(49 nodes) Lateral plasma membrane network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	KCNB1	Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
	CTNNB1	Catenin beta 1. (774 aa)
	A0A4W2BU60	Uncharacterized protein. (82 aa)
	MYO1C	Myosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1098 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1710 aa)
	SLC16A3	Solute carrier family 16 member 3. (461 aa)
	APC	APC regulator of WNT signaling pathway. (2912 aa)
	GNA12	G protein subunit alpha 12. (382 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	DVL1	Dishevelled segment polarity protein 1. (708 aa)
	MPP7	Membrane palmitoylated protein 7; Belongs to the MAGUK family. (576 aa)
	A0A4W2CP79	Annexin. (335 aa)
	A0A4W2CRW3	Annexin. (346 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (589 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
	NSG1	Neuronal vesicle trafficking associated 1. (218 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4303 aa)
	ATP2B1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
	LEPR	Leptin receptor. (1165 aa)
	AXIN1	Axin 1. (909 aa)
	SLC26A5	Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (741 aa)
	ABCC1	ATP binding cassette subfamily C member 1. (1544 aa)
	PTPRO	Protein tyrosine phosphatase receptor type O. (1216 aa)
	A0A4W2DX84	C1q domain-containing protein. (386 aa)
	BVES	Blood vessel epicardial substance. (366 aa)
	CLDN7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	RAB13	Uncharacterized protein. (203 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (670 aa)
	VANGL1	Vang-like protein. (537 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
	MYO1A	Myosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1043 aa)
	MARK2	Non-specific serine/threonine protein kinase. (787 aa)
	ATP6V1B1	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1336 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (319 aa)
	SLC12A2	Solute carrier family 12 member 2. (1204 aa)
	ACTN1	Actinin alpha 1. (962 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	NKD2	NKD inhibitor of WNT signaling pathway 2. (483 aa)
	TBCD	Tubulin folding cofactor D. (1226 aa)
	LIN7B	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
	CORO1C	Coronin; Belongs to the WD repeat coronin family. (493 aa)
	EPCAM	Epithelial cell adhesion molecule. (314 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1635 aa)
	LIN7C	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2BU60	CTNNB1	A0A4W2BU60	A0A4W2BQK1	Uncharacterized protein.	Catenin beta 1.	0.466
ABCC1	CDH1	A0A4W2DRF4	A0A4W2CVC4	ATP binding cassette subfamily C member 1.	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	0.418
ABCC1	CTNNB1	A0A4W2DRF4	A0A4W2BQK1	ATP binding cassette subfamily C member 1.	Catenin beta 1.	0.465
APC	AXIN1	A0A4W2C9F4	A0A4W2DL99	APC regulator of WNT signaling pathway.	Axin 1.	0.997
APC	CTNNB1	A0A4W2C9F4	A0A4W2BQK1	APC regulator of WNT signaling pathway.	Catenin beta 1.	0.999
APC	DVL1	A0A4W2C9F4	A0A4W2CL59	APC regulator of WNT signaling pathway.	Dishevelled segment polarity protein 1.	0.927
APC	DVL2	A0A4W2C9F4	A0A4W2CAA8	APC regulator of WNT signaling pathway.	Dishevelled segment polarity protein 2.	0.918
ATP1A1	ATP1B1	A0A4W2GE32	A0A4W2CUX2	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.999
ATP1A1	ATP1B2	A0A4W2GE32	A0A4W2I770	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.974
ATP1B1	ATP1A1	A0A4W2CUX2	A0A4W2GE32	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit alpha.	0.999
ATP1B1	ATP1B2	A0A4W2CUX2	A0A4W2I770	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.949
ATP1B1	ATP2B1	A0A4W2CUX2	A0A4W2D8V1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.446
ATP1B2	ATP1A1	A0A4W2I770	A0A4W2GE32	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit alpha.	0.974
ATP1B2	ATP1B1	A0A4W2I770	A0A4W2CUX2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.949
ATP1B2	ATP2B1	A0A4W2I770	A0A4W2D8V1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.454
ATP2B1	ATP1B1	A0A4W2D8V1	A0A4W2CUX2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.446
ATP2B1	ATP1B2	A0A4W2D8V1	A0A4W2I770	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.454
ATP6V1B1	SLC26A5	A0A4W2FAZ5	A0A4W2DN68	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	0.440
AXIN1	APC	A0A4W2DL99	A0A4W2C9F4	Axin 1.	APC regulator of WNT signaling pathway.	0.997
AXIN1	CTNNB1	A0A4W2DL99	A0A4W2BQK1	Axin 1.	Catenin beta 1.	0.997

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