STRINGSTRING
SAR1A SAR1A A0A4W2CQ41 A0A4W2CQ41 UBAC2 UBAC2 MAVS MAVS GAS6 GAS6 EPM2A EPM2A GLI3 GLI3 SFN SFN CDH1 CDH1 OAZ2 OAZ2 LEP LEP GSK3B GSK3B HCLS1 HCLS1 LRRK2 LRRK2 CTDSPL2 CTDSPL2 TOMM7 TOMM7 RAPGEF3 RAPGEF3 APOD APOD OAZ1 OAZ1 TMEM30B TMEM30B PDZK1 PDZK1 PDCD10 PDCD10 KCNB1 KCNB1 DMTN DMTN PARL PARL OS9 OS9 CDK5 CDK5 INSIG1 INSIG1 ZC3H12A ZC3H12A ECT2 ECT2 SLC35D3 SLC35D3 TM9SF4 TM9SF4 A0A4W2DED4 A0A4W2DED4 PINK1 PINK1 DMAP1 DMAP1 INPP5K INPP5K SIRT6 SIRT6 UHMK1 UHMK1 SIAH3 SIAH3 TCAF1 TCAF1 A0A4W2DP37 A0A4W2DP37 SLC51B SLC51B PRKCD PRKCD RAB23 RAB23 SORL1 SORL1 ERBB2 ERBB2 TPR TPR RBM22 RBM22 A0A4W2E2B7 A0A4W2E2B7 GCC2 GCC2 GSK3A GSK3A A0A4W2E5D6 A0A4W2E5D6 UBE2J1 UBE2J1 NF1 NF1 CEP131 CEP131 SEC16B SEC16B ANP32B ANP32B A0A4W2EAH7 A0A4W2EAH7 ITGB1BP1 ITGB1BP1 ICE1 ICE1 ERLEC1 ERLEC1 SREBF1 SREBF1 TARDBP TARDBP ARHGAP44 ARHGAP44 BMP4 BMP4 IFNG IFNG IPO5 IPO5 UBR5 UBR5 SIRT7 SIRT7 ERGIC3 ERGIC3 FYN FYN CHP1 CHP1 PRR5L PRR5L PARK7 PARK7 FERMT1 FERMT1 EDEM2 EDEM2 PSEN1 PSEN1 SH3TC1 SH3TC1 PPM1A PPM1A AKAP5 AKAP5 SHH SHH C2CD5 C2CD5 HDAC3 HDAC3 SH3TC2 SH3TC2 EFCAB7 EFCAB7 UBE2G2 UBE2G2 FBXW9 FBXW9 A0A4W2F3Y4 A0A4W2F3Y4 BAG4 BAG4 PLK3 PLK3 SAR1B SAR1B B3GAT3 B3GAT3 DERL2 DERL2 LOC113897645 LOC113897645 PCM1 PCM1 PIK3R2 PIK3R2 TCF7L2 TCF7L2 GRASP GRASP MFF MFF PRKACA PRKACA PTPN1 PTPN1 TOMM7-2 TOMM7-2 SMO SMO BBC3 BBC3 PTPN11 PTPN11 TRIM28 TRIM28 PRKD1 PRKD1 FBXW7 FBXW7 OAZ3 OAZ3 HRAS HRAS A0A4W2HBP3 A0A4W2HBP3 ATP5IF1 ATP5IF1 PRKAA1 PRKAA1 XPO1 XPO1 TMEM30A TMEM30A PTPN22 PTPN22 C11orf65 C11orf65 CIB1 CIB1 HSPA1L HSPA1L CD81 CD81 PTPN14 PTPN14 ADIPOQ ADIPOQ ZPR1 ZPR1 DNAJC27 DNAJC27 EDEM1 EDEM1 JUP JUP XPO4 XPO4 YWHAE YWHAE CAMK1 CAMK1 UFM1 UFM1 CHP2 CHP2 SVIP SVIP A0A4W2BV94 A0A4W2BV94 HYAL2 HYAL2 RANGAP1 RANGAP1 MIEF2 MIEF2 A0A4W2C276 A0A4W2C276 BAG3 BAG3 MYO1C MYO1C LCP1 LCP1 NDEL1 NDEL1 CEMIP CEMIP PIK3R1 PIK3R1 ZFAND1 ZFAND1 RIPOR1 RIPOR1 YOD1 YOD1 AKT2 AKT2 TGFB1 TGFB1 MIEF1 MIEF1 PKIG PKIG DERL3 DERL3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
A0A4W2CQ41Uncharacterized protein. (620 aa)
UBAC2UBA domain containing 2. (365 aa)
MAVSMitochondrial antiviral signaling protein. (615 aa)
GAS6Growth arrest specific 6. (671 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
GLI3GLI family zinc finger 3. (1587 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
OAZ2Ornithine decarboxylase antizyme 2. (177 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (485 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
CTDSPL2CTD small phosphatase like 2. (466 aa)
TOMM7Uncharacterized protein. (59 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
APODApolipoprotein D. (217 aa)
OAZ1Ornithine decarboxylase antizyme 1. (225 aa)
TMEM30BCell cycle control protein; Belongs to the CDC50/LEM3 family. (353 aa)
PDZK1PDZ domain containing 1. (732 aa)
PDCD10Programmed cell death 10. (212 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
DMTNDematin actin binding protein. (467 aa)
PARLRhomboid domain-containing protein. (403 aa)
OS9OS9 endoplasmic reticulum lectin. (667 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (299 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (583 aa)
ECT2Epithelial cell transforming 2. (944 aa)
SLC35D3Solute carrier family 35 member D3. (423 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
A0A4W2DED4Uncharacterized protein. (107 aa)
PINK1PTEN induced kinase 1. (588 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (513 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (449 aa)
SIRT6Sirtuin 6. (391 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
SIAH3E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (272 aa)
TCAF1TRPM8 channel associated factor 1. (921 aa)
A0A4W2DP37Uncharacterized protein. (114 aa)
SLC51BSolute carrier family 51 beta subunit. (130 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
SORL1Sortilin related receptor 1. (2211 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1710 aa)
TPRTranslocated promoter region, nuclear basket protein. (2444 aa)
RBM22RNA binding motif protein 22. (420 aa)
A0A4W2E2B7Uncharacterized protein. (192 aa)
GCC2GRIP and coiled-coil domain containing 2. (1824 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
A0A4W2E5D6Uncharacterized protein. (144 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
NF1Neurofibromin 1. (3024 aa)
CEP131Centrosomal protein 131. (1154 aa)
SEC16BProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (1054 aa)
ANP32BAcidic nuclear phosphoprotein 32 family member B. (269 aa)
A0A4W2EAH7Uncharacterized protein. (77 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
ICE1Interactor of little elongation complex ELL subunit 1. (2172 aa)
ERLEC1Endoplasmic reticulum lectin 1. (483 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1146 aa)
TARDBPTAR DNA binding protein. (414 aa)
ARHGAP44Rho GTPase activating protein 44. (804 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IPO5Importin 5. (1097 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa)
SIRT7Sirtuin 7. (420 aa)
ERGIC3ERGIC and golgi 3. (394 aa)
FYNTyrosine-protein kinase. (537 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
PRR5LProline rich 5 like. (644 aa)
PARK7Parkinsonism associated deglycase. (190 aa)
FERMT1Fermitin family member 1. (711 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
SH3TC1SH3 domain and tetratricopeptide repeats 1. (1455 aa)
PPM1APPM-type phosphatase domain-containing protein. (454 aa)
AKAP5A-kinase anchoring protein 5. (428 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
C2CD5C2 calcium dependent domain containing 5. (1137 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
SH3TC2SH3 domain and tetratricopeptide repeats 2. (1360 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
UBE2G2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (380 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
A0A4W2F3Y4Uncharacterized protein. (92 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (335 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (242 aa)
LOC113897645Thioredoxin; Belongs to the thioredoxin family. (105 aa)
PCM1Pericentriolar material 1. (2220 aa)
PIK3R2Uncharacterized protein. (724 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
GRASPGeneral receptor for phosphoinositides 1 associated scaffold protein. (394 aa)
MFFMitochondrial fission factor. (409 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (429 aa)
TOMM7-2Uncharacterized protein. (55 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
BBC3Uncharacterized protein. (193 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
TRIM28Tripartite motif containing 28. (838 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
FBXW7F-box and WD repeat domain containing 7. (706 aa)
OAZ3Ornithine decarboxylase antizyme 3. (240 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
A0A4W2HBP3CARD_2 domain-containing protein. (65 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (109 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
XPO1Exportin 1. (1071 aa)
TMEM30ACell cycle control protein; Belongs to the CDC50/LEM3 family. (400 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (808 aa)
C11orf65Chromosome 11 open reading frame 65. (312 aa)
CIB1Calcium and integrin binding 1. (191 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
CD81Tetraspanin. (236 aa)
PTPN14Protein tyrosine phosphatase non-receptor type 14. (1190 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (328 aa)
ZPR1ZPR1 zinc finger. (459 aa)
DNAJC27DnaJ heat shock protein family (Hsp40) member C27. (273 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (658 aa)
JUPJunction plakoglobin. (745 aa)
XPO4Exportin 4. (1152 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (268 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (369 aa)
UFM1Uncharacterized protein. (196 aa)
CHP2Calcineurin like EF-hand protein 2. (258 aa)
SVIPUncharacterized protein. (77 aa)
A0A4W2BV94Uncharacterized protein. (136 aa)
HYAL2Hyaluronidase. (473 aa)
RANGAP1Ran GTPase activating protein 1. (585 aa)
MIEF2Mitochondrial elongation factor 2. (454 aa)
A0A4W2C276Uncharacterized protein. (275 aa)
BAG3BCL2 associated athanogene 3. (585 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1098 aa)
LCP1Lymphocyte cytosolic protein 1. (643 aa)
NDEL1NudE neurodevelopment protein 1 like 1. (377 aa)
CEMIPCell migration inducing hyaluronidase 1. (1416 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ZFAND1Zinc finger AN1-type containing 1. (268 aa)
RIPOR1RHO family interacting cell polarization regulator 1. (1330 aa)
YOD1YOD1 deubiquitinase. (303 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
MIEF1Mitochondrial elongation factor 1. (463 aa)
PKIGcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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