STRINGSTRING
APPL1 APPL1 POU4F2 POU4F2 A0A4W2IQB7 A0A4W2IQB7 INSR INSR LRRC26 LRRC26 EDN1 EDN1 ADIPOQ ADIPOQ FGF19 FGF19 ATP1B2 ATP1B2 IGF1 IGF1 A0A4W2I3U5 A0A4W2I3U5 A0A4W2I2L4 A0A4W2I2L4 STAC3 STAC3 PRKCI PRKCI A0A4W2HEF8 A0A4W2HEF8 NFE2L2 NFE2L2 ARC ARC CA2 CA2 EPHB2 EPHB2 PTPN11 PTPN11 KCNQ1 KCNQ1 VMP1 VMP1 CXCL9 CXCL9 APLNR APLNR CD19 CD19 NPPA NPPA ITGB1 ITGB1 SNCA SNCA DRD1 DRD1 PIRT PIRT C1QTNF12 C1QTNF12 AKT1 AKT1 KCNIP2 KCNIP2 TREM2 TREM2 EDNRA EDNRA PLCG2 PLCG2 ATP1B3 ATP1B3 RELN RELN LRRC52 LRRC52 A0A4W2F0Q7 A0A4W2F0Q7 CASQ1 CASQ1 TRPC1 TRPC1 C2CD5 C2CD5 STIM2 STIM2 GRM6 GRM6 CXCL11 CXCL11 ERFE ERFE CXCL10 CXCL10 A0A4W2ET73 A0A4W2ET73 PSEN1 PSEN1 BRAF BRAF CHP1 CHP1 TRDN TRDN A0A4W2EIV4 A0A4W2EIV4 R3HDM2 R3HDM2 COA8 COA8 F2 F2 ANO6 ANO6 WNK3 WNK3 HAP1 HAP1 MS4A1 MS4A1 CACNG4 CACNG4 ATPSCKMT ATPSCKMT RAMP3 RAMP3 A0A4W2E9C2 A0A4W2E9C2 AZIN1 AZIN1 CLIP3 CLIP3 LRRC38 LRRC38 A0A4W2E674 A0A4W2E674 RHOQ RHOQ P2RX7 P2RX7 A0A4W2DZW8 A0A4W2DZW8 GPER1 GPER1 GALR2 GALR2 ACTN2 ACTN2 ACSL5 ACSL5 CXCR3 CXCR3 DRD4 DRD4 AKAP9 AKAP9 A0A4W2DR90 A0A4W2DR90 A0A4W2DQY6 A0A4W2DQY6 WNK2 WNK2 TCAF1 TCAF1 R3HDM1 R3HDM1 ADRB2 ADRB2 PDPK1 PDPK1 SLC17A8 SLC17A8 COX17 COX17 A0A4W2DFD9 A0A4W2DFD9 PKD2 PKD2 CAPN10 CAPN10 CREBL2 CREBL2 F2R F2R NDUFA4 NDUFA4 NR4A3 NR4A3 A0A4W2D9C0 A0A4W2D9C0 KCNH2 KCNH2 AMIGO1 AMIGO1 PDZK1 PDZK1 OSBPL8 OSBPL8 HSPA2 HSPA2 A0A4W2D4F2 A0A4W2D4F2 CALM1 CALM1 HTT HTT CACNB3 CACNB3 C3 C3 SLC9A1 SLC9A1 IRS2 IRS2 ATP1B1 ATP1B1 OCLN OCLN CAPN3 CAPN3 ABL1 ABL1 AZIN2 AZIN2 PTH PTH SRI SRI SLC1A2 SLC1A2 RNF207 RNF207 FGF21 FGF21 NPSR1 NPSR1 LRRC55 LRRC55 CAV1 CAV1 CFTR CFTR AKT2 AKT2 RYR2 RYR2 STIM1 STIM1 TERT TERT WNK4 WNK4 P2RX4 P2RX4 SLC26A6 SLC26A6 AKAP6 AKAP6 RNASEL RNASEL STAC STAC MEF2A MEF2A PIK3R1 PIK3R1 CEMIP CEMIP WNK1 WNK1 A0A4W2C5I5 A0A4W2C5I5 CRACR2A CRACR2A RAB44 RAB44 TRPC6 TRPC6 STAC2 STAC2 TRPC3 TRPC3 AMIGO3 AMIGO3 BAK1 BAK1 ATP2A1 ATP2A1 THY1 THY1 CHP2 CHP2 A0A4W2BND6 A0A4W2BND6 STIMATE STIMATE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
POU4F2POU domain protein. (408 aa)
A0A4W2IQB7Uncharacterized protein. (106 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
LRRC26Leucine rich repeat containing 26. (328 aa)
EDN1Endothelin 1. (202 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (328 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
IGF1Insulin like growth factor 1. (188 aa)
A0A4W2I3U5Uncharacterized protein. (296 aa)
A0A4W2I2L4Fibrinogen C-terminal domain-containing protein. (301 aa)
STAC3SH3 and cysteine rich domain 3. (362 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
A0A4W2HEF8Uncharacterized protein. (88 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (642 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
EPHB2EPH receptor B2. (986 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (670 aa)
VMP1Vacuole membrane protein 1. (406 aa)
CXCL9C-X-C motif chemokine. (125 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CD19CD19 molecule. (568 aa)
NPPANatriuretic peptide A. (188 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (137 aa)
C1QTNF12C1q and TNF related 12. (299 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (244 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
RELNReelin. (3460 aa)
LRRC52Leucine rich repeat containing 52. (320 aa)
A0A4W2F0Q7Fibrinogen C-terminal domain-containing protein. (323 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (395 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
C2CD5C2 calcium dependent domain containing 5. (1137 aa)
STIM2Stromal interaction molecule 2. (927 aa)
GRM6Glutamate metabotropic receptor 6. (871 aa)
CXCL11C-X-C motif chemokine. (100 aa)
ERFEErythroferrone. (340 aa)
CXCL10C-X-C motif chemokine. (102 aa)
A0A4W2ET73AIG1-type G domain-containing protein. (310 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
TRDNTriadin. (727 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
R3HDM2Uncharacterized protein. (1023 aa)
COA8Cytochrome c oxidase assembly factor 8. (257 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (631 aa)
ANO6Anoctamin. (931 aa)
WNK3WNK lysine deficient protein kinase 3. (1789 aa)
HAP1Huntingtin associated protein 1. (574 aa)
MS4A1Membrane spanning 4-domains A1. (303 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (321 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (221 aa)
RAMP3Receptor activity modifying protein 3. (150 aa)
A0A4W2E9C2Uncharacterized protein. (461 aa)
AZIN1Antizyme inhibitor 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (448 aa)
CLIP3CAP-Gly domain containing linker protein 3. (547 aa)
LRRC38Leucine rich repeat containing 38. (299 aa)
A0A4W2E674Uncharacterized protein. (264 aa)
RHOQRas homolog family member Q. (209 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
A0A4W2DZW8Fibrinogen C-terminal domain-containing protein. (312 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
GALR2Galanin receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ACTN2Actinin alpha 2. (894 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (683 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (409 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (372 aa)
AKAP9A-kinase anchoring protein 9. (3907 aa)
A0A4W2DR90Uncharacterized protein. (70 aa)
A0A4W2DQY6C-X-C motif chemokine. (138 aa)
WNK2WNK lysine deficient protein kinase 2. (2229 aa)
TCAF1TRPM8 channel associated factor 1. (921 aa)
R3HDM1R3H domain containing 1. (1118 aa)
ADRB2Adrenoceptor beta 2. (418 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (747 aa)
SLC17A8Solute carrier family 17 member 8. (588 aa)
COX17Cytochrome c oxidase copper chaperone COX17. (63 aa)
A0A4W2DFD9Uncharacterized protein. (305 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (1071 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (645 aa)
CREBL2cAMP responsive element binding protein like 2. (120 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NDUFA4Uncharacterized protein. (82 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (651 aa)
A0A4W2D9C0AIG1-type G domain-containing protein. (321 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1161 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
PDZK1PDZ domain containing 1. (732 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (910 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
A0A4W2D4F2AIG1-type G domain-containing protein. (297 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
HTTHuntingtin. (3119 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (496 aa)
C3Complement C3. (1695 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (818 aa)
IRS2Insulin receptor substrate 2. (1325 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (822 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
AZIN2Antizyme inhibitor 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (502 aa)
PTHParathyroid hormone. (147 aa)
SRISorcin. (198 aa)
SLC1A2Amino acid transporter. (595 aa)
RNF207Ring finger protein 207. (633 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (390 aa)
LRRC55Leucine rich repeat containing 55. (311 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (211 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
RYR2Ryanodine receptor 2. (4967 aa)
STIM1Stromal interaction molecule 1. (789 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1125 aa)
WNK4WNK lysine deficient protein kinase 4. (1239 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (394 aa)
SLC26A6Solute carrier family 26 member 6. (763 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
RNASELRibonuclease L. (723 aa)
STACSH3 and cysteine rich domain. (403 aa)
MEF2AMyocyte enhancer factor 2A. (503 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CEMIPCell migration inducing hyaluronidase 1. (1416 aa)
WNK1WNK lysine deficient protein kinase 1. (2386 aa)
A0A4W2C5I5Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
CRACR2ACalcium release activated channel regulator 2A. (723 aa)
RAB44RAB44, member RAS oncogene family. (984 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
STAC2SH3 and cysteine rich domain 2. (438 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (873 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (519 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1010 aa)
THY1Thy-1 cell surface antigen. (161 aa)
CHP2Calcineurin like EF-hand protein 2. (258 aa)
A0A4W2BND6IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
STIMATEUncharacterized protein. (296 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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