STRINGSTRING
PSEN1 PSEN1 STK4 STK4 MEN1 MEN1 TCF7L2 TCF7L2 MMP9 MMP9 GCG GCG DACT1 DACT1 WNT3A WNT3A PLCL2 PLCL2 FLOT1 FLOT1 STK3 STK3 LRP1 LRP1 EPB41 EPB41 NVL NVL ABL1 ABL1 MAPRE1 MAPRE1 PRKN PRKN BDNF BDNF LRRK2 LRRK2 DERL1 DERL1 APOE APOE CDK5 CDK5 ARHGEF7 ARHGEF7 KRIT1 KRIT1 NMD3 NMD3 MFNG MFNG PLCL1 PLCL1 A0A4W2DJQ9 A0A4W2DJQ9 USP33 USP33 SPPL3 SPPL3 APP APP SPTA1 SPTA1 NPHP3 NPHP3 MARK3 MARK3 LFNG LFNG VTN VTN ADD2 ADD2 BAMBI BAMBI CTHRC1 CTHRC1 CLDN5 CLDN5 BMP4 BMP4 A0A4W2EHE4 A0A4W2EHE4 SPAG8 SPAG8 TRIB3 TRIB3 MAPRE3 MAPRE3 BLK BLK DTX3L DTX3L HIPK2 HIPK2 PKD1 PKD1 A0A4W2BQ76 A0A4W2BQ76 PLXND1 PLXND1 A0A4W2BXB8 A0A4W2BXB8 EP300 EP300 CSF3 CSF3 RFNG RFNG AKTIP AKTIP AMFR AMFR HIP1R HIP1R RIPK2 RIPK2 TERT TERT TRIM21 TRIM21 CAV1 CAV1 SPON1 SPON1 IDE IDE EPHB6 EPHB6 TMEM173 TMEM173 EPB41L5 EPB41L5 PIN1 PIN1 WNT5A WNT5A HFE HFE RALB RALB RAPGEF2 RAPGEF2 BMP2 BMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
STK4Serine/threonine kinase 4. (487 aa)
MEN1Menin 1. (610 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
MMP9Matrix metallopeptidase 9. (712 aa)
GCGGlucagon. (180 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (837 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
PLCL2Phosphoinositide phospholipase C. (1118 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
STK3Serine/threonine kinase 3. (491 aa)
LRP1LDL receptor related protein 1. (4544 aa)
EPB41Erythrocyte membrane protein band 4.1. (956 aa)
NVLNuclear VCP like. (855 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
MAPRE1Microtubule associated protein RP/EB family member 1. (295 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (258 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
APOEApolipoprotein E. (349 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
KRIT1Uncharacterized protein. (736 aa)
NMD360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (538 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (320 aa)
PLCL1Phosphoinositide phospholipase C. (1103 aa)
A0A4W2DJQ9USP domain-containing protein; Belongs to the peptidase C19 family. (2551 aa)
USP33Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (912 aa)
SPPL3Signal peptide peptidase like 3. (390 aa)
APPAmyloid beta precursor protein. (770 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2419 aa)
NPHP3TPR_REGION domain-containing protein. (1331 aa)
MARK3Non-specific serine/threonine protein kinase. (820 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (380 aa)
VTNSMB domain-containing protein. (476 aa)
ADD2Adducin 2. (724 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
A0A4W2EHE4Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. (158 aa)
SPAG8Sperm associated antigen 8. (484 aa)
TRIB3Tribbles pseudokinase 3. (403 aa)
MAPRE3Microtubule associated protein RP/EB family member 3. (281 aa)
BLKTyrosine-protein kinase. (524 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (739 aa)
HIPK2Homeodomain interacting protein kinase 2. (1205 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
A0A4W2BQ76USP domain-containing protein; Belongs to the peptidase C19 family. (713 aa)
PLXND1Plexin D1. (1930 aa)
A0A4W2BXB8Uncharacterized protein. (414 aa)
EP300E1A binding protein p300. (2411 aa)
CSF3Colony stimulating factor 3. (215 aa)
RFNGBeta-1,3-N-acetylglucosaminyltransferase. (336 aa)
AKTIPAKT interacting protein. (293 aa)
AMFRAutocrine motility factor receptor. (758 aa)
HIP1RHuntingtin interacting protein 1 related. (1066 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1125 aa)
TRIM21Tripartite motif containing 21. (511 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (211 aa)
SPON1Spondin 1. (807 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
EPHB6EPH receptor B6. (1007 aa)
TMEM173Transmembrane protein 173. (484 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (726 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (400 aa)
RALBRAS like proto-oncogene B. (206 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1689 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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