STRINGSTRING
SLC1A3 SLC1A3 ATP6V1B2 ATP6V1B2 MAPK3 MAPK3 ATP1B2 ATP1B2 RAB39A RAB39A SLC9A5 SLC9A5 ATP6AP2 ATP6AP2 RAB38 RAB38 CLN5 CLN5 CA2 CA2 CLIC4 CLIC4 CA7 CA7 ATP1A1 ATP1A1 SCNN1G SCNN1G ATP1A2 ATP1A2 ATP1A3 ATP1A3 ATP1A4 ATP1A4 SNAPIN SNAPIN ATP6V1B1 ATP6V1B1 SLC9A7 SLC9A7 ATP1B3 ATP1B3 TMPRSS3 TMPRSS3 SLC4A4 SLC4A4 TMEM165 TMEM165 DMXL1 DMXL1 CLN6 CLN6 TMEM175 TMEM175 SLC9C1 SLC9C1 ATP6V0A4 ATP6V0A4 SLC9A2 SLC9A2 DMXL2 DMXL2 ATP5F1B ATP5F1B CHP1 CHP1 ATP6V0D2 ATP6V0D2 UBE3A UBE3A SLC9A4 SLC9A4 GRN GRN ATP4A ATP4A A0A4W2E9C1 A0A4W2E9C1 SLC4A9 SLC4A9 TMEM9 TMEM9 SCNN1B SCNN1B KCNMA1 KCNMA1 TMEM199 TMEM199 ATP6AP1L ATP6AP1L AQP11 AQP11 SLC26A3 SLC26A3 SLC9A9 SLC9A9 TM9SF4 TM9SF4 PPT1 PPT1 SLC4A10 SLC4A10 GPR89A GPR89A SLC4A2 SLC4A2 SLC9A8 SLC9A8 SLC4A8 SLC4A8 LRRK2 LRRK2 SLC9A1 SLC9A1 ATP1B1 ATP1B1 RAB20 RAB20 ATP4B ATP4B MAPK1 MAPK1 SLC4A3 SLC4A3 SLC4A5 SLC4A5 SLC8A1 SLC8A1 SLC11A1 SLC11A1 CFTR CFTR SLC9A3 SLC9A3 ATP6V0A1 ATP6V0A1 IL1A IL1A ATP6V0A2 ATP6V0A2 TCIRG1 TCIRG1 SLC4A1 SLC4A1 SLC26A6 SLC26A6 ATP6V0D1 ATP6V0D1 SCNN1A SCNN1A A0A4W2BYF2 A0A4W2BYF2 TFAP2B TFAP2B UMOD UMOD BCL2 BCL2 SLC4A7 SLC4A7 RAB7A RAB7A A0A4W2BQI8 A0A4W2BQI8 CLN3 CLN3 ATP12A ATP12A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC1A3Amino acid transporter. (542 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
SLC9A5Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (900 aa)
ATP6AP2Uncharacterized protein. (377 aa)
RAB38RAB38, member RAS oncogene family. (211 aa)
CLN5Uncharacterized protein. (358 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
CA7Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (264 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (652 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (731 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (454 aa)
SLC4A4Anion exchange protein. (1190 aa)
TMEM165GDT1 family protein. (324 aa)
DMXL1Dmx like 1. (3083 aa)
CLN6CLN6 transmembrane ER protein. (380 aa)
TMEM175Transmembrane protein 175. (585 aa)
SLC9C1Solute carrier family 9 member C1. (1145 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
SLC9A2Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
DMXL2Dmx like 2. (3036 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (797 aa)
GRNGranulin precursor. (663 aa)
ATP4ASodium/potassium-transporting ATPase subunit alpha. (1034 aa)
A0A4W2E9C1Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
SLC4A9Anion exchange protein. (957 aa)
TMEM9Transmembrane protein 9. (181 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (736 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1276 aa)
TMEM199Transmembrane protein 199. (268 aa)
ATP6AP1LUncharacterized protein. (381 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (760 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (640 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
PPT1Uncharacterized protein. (336 aa)
SLC4A10Anion exchange protein. (1147 aa)
GPR89AUncharacterized protein. (544 aa)
SLC4A2Anion exchange protein. (1276 aa)
SLC9A8Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (597 aa)
SLC4A8Anion exchange protein. (1092 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (818 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
RAB20RAB20, member RAS oncogene family. (231 aa)
ATP4BSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
SLC4A3Anion exchange protein. (1226 aa)
SLC4A5Anion exchange protein. (1142 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
SLC11A1Solute carrier family 11 member 1. (601 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (835 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (853 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
SLC4A1Anion exchange protein. (1059 aa)
SLC26A6Solute carrier family 26 member 6. (763 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (682 aa)
A0A4W2BYF2Uncharacterized protein. (968 aa)
TFAP2BTranscription factor AP-2 beta. (488 aa)
UMODUromodulin. (643 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
SLC4A7Anion exchange protein. (1241 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
A0A4W2BQI8Uncharacterized protein. (426 aa)
CLN3Battenin. (460 aa)
ATP12ASodium/potassium-transporting ATPase subunit alpha. (1017 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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