STRINGSTRING
PML PML LATS2 LATS2 SOX8 SOX8 CDON CDON GSX1 GSX1 FEZF2 FEZF2 IRF4 IRF4 CTNNB1 CTNNB1 TGFB1I1 TGFB1I1 GATA2 GATA2 HNF1B HNF1B TBX6 TBX6 GATA6 GATA6 ZNF521 ZNF521 SMAD2 SMAD2 MYOD1 MYOD1 SOX6 SOX6 ONECUT2 ONECUT2 NODAL NODAL BCL2 BCL2 RARA RARA RUNX2 RUNX2 A0A4W2BXP4 A0A4W2BXP4 TBX21 TBX21 SUFU SUFU NKX6-2 NKX6-2 CASP3 CASP3 ISL2 ISL2 WNT5B WNT5B EHMT2 EHMT2 MITF MITF JAG2 JAG2 TEAD4 TEAD4 TBX3 TBX3 WNT7A WNT7A NANOG NANOG APC APC GSC GSC MESP1 MESP1 TBX5 TBX5 HEY2 HEY2 TBX10 TBX10 WNT3 WNT3 WNT11 WNT11 NR2E1 NR2E1 PAF1 PAF1 POU3F2 POU3F2 NTF4 NTF4 TBX18 TBX18 EPAS1 EPAS1 IL7 IL7 HES5 HES5 PRDM14 PRDM14 TGFBR1 TGFBR1 HOXA11 HOXA11 EXT1 EXT1 ONECUT1 ONECUT1 WNT6 WNT6 IHH IHH HOXA13 HOXA13 MTOR MTOR GLI3 GLI3 LATS1 LATS1 MGA MGA SOX18 SOX18 DLL4 DLL4 KIAA1549 KIAA1549 WNT10B WNT10B GATA3 GATA3 ID2 ID2 GATA4 GATA4 RTF1 RTF1 DLL1 DLL1 POU4F1 POU4F1 PTF1A PTF1A DHH DHH SOX13 SOX13 BARHL2 BARHL2 PTCH1 PTCH1 PRADC1 PRADC1 MYT1L MYT1L DLX1 DLX1 VWA5B2 VWA5B2 STAT6 STAT6 KDR KDR GBX1 GBX1 WNT4 WNT4 SIX1 SIX1 WNT9A WNT9A SOX5 SOX5 DLX2 DLX2 GSX2 GSX2 CDC42 CDC42 GDF7 GDF7 GAP43 GAP43 PTCH2 PTCH2 ASCL1 ASCL1 IL6R IL6R TBXT TBXT TAL1 TAL1 HOXC10 HOXC10 A0A4W2DK14 A0A4W2DK14 HES1 HES1 TENM4 TENM4 TBX4 TBX4 EOMES EOMES SMAD4 SMAD4 FOXN1 FOXN1 WNT7B WNT7B SMAD1 SMAD1 TEAD3 TEAD3 TBX2 TBX2 SFRP2 SFRP2 PITX1 PITX1 SFRP1 SFRP1 NOTCH1 NOTCH1 ARHGEF2 ARHGEF2 PROX1 PROX1 FOXN4 FOXN4 EPOP EPOP GCM1 GCM1 PAX6 PAX6 KDM6B KDM6B BCL11B BCL11B PDPN PDPN EYA1 EYA1 NKX2-1 NKX2-1 STAT3 STAT3 PRRX1 PRRX1 SOX17 SOX17 GATA5 GATA5 WNT8B WNT8B LEO1 LEO1 CYP26B1 CYP26B1 FEV FEV BMP4 BMP4 HOXA2 HOXA2 FOXA1 FOXA1 FOXG1 FOXG1 BRAF BRAF PSEN1 PSEN1 NEUROD1 NEUROD1 SHH SHH MNX1 MNX1 HOXD10 HOXD10 APC2 APC2 EBF2 EBF2 VWA5B1 VWA5B1 NEUROG1 NEUROG1 IL6 IL6 OLIG2 OLIG2 SLAMF6 SLAMF6 LY9 LY9 DOCK7 DOCK7 TBX19 TBX19 WNT5A WNT5A LHX3 LHX3 EDNRA EDNRA ETV2 ETV2 WNT2 WNT2 ISL1 ISL1 RHOA RHOA SMAD5 SMAD5 TBX20 TBX20 FGF8 FGF8 TM2D3 TM2D3 BMP2 BMP2 CTR9 CTR9 TCF7L2 TCF7L2 CTSV CTSV NEUROD4 NEUROD4 TBX1 TBX1 DMRT3 DMRT3 SOSTDC1 SOSTDC1 ITGB1 ITGB1 MYL2 MYL2 TBX15 TBX15 TBR1 TBR1 WNT16 WNT16 WNT10A WNT10A TOX TOX NR2F2 NR2F2 SIX2 SIX2 SMO SMO VWA5A VWA5A SOX12 SOX12 BATF BATF ERBB4 ERBB4 OLIG3 OLIG3 PRDM1 PRDM1 LBX1 LBX1 FGF10 FGF10 WNT3A WNT3A DMRTA2 DMRTA2 WNT8A WNT8A RAG2 RAG2 WNT2B WNT2B ATOH1 ATOH1 TP53 TP53 WNT1 WNT1 TLX3 TLX3 WNT9B WNT9B DBX1 DBX1 EDN1 EDN1 MEF2C MEF2C OLIG1 OLIG1 SOX9 SOX9 SPRY2 SPRY2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PMLPromyelocytic leukemia. (871 aa)
LATS2Large tumor suppressor kinase 2. (1015 aa)
SOX8SRY-box transcription factor 8. (534 aa)
CDONCell adhesion associated, oncogene regulated. (1247 aa)
GSX1GS homeobox 1. (335 aa)
FEZF2FEZ family zinc finger 2. (459 aa)
IRF4Interferon regulatory factor 4. (451 aa)
CTNNB1Catenin beta 1. (774 aa)
TGFB1I1Transforming growth factor beta 1 induced transcript 1; Belongs to the paxillin family. (456 aa)
GATA2GATA binding protein 2. (596 aa)
HNF1BHNF1 homeobox B. (558 aa)
TBX6T-box transcription factor 6. (437 aa)
GATA6GATA binding protein 6. (662 aa)
ZNF521Zinc finger protein 521. (1311 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (318 aa)
SOX6SRY-box transcription factor 6. (855 aa)
ONECUT2One cut domain family member. (557 aa)
NODALNodal growth differentiation factor. (346 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
RARARetinoic acid receptor alpha. (477 aa)
RUNX2RUNX family transcription factor 2. (527 aa)
A0A4W2BXP4Homeobox domain-containing protein. (263 aa)
TBX21T-box transcription factor 21. (532 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
NKX6-2NK6 homeobox 2. (278 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
ISL2ISL LIM homeobox 2. (359 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1389 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1239 aa)
TEAD4TEA domain transcription factor 4. (652 aa)
TBX3T-box transcription factor 3. (748 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
NANOGHomeobox domain-containing protein. (285 aa)
APCAPC regulator of WNT signaling pathway. (2912 aa)
GSCGoosecoid homeobox. (266 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
TBX5T-box transcription factor 5. (561 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
TBX10T-box transcription factor 10. (381 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (532 aa)
POU3F2POU class 3 homeobox 2. (414 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (306 aa)
TBX18T-box transcription factor 18. (612 aa)
EPAS1Endothelial PAS domain protein 1. (928 aa)
IL7Interleukin 7. (185 aa)
HES5Hes family bHLH transcription factor 5. (227 aa)
PRDM14PR/SET domain 14. (571 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
HOXA11Homeobox A11. (316 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
ONECUT1One cut domain family member. (712 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (412 aa)
HOXA13Homeobox A13. (388 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
GLI3GLI family zinc finger 3. (1587 aa)
LATS1Large tumor suppressor kinase 1. (1123 aa)
MGAMAX dimerization protein MGA. (3065 aa)
SOX18SRY-box transcription factor 18. (389 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
KIAA1549KIAA1549. (1941 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (433 aa)
GATA3GATA binding protein 3. (467 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
GATA4GATA binding protein 4. (660 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (714 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (722 aa)
POU4F1POU domain protein. (421 aa)
PTF1APancreas associated transcription factor 1a. (326 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (401 aa)
SOX13SRY-box transcription factor 13. (623 aa)
BARHL2BarH like homeobox 2. (383 aa)
PTCH1Patched 1. (1453 aa)
PRADC1Protease associated domain containing 1. (188 aa)
MYT1LMyelin transcription factor 1 like. (1205 aa)
DLX1Distal-less homeobox 1. (255 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1247 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GBX1Gastrulation brain homeobox 1. (365 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (585 aa)
SIX1SIX homeobox 1. (284 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SOX5SRY-box transcription factor 5. (763 aa)
DLX2Distal-less homeobox 2. (331 aa)
GSX2GS homeobox 2. (305 aa)
CDC42Cell division cycle 42. (191 aa)
GDF7Growth differentiation factor 7. (411 aa)
GAP43Growth associated protein 43. (260 aa)
PTCH2Patched 2. (1207 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
IL6RInterleukin 6 receptor. (464 aa)
TBXTT-box transcription factor T. (435 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
HOXC10Homeobox C10. (373 aa)
A0A4W2DK14Uncharacterized protein. (350 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
TENM4Teneurin transmembrane protein 4. (2949 aa)
TBX4T-box transcription factor 4. (550 aa)
EOMESEomesodermin. (701 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
FOXN1Forkhead box N1. (644 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (472 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
TBX2T-box transcription factor 2. (714 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
PITX1Homeobox protein. (314 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
NOTCH1Notch receptor 1. (2533 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1223 aa)
PROX1Prospero homeobox 1. (738 aa)
FOXN4Forkhead box N4. (546 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
GCM1Glial cells missing transcription factor 1. (433 aa)
PAX6Paired box 6. (455 aa)
KDM6BLysine demethylase 6B. (1665 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (903 aa)
PDPNUncharacterized protein. (169 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (700 aa)
NKX2-1NK2 homeobox 1. (408 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRRX1Paired related homeobox 1. (245 aa)
SOX17SRY-box transcription factor 17. (410 aa)
GATA5GATA binding protein 5. (403 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (668 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
FEVFEV transcription factor, ETS family member. (239 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
HOXA2Homeobox A2. (372 aa)
FOXA1Forkhead box A1. (468 aa)
FOXG1Forkhead box G1. (491 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
MNX1Motor neuron and pancreas homeobox 1. (403 aa)
HOXD10Homeobox D10. (410 aa)
APC2APC regulator of WNT signaling pathway 2. (2264 aa)
EBF2EBF transcription factor 2. (575 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1208 aa)
NEUROG1Neurogenin 1. (247 aa)
IL6Interleukin 6. (208 aa)
OLIG2Oligodendrocyte transcription factor 2. (327 aa)
SLAMF6SLAM family member 6. (352 aa)
LY9Lymphocyte antigen 9. (670 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2147 aa)
TBX19T-box transcription factor 19. (446 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LHX3LIM homeobox 3. (403 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ETV2ETS variant 2. (331 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ISL1ISL LIM homeobox 1. (349 aa)
RHOARas homolog family member A. (193 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TBX20T-box transcription factor 20. (449 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TM2D3TM2 domain containing 3. (290 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (334 aa)
NEUROD4Neurogenic differentiation factor. (330 aa)
TBX1T-box transcription factor 1. (486 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (568 aa)
SOSTDC1Sclerostin domain containing 1. (228 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MYL2Myosin light chain 2. (166 aa)
TBX15T-box transcription factor 15. (602 aa)
TBR1T-box brain transcription factor 1. (682 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
TOXThymocyte selection associated high mobility group box. (527 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
SIX2SIX homeobox 2. (296 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
VWA5AVon Willebrand factor A domain containing 5A. (785 aa)
SOX12Transcription factor SOX. (314 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
PRDM1PR/SET domain 1. (842 aa)
LBX1Ladybird homeobox 1. (282 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
DMRTA2DMRT like family A2. (535 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RAG2Recombination activating 2. (527 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
ATOH1Atonal bHLH transcription factor 1. (352 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TLX3T cell leukemia homeobox 3. (338 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
DBX1Developing brain homeobox 1. (345 aa)
EDN1Endothelin 1. (202 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
OLIG1Oligodendrocyte transcription factor 1. (266 aa)
SOX9SRY-box transcription factor 9. (524 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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