STRINGSTRING
STK11 STK11 RHNO1 RHNO1 RUVBL2 RUVBL2 TP53 TP53 DDB2 DDB2 AQP1 AQP1 TP53INP1 TP53INP1 ZBTB1 ZBTB1 OPN5 OPN5 MMP9 MMP9 MFAP4 MFAP4 ERCC4 ERCC4 TMEM161A TMEM161A EIF2S1 EIF2S1 CUL4B CUL4B COPS9 COPS9 PBK PBK BMF BMF EP300 EP300 CDKN1A CDKN1A OPN1SW OPN1SW POLD3 POLD3 USP47 USP47 AURKB AURKB MC1R MC1R HYAL3 HYAL3 MAPK13 MAPK13 KDM1A KDM1A SIRT1 SIRT1 POLH POLH CHEK1 CHEK1 A0A4W2DQR1 A0A4W2DQR1 PRKCD PRKCD C9orf116 C9orf116 NFATC4 NFATC4 CREBBP CREBBP ATR ATR ACTR5 ACTR5 DHX36 DHX36 MME MME POLK POLK PCNA PCNA NOC2L NOC2L CASP9 CASP9 PTPRK PTPRK PARP1 PARP1 PPID PPID INO80 INO80 NEDD4 NEDD4 SDE2 SDE2 XPC XPC DDB1 DDB1 IMPACT IMPACT HYAL2 HYAL2 HYAL1 HYAL1 BAK1 BAK1 XPA XPA RHBDD1 RHBDD1 POLD1 POLD1 SMPD1 SMPD1 MMP3 MMP3 ERCC1 ERCC1 CDC25A CDC25A MMP2 MMP2 PIK3R1 PIK3R1 N4BP1 N4BP1 YY1 YY1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (240 aa)
ZBTB1Zinc finger and BTB domain containing 1. (713 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (355 aa)
MMP9Matrix metallopeptidase 9. (712 aa)
MFAP4Microfibril associated protein 4. (255 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
TMEM161ATransmembrane protein 161A. (478 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
CUL4BCullin 4B; Belongs to the cullin family. (734 aa)
COPS9Uncharacterized protein. (57 aa)
PBKPDZ binding kinase. (324 aa)
BMFBcl2 modifying factor. (184 aa)
EP300E1A binding protein p300. (2411 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
OPN1SWOpsin 1, short wave sensitive. (349 aa)
POLD3Uncharacterized protein. (425 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1374 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (406 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (317 aa)
HYAL3Hyaluronidase. (389 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (877 aa)
SIRT1Sirtuin 1. (734 aa)
POLHDNA polymerase eta. (711 aa)
CHEK1Checkpoint kinase 1. (677 aa)
A0A4W2DQR1LIM zinc-binding domain-containing protein. (244 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
C9orf116Chromosome 9 open reading frame 116. (136 aa)
NFATC4Nuclear factor of activated T cells 4. (979 aa)
CREBBPCREB binding protein. (2435 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (615 aa)
DHX36DEAH-box helicase 36. (1010 aa)
MMEMembrane metalloendopeptidase. (775 aa)
POLKDNA polymerase kappa. (911 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (754 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1471 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1016 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
INO80INO80 complex ATPase subunit. (1584 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1321 aa)
SDE2SDE2 telomere maintenance homolog. (453 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (932 aa)
DDB1Damage specific DNA binding protein 1. (1506 aa)
IMPACTImpact RWD domain protein. (458 aa)
HYAL2Hyaluronidase. (473 aa)
HYAL1Hyaluronidase. (435 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
RHBDD1Rhomboid domain containing 1. (322 aa)
POLD1DNA polymerase. (1106 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (351 aa)
CDC25ACell division cycle 25A. (525 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
N4BP1NEDD4 binding protein 1. (904 aa)
YY1YY1 transcription factor. (415 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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