22 items (Bos indicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	A0A4W2DQY6	C-X-C motif chemokine. (138 aa)
	SOX8	SRY-box transcription factor 8. (534 aa)
	TBX3	T-box transcription factor 3. (748 aa)
	TGFB1	Transforming growth factor beta 1. (443 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (722 aa)
	NMRK2	Nicotinamide riboside kinase 2. (195 aa)
	CMTM5	CKLF like MARVEL transmembrane domain containing 5. (156 aa)
	ID3	Inhibitor of DNA binding 3, HLH protein. (119 aa)
	TMEM182	Transmembrane protein 182. (274 aa)
	SRA1	Steroid receptor RNA activator 1. (237 aa)
	NOTCH1	Notch receptor 1. (2533 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	CXCL10	C-X-C motif chemokine. (102 aa)
	SOX9	SRY-box transcription factor 9. (524 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (834 aa)
	SOSTDC1	Sclerostin domain containing 1. (228 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	CXCL14	C-X-C motif chemokine ligand 14. (99 aa)
	MSTN	Myostatin. (375 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2DQY6	CXCL14	A0A4W2DQY6	A0A4W2FK09	C-X-C motif chemokine.	C-X-C motif chemokine ligand 14.	0.850
A0A4W2DQY6	IL18	A0A4W2DQY6	A0A4W2DXR7	C-X-C motif chemokine.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.569
A0A4W2DQY6	TNF	A0A4W2DQY6	A0A4W2EFB5	C-X-C motif chemokine.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.640
BMP4	SOX9	A0A4W2EH28	A0A4W2IPK8	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.566
BMP4	TBX3	A0A4W2EH28	A0A4W2C837	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.447
CXCL10	CXCL14	A0A4W2EV59	A0A4W2FK09	C-X-C motif chemokine.	C-X-C motif chemokine ligand 14.	0.850
CXCL10	IL18	A0A4W2EV59	A0A4W2DXR7	C-X-C motif chemokine.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.569
CXCL10	TNF	A0A4W2EV59	A0A4W2EFB5	C-X-C motif chemokine.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.640
CXCL14	A0A4W2DQY6	A0A4W2FK09	A0A4W2DQY6	C-X-C motif chemokine ligand 14.	C-X-C motif chemokine.	0.850
CXCL14	CXCL10	A0A4W2FK09	A0A4W2EV59	C-X-C motif chemokine ligand 14.	C-X-C motif chemokine.	0.850
DLL1	NOTCH1	A0A4W2CZB1	A0A4W2DXI1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.986
IL18	A0A4W2DQY6	A0A4W2DXR7	A0A4W2DQY6	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	C-X-C motif chemokine.	0.569
IL18	CXCL10	A0A4W2DXR7	A0A4W2EV59	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	C-X-C motif chemokine.	0.569
IL18	TGFB1	A0A4W2DXR7	A0A4W2CIK8	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Transforming growth factor beta 1.	0.463
IL18	TNF	A0A4W2DXR7	A0A4W2EFB5	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.731
NOTCH1	DLL1	A0A4W2DXI1	A0A4W2CZB1	Notch receptor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.986
NOTCH1	SOX9	A0A4W2DXI1	A0A4W2IPK8	Notch receptor 1.	SRY-box transcription factor 9.	0.444
NOTCH1	TGFB1	A0A4W2DXI1	A0A4W2CIK8	Notch receptor 1.	Transforming growth factor beta 1.	0.434
NOTCH1	TNF	A0A4W2DXI1	A0A4W2EFB5	Notch receptor 1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.537
SOX9	BMP4	A0A4W2IPK8	A0A4W2EH28	SRY-box transcription factor 9.	Bone morphogenetic protein 4.	0.566

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