STRINGSTRING
IFT57 IFT57 SOX18 SOX18 AHI1 AHI1 HAND2 HAND2 MEF2C MEF2C ARL13B ARL13B IFT52 IFT52 WNT3A WNT3A LBX1 LBX1 GJA1 GJA1 HIF1A HIF1A TEAD2 TEAD2 SMO SMO CLUAP1 CLUAP1 CTNNB1 CTNNB1 TBX6 TBX6 NODAL NODAL A0A4W2BYK4 A0A4W2BYK4 YAP1 YAP1 SUFU SUFU FOXH1 FOXH1 ASB2 ASB2 EDN1 EDN1 TBX3 TBX3 MESP1 MESP1 MEGF8 MEGF8 RYR2 RYR2 SRF SRF IHH IHH CITED2 CITED2 APLNR APLNR FGF8 FGF8 TBX20 TBX20 EDNRA EDNRA WNT5A WNT5A ECE1 ECE1 NKX2-6 NKX2-6 NOTCH2 NOTCH2 SHH SHH SMAD3 SMAD3 PSEN1 PSEN1 POPDC2 POPDC2 C2CD3 C2CD3 A0A4W2EEW9 A0A4W2EEW9 SOX17 SOX17 ENG ENG TGFBR2 TGFBR2 CCDC40 CCDC40 CCDC103 CCDC103 APELA APELA NPHP3 NPHP3 NOTCH1 NOTCH1 MIB1 MIB1 MED1 MED1 HAND1 HAND1 HES1 HES1 CDC42 CDC42 PKD2 PKD2 CCDC39 CCDC39 DLL1 DLL1 PLXNA4 PLXNA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFT57Intraflagellar transport 57. (429 aa)
SOX18SRY-box transcription factor 18. (389 aa)
AHI1Abelson helper integration site 1. (1163 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ARL13BADP ribosylation factor like GTPase 13B. (429 aa)
IFT52Intraflagellar transport 52. (440 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LBX1Ladybird homeobox 1. (282 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (383 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
CLUAP1Clusterin associated protein 1. (561 aa)
CTNNB1Catenin beta 1. (774 aa)
TBX6T-box transcription factor 6. (437 aa)
NODALNodal growth differentiation factor. (346 aa)
A0A4W2BYK4Dynein assembly factor 1, axonemal. (927 aa)
YAP1Yes associated protein 1. (507 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
FOXH1Forkhead box H1. (359 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (633 aa)
EDN1Endothelin 1. (202 aa)
TBX3T-box transcription factor 3. (748 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
RYR2Ryanodine receptor 2. (4967 aa)
SRFSerum response factor. (509 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (412 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (368 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TBX20T-box transcription factor 20. (449 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ECE1Endothelin converting enzyme 1. (871 aa)
NKX2-6NK2 homeobox 6. (300 aa)
NOTCH2Notch receptor 2. (2471 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
POPDC2Popeye domain containing 2. (364 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2339 aa)
A0A4W2EEW9Uncharacterized protein. (1936 aa)
SOX17SRY-box transcription factor 17. (410 aa)
ENGEndoglin. (649 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
CCDC40Coiled-coil domain containing 40. (1125 aa)
CCDC103Coiled-coil domain containing 103. (235 aa)
APELAUncharacterized protein. (54 aa)
NPHP3TPR_REGION domain-containing protein. (1331 aa)
NOTCH1Notch receptor 1. (2533 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
HAND1Heart and neural crest derivatives expressed 1. (394 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
CDC42Cell division cycle 42. (191 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (1071 aa)
CCDC39Coiled-coil domain containing 39. (941 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (722 aa)
PLXNA4Plexin A4. (1893 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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