STRINGSTRING
TP53 TP53 BRCA2 BRCA2 PIDD1 PIDD1 KAT5 KAT5 A0A4W2BZA0 A0A4W2BZA0 A0A4W2C0C3 A0A4W2C0C3 A0A4W2C3D5 A0A4W2C3D5 MYO6 MYO6 FOXO3 FOXO3 BCL3 BCL3 USP10 USP10 ING4 ING4 SESN2 SESN2 ACER2 ACER2 CRADD CRADD CASP2 CASP2 PAXIP1 PAXIP1 PPM1D PPM1D A0A4W2DWY9 A0A4W2DWY9 CHEK2 CHEK2 NDRG1 NDRG1 PML PML CDKN1A CDKN1A FOXM1 FOXM1 RPS27L RPS27L HIPK2 HIPK2 E2F7 E2F7 A0A4W2EYN7 A0A4W2EYN7 GML GML TFAP4 TFAP4 BATF BATF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
PIDD1P53-induced death domain protein 1. (946 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
A0A4W2BZA0Fork-head domain-containing protein. (697 aa)
A0A4W2C0C340S ribosomal protein S27. (95 aa)
A0A4W2C3D5Uncharacterized protein. (223 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1289 aa)
FOXO3Forkhead box O3. (617 aa)
BCL3BCL3 transcription coactivator. (454 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (800 aa)
ING4Inhibitor of growth protein. (248 aa)
SESN2Sestrin 2. (482 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (319 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (287 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
PAXIP1PAX interacting protein 1. (983 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
A0A4W2DWY9UPAR/Ly6 domain-containing protein. (155 aa)
CHEK2Checkpoint kinase 2. (534 aa)
NDRG1N-myc downstream regulated 1. (415 aa)
PMLPromyelocytic leukemia. (871 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
FOXM1Fork-head domain-containing protein. (760 aa)
RPS27L40S ribosomal protein S27. (102 aa)
HIPK2Homeodomain interacting protein kinase 2. (1205 aa)
E2F7E2F transcription factor 7. (912 aa)
A0A4W2EYN7SEA domain-containing protein. (663 aa)
GMLUPAR/Ly6 domain-containing protein. (155 aa)
TFAP4Transcription factor AP-4. (335 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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