STRINGSTRING
BCR BCR SHANK1 SHANK1 ADAM22 ADAM22 DGCR8 DGCR8 DVL1 DVL1 ALS2 ALS2 LRFN2 LRFN2 SPTBN1 SPTBN1 A0A4W2CIF5 A0A4W2CIF5 RPS3 RPS3 SHISA7 SHISA7 CACNG5 CACNG5 A0A4W2CEE9 A0A4W2CEE9 EIF3A EIF3A A0A4W2CDP2 A0A4W2CDP2 LRFN5 LRFN5 NOS1 NOS1 NETO2 NETO2 RPLP0 RPLP0 NRGN NRGN PSD PSD CACNA1C CACNA1C PPP1R9A PPP1R9A A0A4W2DG55 A0A4W2DG55 CAPZB CAPZB SEMA4C SEMA4C GAP43 GAP43 PKP4 PKP4 SYT11 SYT11 PDPK1 PDPK1 PAK2 PAK2 CACNG2 CACNG2 PCLO PCLO KCND3 KCND3 DNM2 DNM2 EEF2K EEF2K MAPK8IP2 MAPK8IP2 TSC1 TSC1 PALM PALM SORCS3 SORCS3 GSG1L GSG1L PRRT1 PRRT1 SHISA8 SHISA8 PTPRO PTPRO SHISA9 SHISA9 BSN BSN SYNJ2BP SYNJ2BP GPER1 GPER1 INSYN2A INSYN2A CPEB4 CPEB4 MAP1B MAP1B LIN7C LIN7C GRIN2C GRIN2C ADCY8 ADCY8 SCRIB SCRIB ADGRB1 ADGRB1 SHISA6 SHISA6 DLG4 DLG4 CAP2 CAP2 LIN7B LIN7B SLC8A2 SLC8A2 ADD2 ADD2 PLCB4 PLCB4 SYNDIG1 SYNDIG1 ATP2B2 ATP2B2 ADCY1 ADCY1 RTN4 RTN4 CACNG4 CACNG4 A0A4W2EBE5 A0A4W2EBE5 GRIN2D GRIN2D SYNGAP1 SYNGAP1 GRIN2A GRIN2A TSC2 TSC2 GRM5 GRM5 DTNBP1 DTNBP1 ITPR1 ITPR1 CAMK1 CAMK1 CTNNB1 CTNNB1 GNG3 GNG3 RTN3 RTN3 A0A4W2BTS8 A0A4W2BTS8 CNIH2 CNIH2 CDH2 CDH2 CADM1 CADM1 SHANK2 SHANK2 DBNL DBNL GRIN3B GRIN3B DCC DCC SRCIN1 SRCIN1 A0A4W2BZ05 A0A4W2BZ05 A0A4W2BZH9 A0A4W2BZH9 PICK1 PICK1 RGS9 RGS9 BMPR2 BMPR2 ADGRA1 ADGRA1 ARHGAP44 ARHGAP44 NCS1 NCS1 KCNH1 KCNH1 USP50 USP50 FYN FYN GRIK2 GRIK2 USP8 USP8 KPNA1 KPNA1 SORCS2 SORCS2 NPTN NPTN FXR1 FXR1 AKAP5 AKAP5 RGS14 RGS14 SLITRK3 SLITRK3 ABHD17A ABHD17A SH2D5 SH2D5 HOMER3 HOMER3 EPS8 EPS8 CLSTN2 CLSTN2 RPS25 RPS25 TMEM108 TMEM108 SYNPO SYNPO GRID2 GRID2 GRM3 GRM3 DNAJC6 DNAJC6 SAMD14 SAMD14 DAGLA DAGLA GRIN2B GRIN2B NEURL1 NEURL1 LRRC4B LRRC4B ABHD17B ABHD17B ABHD17C ABHD17C LRRC4C LRRC4C HOMER2 HOMER2 LRFN4 LRFN4 NTRK2 NTRK2 CACNG8 CACNG8 ATP1A1 ATP1A1 CACNG3 CACNG3 ADAM10 ADAM10 PDE4B PDE4B NETO1 NETO1 LRRC7 LRRC7 EGLN1 EGLN1 DBN1 DBN1 ERBB4 ERBB4 MPP2 MPP2 DLG5 DLG5 PPP1R9B PPP1R9B CTNND2 CTNND2 DROSHA DROSHA ADD1 ADD1 HOMER1 HOMER1 SRGAP2 SRGAP2 RNF112 RNF112 ADD3 ADD3 DCLK1 DCLK1 CACNG7 CACNG7 GRIA1 GRIA1 FXR2 FXR2 GRM1 GRM1 FBXO45 FBXO45 GRID1 GRID1 RPL38 RPL38 SLITRK1 SLITRK1 SIGMAR1 SIGMAR1 LIN7A LIN7A PRR12 PRR12 INSYN1 INSYN1 A0A4W2D1D1 A0A4W2D1D1 CRIPT CRIPT DLG1 DLG1 PLPPR4 PLPPR4 LRFN1 LRFN1 DMTN DMTN CDK5 CDK5 ARF1 ARF1 PLEKHA5 PLEKHA5 LRRC4 LRRC4 CLSTN1 CLSTN1 RGS7BP RGS7BP KCND2 KCND2 LZTS3 LZTS3 A0A4W2CQ41 A0A4W2CQ41 CLSTN3 CLSTN3 FABP5 FABP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCRBCR activator of RhoGEF and GTPase. (1283 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (2179 aa)
ADAM22ADAM metallopeptidase domain 22. (974 aa)
DGCR8DGCR8 microprocessor complex subunit. (760 aa)
DVL1Dishevelled segment polarity protein 1. (708 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1656 aa)
LRFN2Leucine rich repeat and fibronectin type III domain containing 2. (786 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2350 aa)
A0A4W2CIF5Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
SHISA7Shisa family member 7. (612 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (424 aa)
A0A4W2CEE940S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (93 aa)
EIF3AEukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] (1376 aa)
A0A4W2CDP2Uncharacterized protein. (200 aa)
LRFN5Leucine rich repeat and fibronectin type III domain containing 5. (717 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
NETO2Neuropilin and tolloid like 2. (525 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (318 aa)
NRGNNeurogranin. (78 aa)
PSDPleckstrin and Sec7 domain containing. (1026 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
PPP1R9AProtein phosphatase 1 regulatory subunit 9A. (1361 aa)
A0A4W2DG55Uncharacterized protein. (399 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (306 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1119 aa)
GAP43Growth associated protein 43. (260 aa)
PKP4Plakophilin 4. (1191 aa)
SYT11Synaptotagmin 11. (461 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (747 aa)
PAK2Non-specific serine/threonine protein kinase. (600 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (300 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5221 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
EEF2KEukaryotic elongation factor 2 kinase. (723 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (863 aa)
TSC1TSC complex subunit 1. (1165 aa)
PALMParalemmin. (219 aa)
SORCS3Sortilin related VPS10 domain containing receptor 3. (1222 aa)
GSG1LGSG1 like. (376 aa)
PRRT1Proline rich transmembrane protein 1. (305 aa)
SHISA8Shisa family member 8. (401 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
SHISA9Shisa family member 9. (425 aa)
BSNBassoon presynaptic cytomatrix protein. (3907 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
INSYN2AInhibitory synaptic factor 2A. (480 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
MAP1BMicrotubule associated protein 1B. (2463 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (872 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
SCRIBScribble planar cell polarity protein. (1603 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1457 aa)
SHISA6Shisa family member 6. (552 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
CAP2Adenylyl cyclase-associated protein; Belongs to the CAP family. (492 aa)
LIN7BProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
ADD2Adducin 2. (724 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
SYNDIG1Synapse differentiation inducing 1. (264 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
RTN4Reticulon. (1200 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (321 aa)
A0A4W2EBE5Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1333 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1300 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
TSC2TSC complex subunit 2. (1887 aa)
GRM5Glutamate metabotropic receptor 5. (1185 aa)
DTNBP1Dystrobrevin binding protein 1. (342 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (369 aa)
CTNNB1Catenin beta 1. (774 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RTN3Reticulon. (1028 aa)
A0A4W2BTS8KRAB domain-containing protein. (281 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (160 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (1318 aa)
CADM1Cell adhesion molecule 1. (478 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1926 aa)
DBNLDrebrin like. (503 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1028 aa)
DCCDCC netrin 1 receptor. (1490 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1475 aa)
A0A4W2BZ05Uncharacterized protein. (246 aa)
A0A4W2BZH9Uncharacterized protein. (727 aa)
PICK1Protein interacting with PRKCA 1. (464 aa)
RGS9Regulator of G protein signaling 9. (639 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ADGRA1Adhesion G protein-coupled receptor A1; Belongs to the G-protein coupled receptor 2 family. (569 aa)
ARHGAP44Rho GTPase activating protein 44. (804 aa)
NCS1Neuronal calcium sensor 1. (370 aa)
KCNH1Uncharacterized protein. (987 aa)
USP50Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (373 aa)
FYNTyrosine-protein kinase. (537 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1084 aa)
KPNA1Karyopherin subunit alpha 1. (954 aa)
SORCS2Sortilin related VPS10 domain containing receptor 2. (1196 aa)
NPTNNeuroplastin. (471 aa)
FXR1FMR1 autosomal homolog 1. (648 aa)
AKAP5A-kinase anchoring protein 5. (428 aa)
RGS14Regulator of G protein signaling 14. (565 aa)
SLITRK3SLIT and NTRK like family member 3. (980 aa)
ABHD17AAbhydrolase domain containing 17A. (310 aa)
SH2D5SH2 domain containing 5. (428 aa)
HOMER3WH1 domain-containing protein. (358 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (836 aa)
CLSTN2Calsyntenin 2. (955 aa)
RPS2540S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (125 aa)
TMEM108Transmembrane protein 108. (642 aa)
SYNPOSynaptopodin. (1131 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (971 aa)
SAMD14Sterile alpha motif domain containing 14. (499 aa)
DAGLADiacylglycerol lipase alpha. (1041 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1497 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
LRRC4BLeucine rich repeat containing 4B. (715 aa)
ABHD17BAbhydrolase domain containing 17B. (294 aa)
ABHD17CAbhydrolase domain containing 17C. (365 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
HOMER2Homer scaffold protein 2. (354 aa)
LRFN4Leucine rich repeat and fibronectin type III domain containing 4. (748 aa)
NTRK2Tyrosine-protein kinase receptor. (837 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (426 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
PDE4BPhosphodiesterase. (736 aa)
NETO1Neuropilin and tolloid like 1. (533 aa)
LRRC7Leucine rich repeat containing 7. (1594 aa)
EGLN1Uncharacterized protein. (420 aa)
DBN1Drebrin 1. (726 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
MPP2Membrane palmitoylated protein 2; Belongs to the MAGUK family. (569 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1946 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (817 aa)
CTNND2Catenin delta 2. (1226 aa)
DROSHADrosha ribonuclease III. (1376 aa)
ADD1Adducin 1. (769 aa)
HOMER1Homer scaffold protein 1. (358 aa)
SRGAP2Uncharacterized protein. (1084 aa)
RNF112Ring finger protein 112. (795 aa)
ADD3Adducin 3. (706 aa)
DCLK1Doublecortin like kinase 1. (741 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
FXR2FMR1 autosomal homolog 2. (673 aa)
GRM1Glutamate metabotropic receptor 1. (1192 aa)
FBXO45F-box protein 45. (281 aa)
GRID1Glutamate ionotropic receptor delta type subunit 1. (1009 aa)
RPL38Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (267 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
PRR12Proline rich 12. (2041 aa)
INSYN1Inhibitory synaptic factor 1. (292 aa)
A0A4W2D1D1Uncharacterized protein. (174 aa)
CRIPTCXXC repeat containing interactor of PDZ3 domain. (101 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
PLPPR4Phospholipid phosphatase related 4. (763 aa)
LRFN1Leucine rich repeat and fibronectin type III domain containing 1. (835 aa)
DMTNDematin actin binding protein. (467 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
PLEKHA5Pleckstrin homology domain containing A5. (1346 aa)
LRRC4Leucine rich repeat containing 4. (652 aa)
CLSTN1Calsyntenin 1. (980 aa)
RGS7BPRegulator of G protein signaling 7 binding protein. (280 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
LZTS3Leucine zipper tumor suppressor family member 3. (672 aa)
A0A4W2CQ41Uncharacterized protein. (620 aa)
CLSTN3Calsyntenin 3. (1049 aa)
FABP5Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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