STRINGSTRING
RAF1 RAF1 HNF1B HNF1B SNX19 SNX19 PDX1 PDX1 RAPGEF4 RAPGEF4 PCLO PCLO VGF VGF STX1A STX1A ACVR1C ACVR1C GPR68 GPR68 ILDR2 ILDR2 SREBF1 SREBF1 PARK7 PARK7 NEUROD1 NEUROD1 MAFA MAFA SELENOT SELENOT STXBP3 STXBP3 IL1RN IL1RN FAM3B FAM3B HIF1A HIF1A CPLX3 CPLX3 SERP1 SERP1 ADCYAP1 ADCYAP1 RBM4 RBM4 CYB5R4 CYB5R4 RAB11B RAB11B LEP LEP FKBP1B FKBP1B A0A4W2CRW3 A0A4W2CRW3 PTPRN PTPRN HNF1A HNF1A SLC30A8 SLC30A8 A0A4W2CP79 A0A4W2CP79 PRKCE PRKCE FFAR1 FFAR1 RAB11FIP2 RAB11FIP2 A0A4W2C9G4 A0A4W2C9G4 MC4R MC4R CCDC186 CCDC186 SMAD2 SMAD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
HNF1BHNF1 homeobox B. (558 aa)
SNX19Sorting nexin 19. (1057 aa)
PDX1Pancreatic and duodenal homeobox 1. (285 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5221 aa)
VGFVGF nerve growth factor inducible. (656 aa)
STX1ASyntaxin 1A. (373 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (383 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (640 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1146 aa)
PARK7Parkinsonism associated deglycase. (190 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
MAFAMAF bZIP transcription factor A. (351 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (194 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (576 aa)
IL1RNInterleukin-1. (250 aa)
FAM3BFamily with sequence similarity 3 member B. (266 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
CPLX3Complexin 3. (158 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (197 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
RBM4RNA binding motif protein 4. (362 aa)
CYB5R4Cytochrome b5 reductase 4. (617 aa)
RAB11BUncharacterized protein. (267 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
A0A4W2CRW3Annexin. (346 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
HNF1AHNF1 homeobox A. (633 aa)
SLC30A8Solute carrier family 30 member 8. (350 aa)
A0A4W2CP79Annexin. (335 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
RAB11FIP2RAB11 family interacting protein 2. (511 aa)
A0A4W2C9G4Uncharacterized protein. (232 aa)
MC4RMelanocortin 4 receptor. (333 aa)
CCDC186Coiled-coil domain containing 186. (899 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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