STRINGSTRING
CCDC186 CCDC186 KLF7 KLF7 STK11 STK11 INSR INSR CNR1 CNR1 IGF1R IGF1R ADIPOQ ADIPOQ CRY1 CRY1 CYP7A1 CYP7A1 RBM4 RBM4 ADIPOR1 ADIPOR1 CARTPT CARTPT NCOA5 NCOA5 BHLHA15 BHLHA15 FOXK2 FOXK2 PDK4 PDK4 LRRC8A LRRC8A PRKAA1 PRKAA1 HIF1A HIF1A LOC113893369 LOC113893369 CAV3 CAV3 POMC POMC PTPN11 PTPN11 DHPS DHPS FOXA3 FOXA3 FAM3B FAM3B GCG GCG PRKACA PRKACA NR1H4 NR1H4 GCK GCK LOC113899433 LOC113899433 TCF7L2 TCF7L2 HNF4A HNF4A FBN1 FBN1 DUPD1 DUPD1 PIK3R2 PIK3R2 ZBTB20 ZBTB20 STXBP3 STXBP3 AKT1 AKT1 SIN3A SIN3A SELENOT SELENOT IL6 IL6 G6PC2 G6PC2 CSMD2 CSMD2 SLC39A14 SLC39A14 A0A4W2EUX9 A0A4W2EUX9 HK3 HK3 NEUROD1 NEUROD1 TRA2B TRA2B PCK2 PCK2 ALOX5 ALOX5 STXBP5L STXBP5L SLC12A6 SLC12A6 PARK7 PARK7 CRY2 CRY2 A0A4W2EJS8 A0A4W2EJS8 FOXA1 FOXA1 SLC8B1 SLC8B1 ADGRF5 ADGRF5 A0A4W2ECP6 A0A4W2ECP6 PCK1 PCK1 A0A4W2EBW4 A0A4W2EBW4 STAT3 STAT3 RFX6 RFX6 RBP4 RBP4 CCN4 CCN4 PAX6 PAX6 ADCY8 ADCY8 A0A4W2E314 A0A4W2E314 ADIPOR2 ADIPOR2 PDK2 PDK2 ASPSCR1 ASPSCR1 GPER1 GPER1 ADRA2A ADRA2A SIRT1 SIRT1 NOX4 NOX4 RPH3AL RPH3AL RMI1 RMI1 VGF VGF PIK3CA PIK3CA WFS1 WFS1 APPL2 APPL2 SOX4 SOX4 INPP5K INPP5K A0A4W2DH90 A0A4W2DH90 CRTC2 CRTC2 SUCNR1 SUCNR1 LEPR LEPR BACE2 BACE2 PRKAA2 PRKAA2 MBD5 MBD5 PYGL PYGL KCNB1 KCNB1 PTCH1 PTCH1 CYB5R4 CYB5R4 PFKM PFKM RAB11B RAB11B LRRC8D LRRC8D LEP LEP G6PC G6PC GAS6 GAS6 PTPRN PTPRN GCGR GCGR PLSCR3 PLSCR3 HNF1A HNF1A TRPV4 TRPV4 FABP5 FABP5 HK2 HK2 A0A4W2CIJ2 A0A4W2CIJ2 AGER AGER FFAR1 FFAR1 RAB11FIP2 RAB11FIP2 FOXO3 FOXO3 GPI GPI A0A4W2CD20 A0A4W2CD20 ERN1 ERN1 SLC37A4 SLC37A4 HECTD4 HECTD4 BAD BAD PIK3R1 PIK3R1 SLC2A4 SLC2A4 FOXK1 FOXK1 A0A4W2C5I5 A0A4W2C5I5 CSMD1 CSMD1 HK1 HK1 A0A4W2BZH9 A0A4W2BZH9 TFAP2B TFAP2B SESN3 SESN3 SIDT2 SIDT2 NR1D1 NR1D1 A0A4W2BWV5 A0A4W2BWV5 DBH DBH MCU MCU KAT5 KAT5 PTPN2 PTPN2 RAF1 RAF1 CSRP3 CSRP3 MLXIPL MLXIPL SSTR5 SSTR5 PRCP PRCP A0A4W2BND6 A0A4W2BND6 A0A4W2BLA5 A0A4W2BLA5 PDX1 PDX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCDC186Coiled-coil domain containing 186. (899 aa)
KLF7Kruppel like factor 7. (302 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (328 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (500 aa)
RBM4RNA binding motif protein 4. (362 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
CARTPTCART prepropeptide. (116 aa)
NCOA5Nuclear receptor coactivator 5. (584 aa)
BHLHA15Basic helix-loop-helix family member a15. (187 aa)
FOXK2Forkhead box K2. (658 aa)
PDK4Protein-serine/threonine kinase. (407 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
LOC113893369CCDC144C domain-containing protein. (309 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
POMCProopiomelanocortin. (265 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
DHPSUncharacterized protein. (369 aa)
FOXA3Forkhead box A3. (350 aa)
FAM3BFamily with sequence similarity 3 member B. (266 aa)
GCGGlucagon. (180 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
GCKPhosphotransferase. (466 aa)
LOC113899433Olfactory receptor. (313 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
FBN1Fibrillin 1. (2871 aa)
DUPD1Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (219 aa)
PIK3R2Uncharacterized protein. (724 aa)
ZBTB20Zinc finger and BTB domain containing 20. (751 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (576 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (194 aa)
IL6Interleukin 6. (208 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
CSMD2CUB and Sushi multiple domains 2. (3364 aa)
SLC39A14Solute carrier family 39 member 14. (531 aa)
A0A4W2EUX9Uncharacterized protein. (178 aa)
HK3Hexokinase 3. (924 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
TRA2BTransformer 2 beta homolog. (288 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (820 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
STXBP5LSyntaxin binding protein 5 like. (1233 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
PARK7Parkinsonism associated deglycase. (190 aa)
CRY2Cryptochrome circadian regulator 2. (661 aa)
A0A4W2EJS8ANK_REP_REGION domain-containing protein. (1397 aa)
FOXA1Forkhead box A1. (468 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (648 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1418 aa)
A0A4W2ECP6Uncharacterized protein. (141 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (694 aa)
A0A4W2EBW4CCDC144C domain-containing protein. (326 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
RFX6Regulatory factor X6. (927 aa)
RBP4Retinol binding protein 4; Belongs to the calycin superfamily. Lipocalin family. (314 aa)
CCN4Cellular communication network factor 4. (368 aa)
PAX6Paired box 6. (455 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
A0A4W2E314G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (365 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
ASPSCR1ASPSCR1 tether for SLC2A4, UBX domain containing. (552 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
ADRA2AAdrenoceptor alpha 2A. (468 aa)
SIRT1Sirtuin 1. (734 aa)
NOX4NADPH oxidase 4. (578 aa)
RPH3ALRabphilin 3A like (without C2 domains). (374 aa)
RMI1RecQ mediated genome instability 1. (624 aa)
VGFVGF nerve growth factor inducible. (656 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
WFS1Wolframin ER transmembrane glycoprotein. (888 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (659 aa)
SOX4SRY-box transcription factor 4. (501 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (449 aa)
A0A4W2DH90Uncharacterized protein. (209 aa)
CRTC2Uncharacterized protein. (693 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (316 aa)
LEPRLeptin receptor. (1165 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (514 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
MBD5Methyl-CpG binding domain protein 5. (1731 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (859 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
PTCH1Patched 1. (1453 aa)
CYB5R4Cytochrome b5 reductase 4. (617 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (850 aa)
RAB11BUncharacterized protein. (267 aa)
LRRC8DLeucine rich repeat containing 8 VRAC subunit D. (858 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
GAS6Growth arrest specific 6. (671 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (479 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (303 aa)
HNF1AHNF1 homeobox A. (633 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (803 aa)
FABP5Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
HK2Hexokinase 2. (917 aa)
A0A4W2CIJ2Uncharacterized protein. (164 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
RAB11FIP2RAB11 family interacting protein 2. (511 aa)
FOXO3Forkhead box O3. (617 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (565 aa)
A0A4W2CD20ANK_REP_REGION domain-containing protein. (274 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (974 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
HECTD4HECT domain E3 ubiquitin protein ligase 4. (4415 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
FOXK1Forkhead box K1. (706 aa)
A0A4W2C5I5Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
CSMD1CUB and Sushi multiple domains 1. (3561 aa)
HK1Hexokinase 1. (920 aa)
A0A4W2BZH9Uncharacterized protein. (727 aa)
TFAP2BTranscription factor AP-2 beta. (488 aa)
SESN3Sestrin 3. (492 aa)
SIDT2SID1 transmembrane family member 2. (852 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
A0A4W2BWV5ANK_REP_REGION domain-containing protein. (353 aa)
DBHDopamine beta-hydroxylase. (621 aa)
MCUMitochondrial calcium uniporter. (355 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CSRP3Cysteine and glycine rich protein 3. (200 aa)
MLXIPLMLX interacting protein like. (856 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (368 aa)
PRCPProlylcarboxypeptidase. (499 aa)
A0A4W2BND6IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
A0A4W2BLA5CCDC144C domain-containing protein. (336 aa)
PDX1Pancreatic and duodenal homeobox 1. (285 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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