STRINGSTRING
DACT1 DACT1 IFT140 IFT140 CLUAP1 CLUAP1 PKD1 PKD1 KAT5 KAT5 INKA1 INKA1 NODAL NODAL PLXNB2 PLXNB2 RARA RARA MED12 MED12 SUFU SUFU CASP3 CASP3 PTK7 PTK7 CECR2 CECR2 A0A4W2C5U2 A0A4W2C5U2 RPGRIP1L RPGRIP1L TRIM71 TRIM71 GSC GSC DVL2 DVL2 INTU INTU TGFB1 TGFB1 DVL1 DVL1 HES5 HES5 STK3 STK3 ITPK1 ITPK1 A0A4W2CR26 A0A4W2CR26 FOXB1 FOXB1 CITED2 CITED2 ABL1 ABL1 GLI3 GLI3 TBC1D32 TBC1D32 PHACTR4 PHACTR4 DCHS1 DCHS1 BBS4 BBS4 RARG RARG PTCH1 PTCH1 FZD6 FZD6 GRHL2 GRHL2 ZFP36L1 ZFP36L1 MTHFR MTHFR PHGDH PHGDH LIAS LIAS BMP7 BMP7 PKD2 PKD2 DZIP1L DZIP1L GDF7 GDF7 SEMA4C SEMA4C SEC24B SEC24B TWIST1 TWIST1 TBXT TBXT SOX4 SOX4 HES1 HES1 ST14 ST14 MKS1 MKS1 SETD2 SETD2 TSC1 TSC1 LRRC1 LRRC1 LRP2 LRP2 LUZP1 LUZP1 MIB1 MIB1 RNF220 RNF220 SFRP2 SFRP2 SFRP1 SFRP1 NOTCH1 NOTCH1 TMEM107 TMEM107 KDM2B KDM2B NUP133 NUP133 EN1 EN1 KAT2A KAT2A SPINT2 SPINT2 SCRIB SCRIB PAX6 PAX6 NF1 NF1 A0A4W2E7C9 A0A4W2E7C9 TCTN1 TCTN1 RALA RALA SOX17 SOX17 CELSR1 CELSR1 MTHFD1L MTHFD1L SPINT1 SPINT1 AMBRA1 AMBRA1 CBY1 CBY1 CTHRC1 CTHRC1 TULP3 TULP3 BMP4 BMP4 FOXA1 FOXA1 C2CD3 C2CD3 SALL4 SALL4 BCL10 BCL10 FZD3 FZD3 PSEN1 PSEN1 CC2D2A CC2D2A DVL3 DVL3 MTHFD1 MTHFD1 SHH SHH SHROOM3 SHROOM3 GBX2 GBX2 GRHL3 GRHL3 WDR19 WDR19 EPHA2 EPHA2 SSBP3 SSBP3 APAF1 APAF1 IFT57 IFT57 GLMN GLMN WNT5A WNT5A MARCKS MARCKS FGF8 FGF8 STK4 STK4 BRD2 BRD2 PRKACA PRKACA ALDH1A2 ALDH1A2 FERD3L FERD3L COMMD3 COMMD3 VASP VASP PLXNA2 PLXNA2 SEMA3C SEMA3C ARHGAP35 ARHGAP35 SMO SMO PRICKLE1 PRICKLE1 FZD2 FZD2 PRKACB PRKACB TEAD2 TEAD2 LMO4 LMO4 FUZ FUZ HIF1A HIF1A WNT3A WNT3A IFT52 IFT52 ARL13B ARL13B WNT1 WNT1 LHX2 LHX2 SALL2 SALL2 NOG NOG HECTD1 HECTD1 OPA1 OPA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DACT1Dishevelled binding antagonist of beta catenin 1. (837 aa)
IFT140Intraflagellar transport 140. (1457 aa)
CLUAP1Clusterin associated protein 1. (561 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
INKA1Inka box actin regulator 1. (337 aa)
NODALNodal growth differentiation factor. (346 aa)
PLXNB2Plexin B2. (1985 aa)
RARARetinoic acid receptor alpha. (477 aa)
MED12Mediator complex subunit 12. (2024 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
CECR2CECR2 histone acetyl-lysine reader. (1375 aa)
A0A4W2C5U2Uncharacterized protein. (85 aa)
RPGRIP1LRPGRIP1 like. (1274 aa)
TRIM71Tripartite motif containing 71. (876 aa)
GSCGoosecoid homeobox. (266 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
INTUInturned planar cell polarity protein. (933 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
DVL1Dishevelled segment polarity protein 1. (708 aa)
HES5Hes family bHLH transcription factor 5. (227 aa)
STK3Serine/threonine kinase 3. (491 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase. (609 aa)
A0A4W2CR26TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
FOXB1Forkhead box B1. (325 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
GLI3GLI family zinc finger 3. (1587 aa)
TBC1D32TBC1 domain family member 32. (1313 aa)
PHACTR4Phosphatase and actin regulator. (712 aa)
DCHS1Dachsous cadherin-related 1. (3525 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
RARGRetinoic acid receptor gamma. (519 aa)
PTCH1Patched 1. (1453 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
GRHL2Grainyhead like transcription factor 2. (609 aa)
ZFP36L1ZFP36 ring finger protein like 1. (323 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (696 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (677 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (1071 aa)
DZIP1LDAZ interacting zinc finger protein 1 like. (825 aa)
GDF7Growth differentiation factor 7. (411 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1119 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1459 aa)
TWIST1Twist family bHLH transcription factor 1. (201 aa)
TBXTT-box transcription factor T. (435 aa)
SOX4SRY-box transcription factor 4. (501 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
MKS1MKS transition zone complex subunit 1. (598 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2563 aa)
TSC1TSC complex subunit 1. (1165 aa)
LRRC1Leucine rich repeat containing 1. (762 aa)
LRP2LDL receptor related protein 2. (4647 aa)
LUZP1Leucine zipper protein 1. (1070 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
RNF220Ring finger protein 220. (566 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
NOTCH1Notch receptor 1. (2533 aa)
TMEM107Transmembrane protein 107. (140 aa)
KDM2BLysine demethylase 2B. (1424 aa)
NUP133Nucleoporin 133. (1156 aa)
EN1Homeobox protein engrailed-like. (400 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (250 aa)
SCRIBScribble planar cell polarity protein. (1603 aa)
PAX6Paired box 6. (455 aa)
NF1Neurofibromin 1. (3024 aa)
A0A4W2E7C9TNF receptor-associated factor. (411 aa)
TCTN1Tectonic family member 1. (588 aa)
RALARAS like proto-oncogene A. (206 aa)
SOX17SRY-box transcription factor 17. (410 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3045 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (976 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (513 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1297 aa)
CBY1Chibby family member 1, beta catenin antagonist. (182 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (482 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FOXA1Forkhead box A1. (468 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2339 aa)
SALL4Spalt like transcription factor 4. (1060 aa)
BCL10BCL10 immune signaling adaptor. (230 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1620 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
SHROOM3Shroom family member 3. (1988 aa)
GBX2Gastrulation brain homeobox 2. (349 aa)
GRHL3Grainyhead like transcription factor 3. (638 aa)
WDR19WD repeat domain 19. (1342 aa)
EPHA2EPH receptor A2. (1007 aa)
SSBP3Single stranded DNA binding protein 3. (439 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
IFT57Intraflagellar transport 57. (429 aa)
GLMNGlomulin, FKBP associated protein. (592 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (333 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
STK4Serine/threonine kinase 4. (487 aa)
BRD2Bromodomain containing 2. (803 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
FERD3LFer3 like bHLH transcription factor. (164 aa)
COMMD3RING-type domain-containing protein. (469 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
PLXNA2Plexin A2. (1894 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
PRICKLE1Prickle planar cell polarity protein 1. (834 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
LMO4LIM domain only 4. (165 aa)
FUZFuzzy planar cell polarity protein. (419 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
IFT52Intraflagellar transport 52. (440 aa)
ARL13BADP ribosylation factor like GTPase 13B. (429 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
LHX2LIM homeobox 2. (406 aa)
SALL2Spalt like transcription factor 2. (1003 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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