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MICAL1 MICAL1 A0A4W2BN79 A0A4W2BN79 A0A4W2BNE6 A0A4W2BNE6 A0A4W2BPW1 A0A4W2BPW1 JMJD8 JMJD8 CYP2R1 CYP2R1 SAAL1 SAAL1 CRTAP CRTAP SERGEF SERGEF DBH DBH ALKBH8 ALKBH8 PHF8 PHF8 LOC113892154 LOC113892154 A0A4W2C0J3 A0A4W2C0J3 CYP2E1 CYP2E1 LOC113884563 LOC113884563 SCD SCD ALKBH5 ALKBH5 CYP21A2 CYP21A2 A0A4W2C3M7 A0A4W2C3M7 A0A4W2C3P4 A0A4W2C3P4 MICAL3 MICAL3 A0A4W2C5B8 A0A4W2C5B8 ALKBH2 ALKBH2 A0A4W2C612 A0A4W2C612 DEGS2 DEGS2 CH25H CH25H KDM5A KDM5A NOS1 NOS1 CYP2W1 CYP2W1 SC5D SC5D P4HB P4HB COQ7 COQ7 KDM3A KDM3A P4HA1 P4HA1 LOC113876480 LOC113876480 CYP1A2 CYP1A2 CYP39A1 CYP39A1 LOC113876483 LOC113876483 LOC113884309 LOC113884309 A0A4W2CJP4 A0A4W2CJP4 FADS6 FADS6 A0A4W2CK53 A0A4W2CK53 ASPH ASPH A0A4W2CM56 A0A4W2CM56 A0A4W2CM65 A0A4W2CM65 LOC113903407 LOC113903407 ALKBH3 ALKBH3 CYP27A1 CYP27A1 CYP24A1 CYP24A1 A0A4W2CQH2 A0A4W2CQH2 LOC113903416 LOC113903416 A0A4W2CQT0 A0A4W2CQT0 TET3 TET3 KMO KMO TMEM189 TMEM189 CCNDBP1 CCNDBP1 KDM4C KDM4C MOXD1 MOXD1 CYP11A1 CYP11A1 AKR1D1 AKR1D1 PTGS1 PTGS1 HSPBAP1 HSPBAP1 PHYH PHYH CYP7B1 CYP7B1 P3H2 P3H2 KDM7A KDM7A NOS3 NOS3 DOHH DOHH SCD5 SCD5 FMO3 FMO3 TPH2 TPH2 CYP4B1 CYP4B1 CYP4F22 CYP4F22 TYRP1 TYRP1 LOC113889809 LOC113889809 KDM4A KDM4A RIOX2 RIOX2 LOC113889930 LOC113889930 ALKBH4 ALKBH4 METTL26 METTL26 HMOX1 HMOX1 COQ6 COQ6 CYP8B1 CYP8B1 FADS1 FADS1 A0A4W2DQ91 A0A4W2DQ91 A0A4W2DQP0 A0A4W2DQP0 LOC113883746 LOC113883746 A0A4W2DQS6 A0A4W2DQS6 A0A4W2DQS9 A0A4W2DQS9 PIGS PIGS NOS2 NOS2 KDM8 KDM8 KDM1A KDM1A HIF1AN HIF1AN A0A4W2DVL4 A0A4W2DVL4 A0A4W2DWB8 A0A4W2DWB8 CYP4X1 CYP4X1 P4HTM P4HTM TTI2 TTI2 LOC113884536 LOC113884536 KDM2B KDM2B A0A4W2E2H5 A0A4W2E2H5 A0A4W2E2T7 A0A4W2E2T7 A0A4W2E4A4 A0A4W2E4A4 KDM6B KDM6B P3H3 P3H3 OGFOD3 OGFOD3 TH TH FADS2 FADS2 OGFOD1 OGFOD1 CYP1A1 CYP1A1 A0A4W2E8P8 A0A4W2E8P8 A0A4W2E9C4 A0A4W2E9C4 CYP2F1 CYP2F1 SQLE SQLE FMO2 FMO2 PCBD1 PCBD1 P4HA3 P4HA3 A0A4W2EEW9 A0A4W2EEW9 A0A4W2EEY0 A0A4W2EEY0 CYP1B1 CYP1B1 CYP26B1 CYP26B1 LOC113903405 LOC113903405 PTGIS PTGIS PLOD1 PLOD1 FTO FTO FMO4 FMO4 EGLN3 EGLN3 A0A4W2EKX7 A0A4W2EKX7 PAM PAM TBXAS1 TBXAS1 KDM4B KDM4B ALKBH1 ALKBH1 LOC113890876 LOC113890876 RIOX1 RIOX1 PHF2 PHF2 RSBN1 RSBN1 FMO5 FMO5 CYP51A1 CYP51A1 P3H1 P3H1 JMJD4 JMJD4 AGMO AGMO A0A4W2F007 A0A4W2F007 A0A4W2F1T9 A0A4W2F1T9 A0A4W2F2H5 A0A4W2F2H5 TET2 TET2 CYP2U1 CYP2U1 CYP27C1 CYP27C1 TYW5 TYW5 JMJD6 JMJD6 KDM1B KDM1B CYP27B1 CYP27B1 BBOX1 BBOX1 CYP19A1 CYP19A1 CYP46A1 CYP46A1 LOC113896075 LOC113896075 A0A4W2G525 A0A4W2G525 P4HA2 P4HA2 OGFOD2 OGFOD2 TET1 TET1 KDM5B KDM5B EGLN1 EGLN1 PTGS2 PTGS2 MSMO1 MSMO1 CATSPER3-2 CATSPER3-2 PLOD2 PLOD2 HMOX2 HMOX2 LOC113881341 LOC113881341 FADS3 FADS3 TYR TYR CYP4V2 CYP4V2 EGLN2 EGLN2 CYP2S1 CYP2S1 KDM2A KDM2A CYP7A1 CYP7A1 PAH PAH FMO1 FMO1 CYP26C1 CYP26C1 JMJD7 JMJD7 CYP26A1 CYP26A1 DEGS1 DEGS1 CYP20A1 CYP20A1 P3H4 P3H4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1070 aa)
A0A4W2BN79Uncharacterized protein. (1406 aa)
A0A4W2BNE6BH4_AAA_HYDROXYL_2 domain-containing protein. (571 aa)
A0A4W2BPW1Uncharacterized protein; Belongs to the cytochrome P450 family. (441 aa)
JMJD8Jumonji domain containing 8. (269 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (501 aa)
SAAL1Serum amyloid A like 1. (475 aa)
CRTAPUncharacterized protein. (401 aa)
SERGEFUncharacterized protein. (917 aa)
DBHDopamine beta-hydroxylase. (621 aa)
ALKBH8AlkB homolog 8, tRNA methyltransferase. (681 aa)
PHF8PHD finger protein 8. (1060 aa)
LOC113892154Uncharacterized protein. (533 aa)
A0A4W2C0J3Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
CYP2E1Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (509 aa)
LOC113884563Uncharacterized protein; Belongs to the cytochrome P450 family. (492 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (497 aa)
A0A4W2C3M7Uncharacterized protein; Belongs to the cytochrome P450 family. (424 aa)
A0A4W2C3P4Uncharacterized protein. (207 aa)
MICAL3Microtubule associated monooxygenase, calponin and LIM domain containing 3. (2087 aa)
A0A4W2C5B8Uncharacterized protein; Belongs to the cytochrome P450 family. (538 aa)
ALKBH2AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase. (278 aa)
A0A4W2C612Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (326 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (270 aa)
KDM5ALysine demethylase 5A. (1690 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (491 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (359 aa)
P4HBProtein disulfide-isomerase. (565 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (262 aa)
KDM3ALysine demethylase 3A. (1340 aa)
P4HA1Prolyl 4-hydroxylase subunit alpha 1. (534 aa)
LOC113876480Uncharacterized protein; Belongs to the cytochrome P450 family. (492 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (486 aa)
LOC113876483Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
LOC113884309PHB domain-containing protein; Belongs to the cytochrome P450 family. (598 aa)
A0A4W2CJP4Cytochrome b5 heme-binding domain-containing protein. (467 aa)
FADS6Fatty acid desaturase 6. (353 aa)
A0A4W2CK53Cytochrome b5 heme-binding domain-containing protein. (485 aa)
ASPHAspartate beta-hydroxylase. (767 aa)
A0A4W2CM56Aldo_ket_red domain-containing protein. (323 aa)
A0A4W2CM65Aldo_ket_red domain-containing protein. (166 aa)
LOC113903407Aldo_ket_red domain-containing protein. (326 aa)
ALKBH3AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (286 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (541 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (561 aa)
A0A4W2CQH2Aldo_ket_red domain-containing protein. (196 aa)
LOC113903416Aldo_ket_red domain-containing protein. (323 aa)
A0A4W2CQT0Aldo_ket_red domain-containing protein. (355 aa)
TET3Tet methylcytosine dioxygenase 3. (1792 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (471 aa)
TMEM189Transmembrane protein 189. (316 aa)
CCNDBP1Cyclin D1 binding protein 1. (358 aa)
KDM4CLysine demethylase 4C. (1053 aa)
MOXD1DOMON domain-containing protein. (614 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (536 aa)
AKR1D1Aldo-keto reductase family 1 member D1. (326 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (635 aa)
HSPBAP1HSPB1 associated protein 1. (447 aa)
PHYHUncharacterized protein. (337 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (510 aa)
P3H2Prolyl 3-hydroxylase 2. (705 aa)
KDM7ALysine demethylase 7A. (942 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
DOHHDeoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. (405 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (335 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
TPH2Tryptophan hydroxylase 2. (491 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
CYP4F22Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (531 aa)
TYRP1Tyrosinase related protein 1. (596 aa)
LOC113889809Uncharacterized protein. (829 aa)
KDM4AUncharacterized protein. (1066 aa)
RIOX2Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (535 aa)
LOC113889930Uncharacterized protein. (906 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (303 aa)
METTL26Methyltransferase like 26. (204 aa)
HMOX1Heme oxygenase 1. (302 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (485 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (499 aa)
FADS1Fatty acid desaturase 1. (474 aa)
A0A4W2DQ91Uncharacterized protein. (474 aa)
A0A4W2DQP0Uncharacterized protein. (503 aa)
LOC113883746Uncharacterized protein. (504 aa)
A0A4W2DQS6Uncharacterized protein. (398 aa)
A0A4W2DQS9Uncharacterized protein. (374 aa)
PIGSPhosphatidylinositol glycan anchor biosynthesis class S. (641 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
KDM8Lysine demethylase 8. (406 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (877 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (349 aa)
A0A4W2DVL4Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
A0A4W2DWB8Uncharacterized protein; Belongs to the cytochrome P450 family. (525 aa)
CYP4X1Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (515 aa)
P4HTMProlyl 4-hydroxylase, transmembrane. (494 aa)
TTI2TELO2 interacting protein 2. (531 aa)
LOC113884536Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
KDM2BLysine demethylase 2B. (1424 aa)
A0A4W2E2H5Uncharacterized protein. (67 aa)
A0A4W2E2T7Uncharacterized protein. (159 aa)
A0A4W2E4A4Uncharacterized protein. (503 aa)
KDM6BLysine demethylase 6B. (1665 aa)
P3H3Prolyl 3-hydroxylase 3. (751 aa)
OGFOD32-oxoglutarate and iron dependent oxygenase domain containing 3. (315 aa)
THBH4_AAA_HYDROXYL_2 domain-containing protein. (536 aa)
FADS2Fatty acid desaturase 2. (594 aa)
OGFOD12-oxoglutarate and iron dependent oxygenase domain containing 1. (603 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
A0A4W2E8P8DOMON domain-containing protein. (575 aa)
A0A4W2E9C4Uncharacterized protein. (186 aa)
CYP2F1Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (550 aa)
SQLESqualene epoxidase. (572 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
PCBD1Pterin-4 alpha-carbinolamine dehydratase 1. (104 aa)
P4HA3Prolyl 4-hydroxylase subunit alpha 3. (544 aa)
A0A4W2EEW9Uncharacterized protein. (1936 aa)
A0A4W2EEY0Uncharacterized protein. (297 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (539 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
LOC113903405Aldo_ket_red domain-containing protein. (323 aa)
PTGISProstaglandin I2 synthase. (543 aa)
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (726 aa)
FTOFTO alpha-ketoglutarate dependent dioxygenase. (521 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (550 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
A0A4W2EKX7Aldo_ket_red domain-containing protein. (290 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (972 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (580 aa)
KDM4BLysine demethylase 4B. (1116 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
LOC113890876DOMON domain-containing protein. (618 aa)
RIOX1Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (667 aa)
PHF2PHD finger protein 2. (1091 aa)
RSBN1Round spermatid basic protein 1. (803 aa)
FMO5Flavin-containing monooxygenase. (644 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (510 aa)
P3H1Prolyl 3-hydroxylase 1. (736 aa)
JMJD4Jumonji domain containing 4. (580 aa)
AGMOAlkylglycerol monooxygenase; Belongs to the sterol desaturase family. (531 aa)
A0A4W2F007Uncharacterized protein; Belongs to the cytochrome P450 family. (564 aa)
A0A4W2F1T9Dimethylaniline monooxygenase [N-oxide-forming]. (515 aa)
A0A4W2F2H5Uncharacterized protein. (65 aa)
TET2Tet methylcytosine dioxygenase 2. (2007 aa)
CYP2U1Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (543 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (537 aa)
TYW5tRNA-yW synthesizing protein 5. (315 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (414 aa)
KDM1BLysine demethylase 1B. (921 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
BBOX1Gamma-butyrobetaine hydroxylase 1. (387 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
LOC113896075Uncharacterized protein. (572 aa)
A0A4W2G525Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (535 aa)
OGFOD22-oxoglutarate and iron dependent oxygenase domain containing 2. (350 aa)
TET1Tet methylcytosine dioxygenase 1. (2137 aa)
KDM5BLysine demethylase 5B. (1539 aa)
EGLN1Uncharacterized protein. (420 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
MSMO1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa)
CATSPER3-2Pterin-4 alpha-carbinolamine dehydratase 2. (130 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (792 aa)
HMOX2Heme oxygenase 2. (334 aa)
LOC113881341Rieske domain-containing protein. (577 aa)
FADS3Fatty acid desaturase 3. (443 aa)
TYRTyrosinase. (530 aa)
CYP4V2Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (527 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (464 aa)
CYP2S1Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (494 aa)
KDM2ALysine demethylase 2A. (1185 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (500 aa)
PAHPhenylalanine hydroxylase. (451 aa)
FMO1Flavin-containing monooxygenase. (612 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (523 aa)
JMJD7Jumonji domain containing 7. (316 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (323 aa)
CYP20A1Cytochrome P450 family 20 subfamily A member 1. (468 aa)
P3H4Prolyl 3-hydroxylase family member 4 (non-enzymatic). (442 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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