STRINGSTRING
SIRT6 SIRT6 ZBTB7A ZBTB7A ZGRF1 ZGRF1 PRPF19 PRPF19 ARPC2 ARPC2 VCP VCP SMC6 SMC6 HUS1 HUS1 SIRT7 SIRT7 ARPC3 ARPC3 CGAS CGAS PNKP PNKP A0A4W2EMP6 A0A4W2EMP6 ESCO2 ESCO2 REC114 REC114 RPA3 RPA3 RIF1 RIF1 LMNA LMNA XRCC4 XRCC4 A0A4W2F3C1 A0A4W2F3C1 A0A4W2F400 A0A4W2F400 NABP2 NABP2 APLF APLF INTS3 INTS3 INIP INIP TIMELESS TIMELESS ARPC5 ARPC5 HELB HELB RNF8 RNF8 TP53 TP53 POLL POLL RAD18 RAD18 SMARCA5 SMARCA5 PARP3 PARP3 A0A4W2BP37 A0A4W2BP37 TP53BP1 TP53BP1 DDB1 DDB1 PAXX PAXX RFWD3 RFWD3 PHF1 PHF1 MRE11 MRE11 SLF2 SLF2 ARPC1A ARPC1A TONSL TONSL ARPC4 ARPC4 WRAP53 WRAP53 NBN NBN WDR70 WDR70 A0A4W2DY12 A0A4W2DY12 SMCHD1 SMCHD1 POLH POLH RBBP8 RBBP8 WAS WAS UFL1 UFL1 CNTD1 CNTD1 RNF169 RNF169 SMARCAL1 SMARCAL1 A0A4W2CSP1 A0A4W2CSP1 RPA2 RPA2 SMC5 SMC5 SAMHD1 SAMHD1 A0A4W2CWS1 A0A4W2CWS1 A0A4W2CX26 A0A4W2CX26 PARP1 PARP1 RAD51 RAD51 SHLD2 SHLD2 SLF1 SLF1 A0A4W2D2X3 A0A4W2D2X3 RNF168 RNF168 ATF2 ATF2 A0A4W2DA03 A0A4W2DA03 SMARCAD1 SMARCAD1 ACTR3 ACTR3 A0A4W2DHA5 A0A4W2DHA5 A0A4W2DJN4 A0A4W2DJN4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRT6Sirtuin 6. (391 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (567 aa)
ZGRF1Zinc finger GRF-type containing 1. (2171 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (816 aa)
SMC6Structural maintenance of chromosomes 6. (1098 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
SIRT7Sirtuin 7. (420 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (190 aa)
CGASCyclic GMP-AMP synthase. (513 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (550 aa)
A0A4W2EMP6Uncharacterized protein. (232 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (610 aa)
REC114REC114 meiotic recombination protein. (255 aa)
RPA3Replication protein A3. (121 aa)
RIF1Replication timing regulatory factor 1. (2465 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
XRCC4X-ray repair cross complementing 4. (333 aa)
A0A4W2F3C1RPA_C domain-containing protein. (250 aa)
A0A4W2F400Uncharacterized protein. (410 aa)
NABP2Nucleic acid binding protein 2. (211 aa)
APLFAprataxin and PNKP like factor. (509 aa)
INTS3Integrator complex subunit 3. (1040 aa)
INIPINTS3 and NABP interacting protein. (104 aa)
TIMELESSTimeless circadian regulator. (1213 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
HELBDNA helicase B. (1136 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (501 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1051 aa)
PARP3Poly [ADP-ribose] polymerase. (515 aa)
A0A4W2BP37Uncharacterized protein. (74 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
DDB1Damage specific DNA binding protein 1. (1506 aa)
PAXXPAXX non-homologous end joining factor. (224 aa)
RFWD3Ring finger and WD repeat domain 3. (790 aa)
PHF1PHD finger protein 1. (603 aa)
MRE11MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1167 aa)
ARPC1AWD_REPEATS_REGION domain-containing protein. (430 aa)
TONSLTonsoku like, DNA repair protein. (1375 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (809 aa)
WDR70WD repeat domain 70. (652 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1997 aa)
POLHDNA polymerase eta. (711 aa)
RBBP8RB binding protein 8, endonuclease. (859 aa)
WASWASP actin nucleation promoting factor. (559 aa)
UFL1UFM1 specific ligase 1. (792 aa)
CNTD1Cyclin N-terminal domain containing 1. (328 aa)
RNF169Ring finger protein 169. (708 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (937 aa)
A0A4W2CSP1Uncharacterized protein. (319 aa)
RPA2RPA_C domain-containing protein. (270 aa)
SMC5SMC_N domain-containing protein. (1197 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (608 aa)
A0A4W2CWS1RPA_C domain-containing protein. (253 aa)
A0A4W2CX26Uncharacterized protein. (284 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1016 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
SHLD2Shieldin complex subunit 2. (962 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1175 aa)
A0A4W2D2X3Zinc-hook domain-containing protein. (1440 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
ATF2Activating transcription factor 2. (447 aa)
A0A4W2DA03Uncharacterized protein; Belongs to the actin family. (416 aa)
SMARCAD1Uncharacterized protein. (1029 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (418 aa)
A0A4W2DHA5Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (159 aa)
A0A4W2DJN4Uncharacterized protein; Belongs to the actin family. (356 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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