STRINGSTRING
TREM2 TREM2 ZCCHC17 ZCCHC17 AKT1 AKT1 ELAVL4 ELAVL4 SMCR8 SMCR8 TMEM39B TMEM39B USP14 USP14 RNF41 RNF41 MT3 MT3 CTSA CTSA POLDIP2 POLDIP2 FURIN FURIN SNCA SNCA CSNK2A2 CSNK2A2 IGF2BP3 IGF2BP3 SEC22B SEC22B RNF5 RNF5 ADRA1A ADRA1A NUPR1 NUPR1 TIMP3 TIMP3 HNRNPAB HNRNPAB IL10RA IL10RA KLHL40 KLHL40 RASIP1 RASIP1 LZTS1 LZTS1 RBM24 RBM24 E2F1 E2F1 RPL23 RPL23 FHIT FHIT UCHL5 UCHL5 MAPKAPK2 MAPKAPK2 TRIM39 TRIM39 FOXK2 FOXK2 TP53 TP53 WNT1 WNT1 TIGAR TIGAR DAPL1 DAPL1 MYD88 MYD88 TLK2 TLK2 TIMP4 TIMP4 THRAP3 THRAP3 DHX9 DHX9 RBM46 RBM46 CHMP4A CHMP4A LOC113880833 LOC113880833 WAC WAC USP7 USP7 C16orf96 C16orf96 A0A4W2BND6 A0A4W2BND6 A0A4W2BQ76 A0A4W2BQ76 FUS FUS SVIP SVIP TRAF2 TRAF2 WDR6 WDR6 SMARCC1 SMARCC1 BCL2 BCL2 SMG1 SMG1 SUFU SUFU OGT OGT A0A4W2C1F6 A0A4W2C1F6 EHMT2 EHMT2 FEZ1 FEZ1 TRAF5 TRAF5 BAG6 BAG6 PKP1 PKP1 TIMP2 TIMP2 A0A4W2C568 A0A4W2C568 A0A4W2C5I5 A0A4W2C5I5 FOXK1 FOXK1 PABPN1L PABPN1L N4BP1 N4BP1 TAF9 TAF9 APOC3 APOC3 TRAF3IP2 TRAF3IP2 CLEC16A CLEC16A ZFP36 ZFP36 A0A4W2CEA8 A0A4W2CEA8 MEIOC MEIOC NOCT NOCT SYNCRIP SYNCRIP NSUN2 NSUN2 NOP53 NOP53 A0A4W2CJ16 A0A4W2CJ16 AXIN2 AXIN2 IKBKE IKBKE LRPPRC LRPPRC TRDMT1 TRDMT1 SLC11A1 SLC11A1 PABPC1 PABPC1 ACACB ACACB PHF23 PHF23 QSOX1 QSOX1 APOBEC1 APOBEC1 MTOR MTOR DDRGK1 DDRGK1 HTR2B HTR2B SCFD1 SCFD1 HNRNPU HNRNPU LOC113877294 LOC113877294 LEP LEP LRRK2 LRRK2 NBAS NBAS PDCL3 PDCL3 PTPN3 PTPN3 SGTA SGTA ELAVL1 ELAVL1 LRIG2 LRIG2 RUBCN RUBCN CSDE1 CSDE1 FEZ2 FEZ2 EIF3H EIF3H PLIN5 PLIN5 TENT2 TENT2 IGF2BP2 IGF2BP2 EIF4G1 EIF4G1 A0A4W2D9S8 A0A4W2D9S8 KDM4A KDM4A PINK1 PINK1 DHX36 DHX36 LEPR LEPR CAMLG CAMLG HNRNPA0 HNRNPA0 NRDE2 NRDE2 DND1 DND1 MTMR8 MTMR8 A0A4W2DJQ9 A0A4W2DJQ9 HMOX1 HMOX1 SECISBP2 SECISBP2 UBXN1 UBXN1 GIPC2 GIPC2 PHAX PHAX NPC1 NPC1 PARN PARN RBM10 RBM10 RYBP RYBP CCAR2 CCAR2 PKP3 PKP3 SORL1 SORL1 A1CF A1CF ANGEL2 ANGEL2 GPLD1 GPLD1 IGF2BP1 IGF2BP1 TOB1 TOB1 BOLL BOLL BAG5 BAG5 SIRT2 SIRT2 ATP2B4 ATP2B4 DHX34 DHX34 KLHL22 KLHL22 CPTP CPTP DFFB DFFB STAT3 STAT3 A0A4W2EAH7 A0A4W2EAH7 PML PML A0A4W2EAX2 A0A4W2EAX2 BECN1 BECN1 VIP VIP A0A4W2EFF5 A0A4W2EFF5 EIF4ENIF1 EIF4ENIF1 TARDBP TARDBP A0A4W2EHE4 A0A4W2EHE4 BMF BMF TENT5A TENT5A PARK7 PARK7 TENT5B TENT5B LOC113897311 LOC113897311 TMEM39A TMEM39A PBK PBK HIPK2 HIPK2 GIPC3 GIPC3 A0A4W2EQZ6 A0A4W2EQZ6 PSEN1 PSEN1 TBC1D14 TBC1D14 STYX STYX SHH SHH MFSD2A MFSD2A UBQLN4 UBQLN4 ETFBKMT ETFBKMT GIPC1 GIPC1 LARP1 LARP1 DAZL DAZL YBX1 YBX1 GDNF GDNF HFE HFE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TREM2Triggering receptor expressed on myeloid cells 2. (244 aa)
ZCCHC17Zinc finger CCHC-type containing 17. (241 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
ELAVL4ELAV-like protein; Belongs to the RRM elav family. (402 aa)
SMCR8SMCR8-C9orf72 complex subunit. (938 aa)
TMEM39BTransmembrane protein 39B. (492 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
RNF41Ring finger protein 41. (317 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (497 aa)
POLDIP2DNA polymerase delta interacting protein 2. (368 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (797 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (385 aa)
IGF2BP3Insulin like growth factor 2 mRNA binding protein 3. (580 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
RNF5Ring finger protein 5. (180 aa)
ADRA1AAdrenoceptor alpha 1A. (524 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (318 aa)
HNRNPABHeterogeneous nuclear ribonucleoprotein A/B. (332 aa)
IL10RAInterleukin 10 receptor subunit alpha. (580 aa)
KLHL40Kelch like family member 40. (624 aa)
RASIP1Ras interacting protein 1. (963 aa)
LZTS1Leucine zipper tumor suppressor 1. (595 aa)
RBM24RNA binding motif protein 24. (236 aa)
E2F1E2F transcription factor 1. (437 aa)
RPL23Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family. (157 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (328 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa)
TRIM39Tripartite motif containing 39. (488 aa)
FOXK2Forkhead box K2. (658 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
DAPL1Death associated protein like 1. (107 aa)
MYD88MYD88 innate immune signal transduction adaptor. (384 aa)
TLK2Tousled like kinase 2. (796 aa)
TIMP4TIMP metallopeptidase inhibitor 4. (224 aa)
THRAP3Thyroid hormone receptor associated protein 3. (957 aa)
DHX9DExH-box helicase 9. (1287 aa)
RBM46RNA binding motif protein 46. (533 aa)
CHMP4ACharged multivesicular body protein 4A. (265 aa)
LOC113880833Uncharacterized protein. (238 aa)
WACWW domain containing adaptor with coiled-coil. (646 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
C16orf96Chromosome 16 open reading frame 96. (1093 aa)
A0A4W2BND6IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
A0A4W2BQ76USP domain-containing protein; Belongs to the peptidase C19 family. (713 aa)
FUSFUS RNA binding protein. (512 aa)
SVIPUncharacterized protein. (77 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
WDR6WD repeat domain 6. (1181 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1105 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3824 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1036 aa)
A0A4W2C1F6Uncharacterized protein. (278 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1389 aa)
FEZ1Fasciculation and elongation protein zeta 1. (440 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
BAG6BCL2 associated athanogene 6. (1164 aa)
PKP1Plakophilin 1. (727 aa)
TIMP2TIMP metallopeptidase inhibitor 2. (235 aa)
A0A4W2C568Pkinase_Tyr domain-containing protein. (207 aa)
A0A4W2C5I5Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
FOXK1Forkhead box K1. (706 aa)
PABPN1LPoly(A) binding protein nuclear 1 like, cytoplasmic. (269 aa)
N4BP1NEDD4 binding protein 1. (904 aa)
TAF9TATA-box binding protein associated factor 9. (264 aa)
APOC3Apolipoprotein C3. (99 aa)
TRAF3IP2TRAF3 interacting protein 2. (596 aa)
CLEC16AC-type lectin domain containing 16A. (1050 aa)
ZFP36ZFP36 ring finger protein. (325 aa)
A0A4W2CEA8Uncharacterized protein. (102 aa)
MEIOCMeiosis specific with coiled-coil domain. (960 aa)
NOCTNocturnin. (530 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (562 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (806 aa)
NOP53NOP53 ribosome biogenesis factor. (534 aa)
A0A4W2CJ16Uncharacterized protein. (252 aa)
AXIN2Axin 2. (836 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)
LRPPRCLeucine rich pentatricopeptide repeat containing. (1394 aa)
TRDMT1tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (466 aa)
SLC11A1Solute carrier family 11 member 1. (601 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
ACACBAcetyl-CoA carboxylase beta. (2455 aa)
PHF23PHD finger protein 23. (402 aa)
QSOX1Sulfhydryl oxidase. (791 aa)
APOBEC1Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (236 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
DDRGK1DDRGK domain containing 1. (322 aa)
HTR2B5-hydroxytryptamine receptor 2B. (538 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (702 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
LOC113877294Myotubularin phosphatase domain-containing protein. (543 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
NBASNeuroblastoma amplified sequence. (2371 aa)
PDCL3Phosducin like 3. (240 aa)
PTPN3Protein tyrosine phosphatase non-receptor type 3. (1056 aa)
SGTASmall glutamine rich tetratricopeptide repeat containing alpha. (363 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (347 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1077 aa)
RUBCNRubicon autophagy regulator. (1011 aa)
CSDE1Cold shock domain containing E1. (844 aa)
FEZ2Fasciculation and elongation protein zeta 2. (376 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (333 aa)
PLIN5Perilipin; Belongs to the perilipin family. (456 aa)
TENT2Terminal nucleotidyltransferase 2. (576 aa)
IGF2BP2Insulin like growth factor 2 mRNA binding protein 2. (605 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1601 aa)
A0A4W2D9S8Uncharacterized protein. (346 aa)
KDM4AUncharacterized protein. (1066 aa)
PINK1PTEN induced kinase 1. (588 aa)
DHX36DEAH-box helicase 36. (1010 aa)
LEPRLeptin receptor. (1165 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (292 aa)
HNRNPA0Heterogeneous nuclear ribonucleoprotein A0. (314 aa)
NRDE2NRDE-2, necessary for RNA interference, domain containing. (1155 aa)
DND1DND microRNA-mediated repression inhibitor 1. (355 aa)
MTMR8Myotubularin related protein 8. (448 aa)
A0A4W2DJQ9USP domain-containing protein; Belongs to the peptidase C19 family. (2551 aa)
HMOX1Heme oxygenase 1. (302 aa)
SECISBP2SECIS binding protein 2. (844 aa)
UBXN1UBX domain protein 1. (297 aa)
GIPC2GIPC PDZ domain containing family member 2. (316 aa)
PHAXPhosphorylated adaptor for RNA export. (394 aa)
NPC1NPC intracellular cholesterol transporter 1. (1291 aa)
PARNPoly(A)-specific ribonuclease. (662 aa)
RBM10RNA binding motif protein 10. (995 aa)
RYBPRING1 and YY1 binding protein. (228 aa)
CCAR2Cell cycle and apoptosis regulator 2. (892 aa)
PKP3Plakophilin 3. (808 aa)
SORL1Sortilin related receptor 1. (2211 aa)
A1CFAPOBEC1 complementation factor. (595 aa)
ANGEL2Angel homolog 2. (544 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (843 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
TOB1Transducer of ERBB2, 1. (358 aa)
BOLLBoule homolog, RNA binding protein. (295 aa)
BAG5BCL2 associated athanogene 5. (447 aa)
SIRT2Sirtuin 2. (457 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
DHX34DExH-box helicase 34. (1146 aa)
KLHL22Kelch like family member 22. (634 aa)
CPTPCeramide-1-phosphate transfer protein. (214 aa)
DFFBDNA fragmentation factor subunit beta. (341 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
A0A4W2EAH7Uncharacterized protein. (77 aa)
PMLPromyelocytic leukemia. (871 aa)
A0A4W2EAX2NTR domain-containing protein. (232 aa)
BECN1Beclin 1. (471 aa)
VIPVasoactive intestinal peptide. (170 aa)
A0A4W2EFF5Uncharacterized protein. (258 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (985 aa)
TARDBPTAR DNA binding protein. (414 aa)
A0A4W2EHE4Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. (158 aa)
BMFBcl2 modifying factor. (184 aa)
TENT5ATerminal nucleotidyltransferase 5A. (453 aa)
PARK7Parkinsonism associated deglycase. (190 aa)
TENT5BTerminal nucleotidyltransferase 5B. (430 aa)
LOC113897311Uncharacterized protein. (313 aa)
TMEM39ATransmembrane protein 39A. (503 aa)
PBKPDZ binding kinase. (324 aa)
HIPK2Homeodomain interacting protein kinase 2. (1205 aa)
GIPC3GIPC PDZ domain containing family member 3. (318 aa)
A0A4W2EQZ6Uncharacterized protein. (832 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
TBC1D14TBC1 domain family member 14. (847 aa)
STYXSerine/threonine/tyrosine interacting protein. (223 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (537 aa)
UBQLN4Ubiquilin 4. (734 aa)
ETFBKMTElectron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
LARP1La ribonucleoprotein domain family member 1. (1145 aa)
DAZLRRM domain-containing protein. (305 aa)
YBX1Y-box binding protein 1. (324 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (400 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (14%) [HD]