5	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	B-Raf proto-oncogene, serine/threonine kinase.	0.441
A0A4W2C5I5	FGF19	A0A4W2C5I5	A0A4W2IB60	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
A0A4W2C5I5	FGF21	A0A4W2C5I5	A0A4W2CMJ6	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.510
A0A4W2C5I5	IGF1	A0A4W2C5I5	A0A4W2I474	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin like growth factor 1.	0.951
A0A4W2C5I5	INSR	A0A4W2C5I5	A0A4W2IP97	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.982

page 1 of 7

Server load: low (14%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About